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1por Cuypers, Anne, Truong, Anh-Co Khanh, Becker, Lisa M., Saavedra-García, Paula, Carmeliet, Peter“…Tumor vessel co-option (VCO) is a non-angiogenic vascularization mechanism that is a possible cause of resistance to anti-angiogenic therapy (AAT). …”
Publicado 2022
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2por Mangione, Federica, Titlow, Joshua, Maclachlan, Catherine, Gho, Michel, Davis, Ilan, Collinson, Lucy, Tapon, NicolasEnlace del recurso
Publicado 2023
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4por Ren, Qian, Wang, Chunyang, Jin, Min, Lan, Jiangfeng, Ye, Ting, Hui, Kaimin, Tan, Jingmin, Wang, Zheng, Wyckoff, Gerald J., Wang, Wen, Han, Guan-Zhu“…These bivalve lysozyme genes underwent dramatic structural changes after their co-option, including intron gain and fusion with other genes. …”
Publicado 2017
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6“…Vessel co-option is the movement of cancer cells towards and along the pre-existing vasculature and is an alternative to angiogenesis to gain access to nutrients. …”
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7“…Unlike standard accounts of gene co‐option that identify component sources of evolutionary change, our model documents the cost‐benefit trade‐offs and thereby explains how one mechanism—an immediate response to acute stress—is transformed evolutionarily into another—routine protection from recurring stressors. …”
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8“…This lack of change (conservation) indicates that evolutionary novelties may arise more frequently through combinatorial processes, such as changes in gene regulation and the recruitment of novel genes into existing regulatory gene networks (co-option), and less often through adaptive evolutionary processes in the coding portions of a gene. …”
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10“…Accumulating evidence suggests that many human tumor types may use vessel co-option, which has profound implications for the use of anti-angiogenic agents for cancer treatment.…”
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11por Coelho, Ana Luísa, Gomes, Mónica Patrícia, Catarino, Raquel Jorge, Rolfo, Christian, Lopes, Agostinho Marques, Medeiros, Rui Manuel, Araújo, António Manuel“…Accumulating scientific data show that vessel co-option is an alternative mechanism to angiogenesis during tumor development in well-vascularized organs such as the lungs, where tumor cells highjack the existing vasculature to obtain its blood supply in a non-angiogenic fashion. …”
Publicado 2016
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12por Neal, Stephanie, McCulloch, Kyle J., Napoli, Francesca R., Daly, Christina M., Coleman, James H., Koenig, Kristen M.“…RESULTS: Here we identify the co-option of the canonical bilaterian limb patterning program during cephalopod lens development, a functionally unrelated structure. …”
Publicado 2022
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13por Carelli, Francesco Nicola, Cerrato, Chiara, Dong, Yan, Appert, Alex, Dernburg, Abby, Ahringer, Julie“…Our work reveals the emergence and evolutionary conservation of a novel transcriptional network driven by TE co-option with a major impact on regulatory evolution.…”
Publicado 2022
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14por Gasparotto, Erica, Burattin, Filippo Vittorio, Di Gioia, Valeria, Panepuccia, Michele, Ranzani, Valeria, Marasca, Federica, Bodega, BeatriceEnlace del recurso
Publicado 2023
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15por Huang, Hai-Jian, Li, Yi-Yuan, Ye, Zhuang-Xin, Li, Li-Li, Hu, Qing-Ling, He, Yu-Juan, Qi, Yu-Hua, Zhang, Yan, Li, Ting, Lu, Gang, Mao, Qian-Zhuo, Zhuo, Ji-Chong, Lu, Jia-Bao, Xu, Zhong-Tian, Sun, Zong-Tao, Yan, Fei, Chen, Jian-Ping, Zhang, Chuan-Xi, Li, Jun-MinEnlace del recurso
Publicado 2023
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16“…Our results indicate that evolution of protein function, co-option, and modularity are key elements in the evolution of bacterial morphology. …”
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18por de Almeida, Ana Maria Rocha, Yockteng, Roxana, Schnable, James, Alvarez-Buylla, Elena R., Freeling, Michael, Specht, Chelsea D.“…Over- or under- expression of either abaxializing or adaxializing genes inhibits laminar growth, resulting in a mutant radialized phenotype. Here, we show that co-option of the abaxial-adaxial polarity gene network plays a role in the evolution of stamen filament morphology in angiosperms. …”
Publicado 2014
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20“…CONCLUSIONS: Regardless of the developmental pathway, non-embryonic myogenesis shares a similar molecular and anatomical setup as embryonic myogenesis, but implements a co-option and loss of molecular modules. We then propose that the cellular precursors contributing to heart and body muscles may have different origins and may be coordinated by different developmental pathways. …”
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