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  1. 91181
    “…The urinary concentrating ability of mice was studied in terms of daily urine output, urine osmolality, and urine and plasma chemistries. Changes in renal morphology were evaluated by hematoxylin and eosin staining. …”
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    UT-B-deficient mice develop renal dysfunction and structural damage
  2. 91182
    “…Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γ(c), We find that in the IL-15—IL-15Rα—IL-2Rβ—γ(c) quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γ(c) identically to the IL-2—IL-2Rα—IL-2Rβ—γ(c) complex, despite differing receptor-binding chemistries. IL-15Rα dramatically increases the affinity of IL-15 for IL-2Rβ, and this allostery is required for IL-15 trans-signaling versus IL-2 cis-signaling. …”
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    Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
  3. 91183
    “…Photoinitiated click chemistries are well suited for rapid polymerization of the core fluid by irradiation with ultraviolet light. …”
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    Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
  4. 91184
    “…The design of the present study included varying lengths of exenatide exposure (3, 6 weeks to 12 weeks) at multiple concentrations (3, 10, or 30 µg/kg) with multiple endpoints (histopathology evaluations, immunoassay for cytokines, immunostaining of the pancreas, serum chemistries and measurement of trypsin, amylase, and, lipase, and gene expression profiles). …”
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    Extended Exenatide Administration Enhances Lipid Metabolism and Exacerbates Pancreatic Injury in Mice on a High Fat, High Carbohydrate Diet
  5. 91185
    “…Exon 11 and/or 12 skipping for the normal PAH gene was validated in hepatoma cells for comparing two oligonucleotide chemistries, morpholinos and locked nucleic acids. Subsequently, Vivo-morpholinos (VMO) were tested in wild-type and in phenotypically normal Pah(enu2/+) heterozygous mice to target exon 11 and/or 12 of the murine Pah gene using different VMO dosing, mode of injection and treatment regimes. …”
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    A Sensitive Assay System To Test Antisense Oligonucleotides for Splice Suppression Therapy in the Mouse Liver
  6. 91186
    “…These results contribute to our fundamental understanding of pioneer colonization of conifer wood and provide insight into the diverse chemistries employed by fungi in carbon cycling processes.…”
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    Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood
  7. 91187
    por Karwautz, Clemens, Lueders, Tillmann
    Publicado 2014
    “…Variations were observed in bacterial communities between different wells of the same production system before maintenance, despite them having practically identical water chemistries. This may have reflected the distinct usage practices of the different wells, and also local aquifer heterogeneity. …”
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    Impact of Hydraulic Well Restoration on Native Bacterial Communities in Drinking Water Wells
  8. 91188
    “…Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space and the chemistries that must be considered for pathway reconstruction. …”
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    Experimental Strategies for Functional Annotation and Metabolism Discovery: Targeted Screening of Solute Binding Proteins and Unbiased Panning of Metabolomes
  9. 91189
    “…Initial work-up should typically include electrocardiography, chest X-ray, serum chemistries, complete blood count, and urinalysis. Initial management of hypertensive emergencies generally includes the use of intravenous or oral antihypertensive medications, as well as appropriate, typically outpatient, follow-up. …”
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    Evaluation and management of pediatric hypertensive crises: hypertensive urgency and hypertensive emergencies
  10. 91190
    “…Overall, these data indicate the divergence of several major Rossmann-fold enzyme classes, with different cofactors and catalytic chemistries, from a common pre-LUCA (last universal common ancestor) ancestor that possessed the β2-Asp/Glu motif.…”
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    An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors
  11. 91191
    por Hildyard, John CW, Wells, Dominic J
    Publicado 2016
    “…The discovery that dystrophin mRNA is subject to translational suppression by the microRNA miR31, and that miR31 is elevated in the muscle of DMD patients, raises the possibility that the same oligonucleotide chemistries employed for exon skipping could be directed toward relieving this translational block. …”
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    Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy
  12. 91192
    por Goodenough, John B, Zhou, Jianshi
    Publicado 2015
    “…Different structural chemistries resulting from the Pb(2+) lone-pair electrons in the PbMO(3) perovskites are reviewed. …”
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    Varied roles of Pb in transition-metal PbMO(3) perovskites (M = Ti, V, Cr, Mn, Fe, Ni, Ru)
  13. 91193
    “…Modified nucleotide chemistries that increase the half-life (T(1/2)) of transfected recombinant mRNA and the use of non-native 5′- and 3′-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy. …”
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    Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts
  14. 91194
    “…We believe these unsatisfactory results and varied performances are mainly due to the enrichment methods used, the diverse sequencing chemistries of the different NGS platforms, and other errors within the sequencing process. …”
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    The reliable assurance of detecting somatic mutations in cancer-related genes by next-generation sequencing: the results of external quality assessment in China
  15. 91195
    “…The results demonstrated that extraction chemistries do not have affect on amplification performance. …”
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    PowerPlex(®) Fusion 6C System: evaluation study for analysis of casework and database samples
  16. 91196
    por Ottesen, Eric W.
    Publicado 2017
    “…The success of Spinraza(™) underscores the potential of intronic sequences as promising therapeutic targets and sets the stage for further improvement of antisense drugs based on advanced oligonucleotide chemistries and delivery protocols.…”
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    ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy
  17. 91197
    “…Different backbone chemistries were found to have a strong impact on the ON efficiency. …”
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    CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression
  18. 91198
    “…Unfortunately, their therapeutic application, particularly that of the more potent chemistries (e.g., locked-nucleic-acid-containing gapmers), has been hampered by their frequent hepatoxicity, which could be driven by hybridization-mediated interactions. …”
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    Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs
  19. 91199
    “…This case highlights the importance of reviewing medications carefully when evaluating a patient with liver enzymes elevation, as stopping the offending drug can normalize the abnormalities in liver chemistries and can prevent subsequent expensive testing.…”
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    Allopurinol-Induced Granulomatous Hepatitis: A Case Report and Review of Literature
  20. 91200
    “…We take advantage of the innate contrasting surface chemistries of parylene-C and SiO(2) to enable selective bonding of polyethylene glycol SiO(2) surfaces, i.e. …”
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    Selective PEGylation of Parylene-C/SiO(2) Substrates for Improved Astrocyte Cell Patterning
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