“…Consequently, there exists a need for a method to efficiently and accurately detect fusions in targeted PCR-based NGS chemistries. We describe SeekFusion, a highly accurate and computationally efficient pipeline enabling identification of gene fusions from PCR-based NGS chemistries. …”
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“…We find that among the major solid electrolyte chemistries (oxides, sulfides, nitrides, and halides), sulfide SEs are generally predicted to be the most stable against the S(8) cathode, while the other SE chemistries are predicted to be highly electrochemically unstable. …”
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“…The silicon surface can be functionalized to be compatible with traditional carboxyl immobilization chemistries, as well as with aldehyde-hydrazine bioconjugation chemistries. …”
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“…We present a young Hispanic female presented with cholestatic liver chemistries who has been taking Celecoxib for 3 weeks. …”
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“…Developing greener batteries with new chemistries is a formidable challenge, and a major focus for years to come. …”
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“…Our success in this regard hinged on the development of competitive chemistries anchoring or releasing the nanocrystals to or from the interface. …”
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“…How this active site performs such different chemistries is unknown. Here, we report the structures of CysG bound to precorrin-2, the initial substrate; sirohydrochlorin, the dehydrogenation product/chelation substrate; and a cobalt-sirohydrochlorin product. …”
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“…Here, a new catalyst class delivers unusual selectivity and is self‐switched between different polymerization cycles to construct specific sequences and desirable chain‐end chemistries. The best catalyst is a trinuclear dizinc(II)sodium(I) complex and it functions without additives or co‐catalysts. …”
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“…However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. …”
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“…Metal/organic-molecule interactions underpin many key chemistries but occur on sub-nm scales where nanoscale visualisation techniques tend to average over heterogeneous distributions. …”
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“…This study provides a general strategy for designing new BRMs that may enrich the cell chemistries of organic redox-flow batteries.…”
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“…Therefore, monitoring liver chemistries, especially AST is necessary for hospitalized patients with COVID-19.…”
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“…The key innovation is that the regeneration of lithium was successfully performed for all relevant cathode chemistries, including their mixture.…”
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“…While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. …”
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“…Membraneless compartments, such as complex coacervates, have been hypothesized as plausible prebiotic micro-compartments due to their ability to sequester RNA; however, their compatibility with essential RNA World chemistries is unclear. We show that such compartments can enhance key prebiotically-relevant RNA chemistries. …”
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“…The inclusion of appropriate functionalities into these materials by various chemistries has enhanced their repair mechanisms activated by crack formation. …”
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“…New mode-of-action chemistries are urgently sought to enhance vector management practices in countries where arthropod-borne diseases are endemic, especially where vector populations have acquired widespread resistance to insecticides. …”
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“…Efficient dose-dependent skipping of targeted exon 23 was achieved in myoblasts with MOE AOs of different lengths and backbone chemistries. Furthermore, we established that 25-mer MOE phosphorothioate (PS) AOs provided the greatest exon-skipping efficacy. …”
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“…By studying the changing compositions of a random copolymer of styrene and butadiene sheared at 10 °C in the presence of different additives we developed an approach to characterizing this growth/fracture competition, which is generalizable to other underlying chemistries. Our results demonstrate that constructive remodeling is achievable under practically relevant conditions, requires neither complex chemistries, elaborate macromolecular architectures or free monomers, and is amenable to detailed mechanistic interrogation and simulation. …”
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“…We are utilizing cutting edge siRNA chemistries to develop a therapeutic specifically targeting this oncohistone H3.3 K27M. …”
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