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90641por Martin, Sebastian, Maus, Stephan, Stemler, Tobias, Rosar, Florian, Khreish, Fadi, Holland, Jason P., Ezziddin, Samer, Bartholomä, Mark D.“…Three c(RGDfK) peptide residues were conjugated to the NOTI-TVA 6 building block by standard peptide chemistry providing the trimeric bioconjugate NOTI-TVA-c(RGDfK)(3) 9. …”
Publicado 2020
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90642por Nachawi, Noura, Paredes, Stephania, Seibert, Stephen, McShane, Adam, Pantalone, Kevin M“…Total Ca measurements were performed with the Ca Gen.2 assay on a cobas c702 chemistry analyzer (Roche Diagnostics). Results greater than the analytical measurement range (0.8 – 20.1 mg/dL) were diluted with saline and confirmed (22.6 mg/dL). …”
Publicado 2021
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90643“…Use of serum FSH to identify perimenopausal women with pituitary hCG. Clinical Chemistry. 2008. 54:4. 652-6.…”
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90644por Bai, Xue, Dai, Jie, Li, Caili, Cui, Chuanliang, Mao, Lili, Wei, Xiaoting, Sheng, Xinan, Chi, Zhihong, Yan, Xieqiao, Tang, Bixia, Lian, Bin, Wang, Xuan, Zhou, Li, Li, Siming, Kong, Yan, Qi, Zhonghui, Xu, Huayan, Duan, Rong, Guo, Jun, Si, Lu“…Clinicodemographical characteristics, baseline and early-on-treatment (median 0.6 months after anti-PD-1 monotherapy initiation) routine laboratory variables, including complete blood count and general chemistry, and best response/survival data were extracted and analyzed in both univariate and multivariate logistic and Cox proportional hazard models. …”
Publicado 2021
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90645por Hernández-Hermoso, José A., Nescolarde, Lexa, Roca, Emma, Revuelta-López, Elena, Ara, Jordi, Bayes-Genis, Antoni“…Serum C reactive protein (CRP), creatin kinase (CK), and lactate dehydrogenase (LDH) were determined using an AU-5800 chemistry analyser. Serum levels of hyaluronan (HA), cartilage oligomeric matrix protein (COMP), aggrecan chondroitin sulphate 846 (CS846), glycoprotein YKL-40, human procollagen II N-terminal propeptide (PIINP), human type IIA collagen N-propeptide (PIIANP), and collagen type II cleavage (C2C) were measured by sandwich enzyme-linked immune-sorbent assay (ELISA). …”
Publicado 2021
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90646por Gupta, Sneha V., Fanget, Marie C., MacLauchlin, Christopher, Clausen, Valerie A., Li, Jing, Cloutier, Daniel, Shen, Ling, Robbie, Gabriel J., Mogalian, Erik“…VIR-2218 was designed to silence HBV transcripts across all genotypes and uses Enhanced Stabilization Chemistry Plus (ESC+) technology. This study was designed to evaluate the single-dose pharmacokinetics of VIR-2218 in preclinical species and healthy volunteers. …”
Publicado 2021
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90647por ter Horst, Anneliek M., Santos-Medellín, Christian, Sorensen, Jackson W., Zinke, Laura A., Wilson, Rachel M., Johnston, Eric R., Trubl, Gareth, Pett-Ridge, Jennifer, Blazewicz, Steven J., Hanson, Paul J., Chanton, Jeffrey P., Schadt, Christopher W., Kostka, Joel E., Emerson, Joanne B.“…RESULTS: Within the SPRUCE experiment, viral community composition was significantly correlated with peat depth, water content, and carbon chemistry, including CH(4) and CO(2) concentrations, but not with temperature during the first 2 years of warming treatments. …”
Publicado 2021
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90648por Behrens, Chris, Fairman, Jeff, Agarwal, Paresh, Arulkumar, Shylaja, Barbanel, Sandrine, Bautista, Leslie, Berges, Aym, Burky, John, Davey, Peter, Grainger, Chris, Guo, Sherry, Iki, Sam, Iverson, Mark, Kapoor, Neeraj, Marcq, Olivier, Migone, Thi-Sau, Pill, Lucy, Sardar, Mohammed, Sauer, Paul, Wassil, James“…METHODS: The eCRM carrier protein was individually conjugated to each of 31 selected pneumococcal PSs using copper-free click chemistry to produce 31 Conjugate Drug Substances (DS), which were then mixed with aluminum phosphate to produce the VAX-XP Drug Product. 24 of the DS conjugates in VAX-XP were generated at manufacturing scale. …”
Publicado 2021
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90649por Damerow, Helen, Hübner, Ralph, Judmann, Benedikt, Schirrmacher, Ralf, Wängler, Björn, Fricker, Gert, Wängler, Carmen“…The chelators were identically functionalized with tetrazines, enabling a fully comparable, efficient, chemoselective and biorthogonal conjugation chemistry for the modification of any complementarily derivatized biomolecules of interest. …”
Publicado 2021
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90650por Malerba, P, Agabiti Rosei, C, Nardin, M, Gaggero, A, Chiarini, G, Rossini, C, Fama', F, Brami, V, Coschignano, M A, Muiesan, M L, Rizzoni, D, De Ciuceis, C“…Adaptive Optics, which allows a non-invasive evaluation of retinal arteriole structure, and blood chemistry exams were performed as part of follow up visits between 2 to 3 months after hospitalization. …”
Publicado 2021
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90651por Gruber, Franz S, Johnston, Zoe C, Norcross, Neil R, Georgiou, Irene, Wilson, Caroline, Read, Kevin D, Gilbert, Ian H, Swedlow, Jason R, Martins da Silva, Sarah, Barratt, Christopher L R“…In addition to furthering our understanding of human sperm function, for example identifying new avenues for discovery, we highlight potential compounds as promising start-point for a medicinal chemistry programme for potential enhancement of male fertility. …”
Publicado 2022
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90652por Greenwood, Sharlene A., Beckley-Hoelscher, Nicholas, Asgari, Elham, Ayis, Salma, Baker, Luke A., Banerjee, Debasish, Bhandari, Sunil, Bramham, Kate, Chilcot, Joseph, Burton, James, Kalra, Philip A., Lightfoot, Courtney J., McCafferty, Kieran, Mercer, Thomas H., Okonko, Darlington O., Oliveira, Benjamin, Reid, Chante, Smith, Alice C., Swift, Pauline A., Mangelis, Anastasios, Watson, Emma, Wheeler, David C., Wilkinson, Thomas J., Reid, Fiona, Macdougall, Iain C.“…Additional secondary outcomes include fatigue, physical function, muscle strength, muscle metabolism, quality of life, resting blood pressure, clinical chemistry, safety and harms associated with the iron therapy intervention and the exercise training intervention, and hospitalisations. …”
Publicado 2022
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90653“…Microextraction is a rapidly developing sample preparation technology in the field of analytical chemistry, which is seeing widespread application. …”
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90654por LI, Wei, JIANG, Zhenzhen, LI, Han, TU, Pengfei, SONG, Qingqing, YU, Juan, SONG, Yuelin“…Online PLE-UHPLC-IT-TOF-MS is not only a tool fit for the concept of green analytical chemistry, but also a reliable analytical pipeline for the direct characterisation of other complicated matrixes. …”
Publicado 2021
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90655“…Second, the consumption of the mobile phase is reduced, making the process environmentally friendly and facilitating green chemistry. This allows the addition of more expensive solvent additives, such as chiral additives or isotopic reagents, while maintaining a low analysis cost. …”
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90656“…Therefore, CE-MS has proved to be important in analytical chemistry, especially in proteomics and metabolomics. …”
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90657por Hoffmann, Kyra, Schilling, Jana Viola, Wandrey, Georg, Welters, Tim, Mahr, Stefan, Conrath, Uwe, Büchs, Jochen“…For industrial application we here report a high-throughput, online identification method for identifying priming-inducing chemistry. RESULTS: This study describes the development of a high-throughput screening system that enables identifying and analyzing the impact of defense priming-inducing compounds in microtiter plates. …”
Publicado 2023
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90658por Alderson, Lili, Wakeford, Hannah R., Alam, Munazza K., Batalha, Natasha E., Lothringer, Joshua D., Adams Redai, Jea, Barat, Saugata, Brande, Jonathan, Damiano, Mario, Daylan, Tansu, Espinoza, Néstor, Flagg, Laura, Goyal, Jayesh M., Grant, David, Hu, Renyu, Inglis, Julie, Lee, Elspeth K. H., Mikal-Evans, Thomas, Ramos-Rosado, Lakeisha, Roy, Pierre-Alexis, Wallack, Nicole L., Batalha, Natalie M., Bean, Jacob L., Benneke, Björn, Berta-Thompson, Zachory K., Carter, Aarynn L., Changeat, Quentin, Colón, Knicole D., Crossfield, Ian J. M., Désert, Jean-Michel, Foreman-Mackey, Daniel, Gibson, Neale P., Kreidberg, Laura, Line, Michael R., López-Morales, Mercedes, Molaverdikhani, Karan, Moran, Sarah E., Morello, Giuseppe, Moses, Julianne I., Mukherjee, Sagnick, Schlawin, Everett, Sing, David K., Stevenson, Kevin B., Taylor, Jake, Aggarwal, Keshav, Ahrer, Eva-Maria, Allen, Natalie H., Barstow, Joanna K., Bell, Taylor J., Blecic, Jasmina, Casewell, Sarah L., Chubb, Katy L., Crouzet, Nicolas, Cubillos, Patricio E., Decin, Leen, Feinstein, Adina D., Fortney, Joanthan J., Harrington, Joseph, Heng, Kevin, Iro, Nicolas, Kempton, Eliza M.-R., Kirk, James, Knutson, Heather A., Krick, Jessica, Leconte, Jérémy, Lendl, Monika, MacDonald, Ryan J., Mancini, Luigi, Mansfield, Megan, May, Erin M., Mayne, Nathan J., Miguel, Yamila, Nikolov, Nikolay K., Ohno, Kazumasa, Palle, Enric, Parmentier, Vivien, Petit dit de la Roche, Dominique J. M., Piaulet, Caroline, Powell, Diana, Rackham, Benjamin V., Redfield, Seth, Rogers, Laura K., Rustamkulov, Zafar, Tan, Xianyu, Tremblin, P., Tsai, Shang-Min, Turner, Jake D., de Val-Borro, Miguel, Venot, Olivia, Welbanks, Luis, Wheatley, Peter J., Zhang, Xi“…These results, including the detection of SO(2), underscore the importance of characterizing the chemistry in exoplanet atmospheres and showcase NIRSpec G395H as an excellent mode for time-series observations over this critical wavelength range(10).…”
Publicado 2023
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90659por Hauk, Johannes“…A longtime later, after the concepts of atoms and of particles such as electrons andalpha particles were established by scientific research in physics and chemistry,Rutherford’s scattering experiment discovering the atomic nucleus founded avital technique to analyse the composition of matter in sub-atomic dimensions.Research on the experimental side – mainly via scattering experiments – andon the theoretical side, extended the picture and the new discipline particlephysics was born. …”
Publicado 2012
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90660por Vidana Gamage, Hashni Epa, Shahoei, Sayyed Hamed, Albright, Samuel, Nguyen, Tiffany, Farmer, Rachel Elizabeth, Weisser, Erin, Bautista Rivas, Rafael Ovidio, Schane, Claire P, Wang, Yu, Nelczyk, Adam, Ma, Liqian, Tiwari, Srishti, Gupta, Anasuya Das, Bendre, Shruti, Apetoh, Lionel, Hergenrother, Paul, Nelson, Erik Russell“…Subsequent medicinal chemistry was used to develop a novel NR0B2 agonist with strong anti-metastatic properties when used as a single agent in a preclinical mouse model. …”
Publicado 2023
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