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981“…An emerging field of microfluidics also known as the lab-on-a-chip (LOC) or micro total analysis system includes a wide range of diagnostic devices. …”
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982por Veltkamp, Henk-Willem, Akegawa Monteiro, Fernanda, Sanders, Remco, Wiegerink, Remco, Lötters, Joost“…This paper describes the development of a fabrication process and the proof-of-principle of a disposable DNA amplification chip with an integrated heater. Based on the analysis of the milling process, metal adhesion studies, and COMSOL MultiPhysics heat transfer simulations, the first batch of chips has been fabricated and successful multiple displacement amplification reactions are performed inside these chips. …”
Publicado 2020
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983por Wijesinghe, Udumbara, Dey, Akash Neel, Marshall, Andrew, Krenik, William, Duan, Can, Edwards, Hal, Lee, Mark“…Because the light spot is formed by a pinhole aperture integrated on the sensor chip, no external focusing optics are needed, reducing system complexity, size, and weight. …”
Publicado 2020
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984por Rattle, Simon, Hofmann, Oliver, Price, Christopher P., Kricka, Larry J., Wild, DavidEnlace del recurso
Publicado 2013
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985“…We recreated the biogenesis of Escherichia coli’s small ribosomal subunit by synthesizing and capturing all its ribosomal proteins and RNA on a chip. Surface confinement provided favorable conditions for autonomous stepwise assembly of new subunits, spatially segregated from original intact ribosomes. …”
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986por Nawroth, Janna C., Barrile, Riccardo, Conegliano, David, van Riet, Sander, Hiemstra, Pieter S., Villenave, Remi“…The merger of two novel technologies, Organs-on-Chips and human stem cell engineering, has the potential to deliver such urgently needed models. …”
Publicado 2019
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987por Cotter, J. P., McGilligan, J. P., Griffin, P. F., Rabey, I. M., Docherty, K., Riis, E., Arnold, A. S., Hinds, E. A.“…It has recently been shown that optical reflection gratings fabricated directly into an atom chip provide a simple and effective way to trap and cool substantial clouds of atoms (Nshii et al. in Nat Nanotechnol 8:321–324, 2013; McGilligan et al. in Opt Express 23(7):8948–8959, 2015). …”
Publicado 2016
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988“…The decrease of sequencing cost in the recent years has made genome-wide studies of transcription factor (TF) binding through chromatin immunoprecipitation methods like ChIP-seq and chromatin immunoprecipitation with lambda exonuclease (ChIP-exo) more accessible to a broader group of users. …”
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989“…On-chip cell culture devices have been actively developed for both mammalian cells and bacteria. …”
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990“…Some researchers have aimed to develop simple devices that interface with existing equipment and workflows, whilst others have aimed to integrate the entire FISH protocol into a fully autonomous FISH on-chip system. Whilst the technical possibilities for FISH on-chip are clearly demonstrated, only a small number of approaches have so far been converted into off-the-shelf products for wider use beyond the research laboratory.…”
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991por Yang, Jia-Wei, Shen, Yu-Chih, Lin, Ko-Chih, Cheng, Sheng-Jen, Chen, Shiue-Luen, Chen, Chong-You, Kumar, Priyank V., Lin, Shien-Fong, Lu, Huai-En, Chen, Guan-Yu“…This review paper focuses on integrating the important respiratory health problems caused by air pollution today, as well as the development and application of biomimetic organ-on-a-chip technology. This more precise experimental model is expected to accelerate studies elucidating the effect of PM on the human body and to reveal new opportunities for breakthroughs in disease research and drug development.…”
Publicado 2020
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992por Niu, Fuzhou, Chen, Xifu, Niu, Xuemei, Cai, Yifan, Zhang, Qingkui, Chen, Tao, Yang, Hao“…The chip was designed based on an S-shaped micromixer with embedded baffle. …”
Publicado 2020
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993
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994“…The emergence of in vivo-like in vitro models such as organ-on-chip (OOC) platforms can better recapitulate in vivo functions and responses and has the potential to move this field forward significantly. …”
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995“…The designed chip was tested for AST with E. coli samples, and the results were compared with conventional broth microdilution. …”
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996“…Thermoelectric harvesters, especially harvesters on-chip, have peculiar properties related to the thermal route, thermal transients, and spatial temperature distribution within the chip. …”
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997“…Comparison of various variants of the algorithms is made and recommendations on their application for the development of networks-on-chip with triple loop circulant topologies are given. …”
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998“…We then highlight the development of magnetic, colorimetric, plasmonic, electrical, and lateral flow-based lab-on-chip technologies for the detection of SARS-CoV-2, in addition to other viruses. …”
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999por Zhu, Lingxiao, Liu, Xuan, Sain, Basudeb, Wang, Mengyao, Schlickriede, Christian, Tang, Yutao, Deng, Junhong, Li, Kingfai, Yang, Jun, Holynski, Michael, Zhang, Shuang, Zentgraf, Thomas, Bongs, Kai, Lien, Yu-Hung, Li, Guixin“…Our work highlights the substantial progress toward fully integrated cold atom quantum devices by exploiting metasurface optical chips, which may have great potential in quantum sensing, quantum computing, and other areas.…”
Publicado 2020
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1000“…RESULTS: We introduced a simple model to simulate the mapped read-density of ChIP-seq and then derived the theoretical maximum and minimum of cross-correlation coefficients between strands. …”
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