“…The mechanism of action of dipeptidyl peptidase-4 inhibitors (DPP-4I) are relatively less clear although classical mechanism is to inhibit the endogenous GLP-1 metabolism and thereby increasing GLP-1 level in the physiological range. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moods and memories competed with each other; when positive moods prevailed over negative memories, people demonstrated classic mechanisms shown in prior work to influence well-being. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Despite recent advances in drug development, however, pharmacoresistance in epilepsy remains as high as 30%, suggesting the need for the development of new AEDs with a non-classical mechanism of action. Neuroinflammation is increasingly recognized as one of the key players in seizure generation and in the maintenance of the epileptic phenotype. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background and purpose — In the classical mechanical alignment technique, ligament balancing is considered a prerequisite for good function and endurance in total knee arthroplasty (TKA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTRODUCTION: Rigorous research in the last few years has shown that in addition to the classical mechanism of neurodegeneration, certain unconventional mechanisms may also lead to neurodegenerative disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Drug resistance always reduces the efficacy of chemotherapy, and the classical mechanisms of drug resistance include drug pump efflux and anti-apoptosis mediators-mediated non-pump resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These data support the idea that E. histolytica trophozoites trigger NETosis by a rapid non-classical mechanism and that different mechanisms of NETs release exist depending on the stimuli used.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On an international level, further research is required to better elucidate non-classical mechanisms of HPV exposure and transmission.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The first relied on a classical mechanical and chemical cell disruption to extract both intra- and extracellular DNA; the second included specific pre-treatments aimed at removing free DNA and DNA from human and damaged bacterial cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: OnabotulinumtoxinA (onabotA) is approved globally for prevention of chronic migraine; however, the classical mechanism of action of onabotA in motor and autonomic neurons cannot fully explain the effectiveness of onabotulinumtoxinA in this sensory neurological disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further, system-theoretic analysis reveals that the receptor systems are analogous to classical mechanical over-damped systems. This analogy enables us to metaphorically describe downregulation and desensitization as phenomena that make the systems more resilient in responding to ligand perturbations thereby improving the stability of the system resting state. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Here, we present strong indications that PTP gene family expansion occurred via classical mechanisms: by duplication of large segments of the chromosomally integrated form of the virus sequences (segmental duplication), by tandem duplications within this form and by dispersed duplications. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These findings represent a novel non-classical mechanism of Ang II signaling in cerebellar astrocytes.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MIF secretion in the first phase peaked at 60 min. and was inhibited by glyburide, indicating that this MIF pool was secreted by a non-classical mechanism and originated from pre-formed MIF stores. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These results demonstrate that ET-1 triggers classical mechanisms of vascular barrier dysfunction in ECs through ETA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These data reveal an unexpected ability of FhCL3, a helminth-derived molecule, to activate the NLRP3 inflammasome, which is independent of the classical mechanism involving caspase activation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results demonstrate the presence of a novel gain-of-function variant of Na(v)1.7 in a patient with adult-onset painful peripheral neuropathy and the responsiveness of that patient to treatment with CBZ, which is likely due to the classical mechanism of use-dependent inhibition.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of proline residues and subsequent proteasomal degradation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recent studies have shown how bacteria in the human gut microbiome produce toxins capable of altering the classical mechanisms of interaction of viruses with surface cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition to their classical mechanism of action through intracellular estrogen receptors (ERs), estrogens exert rapid actions via cell membrane-localized ERs (mERs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso