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  1. 2461
    “…Colony forming assay was used to determine oncogenic transformation and double strand breaks (DSBs) were assessed by Comet assay. RESULTS: Despite differential MLH1 expression, both HCT116 and HCT116+chr3 cells displayed comparable high mutation rates (about 4×10(−4)) at [AAAG]17 repeats. …”
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    MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial Cells
  2. 2462
    “…DNA damage was measured by comet assay. Gene function was measured by cell viability, colony formation and apoptosis assays. …”
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    MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer
  3. 2463
    “…METHODS: In order to assess the toxicological impact of the engineered NMs on HK-2 cells - WST-1 cytotoxicity assay, FACSArray, HE oxidation and the comet assays were utilised. For statistical analysis, the experimental values were compared to their corresponding controls using an ANOVA with Tukey’s multiple comparison. …”
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    An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity
  4. 2464
    “…Dose-dependent DNA damage measured by comet-nuclear extract assay and flow cytometry-based γ-H2AX/propidium iodide (PI) analysis showed relatively severer damage in the Ca9-22 cells. …”
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    Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways
  5. 2465
    “…Since H(2)O(2) induces senescence through superoxide-induced DNA damage, we also observed the DNA damage by comet assay, and BK markedly reduced DNA damage induced by H(2)O(2), and moreover, BK treatment significantly prevented reactive oxygen species (ROS) production in H9C2 cells treated with H(2)O(2). …”
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    Bradykinin Inhibits Oxidative Stress-Induced Cardiomyocytes Senescence via Regulating Redox State
  6. 2466
    “…However, significant levels of cell death were not measured, suggesting that DNA repair was occurring. Comet assays showed that DNA repair was delayed in proportion to levels of genotoxic stress. …”
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    Indicators of replicative damage in equine tendon fibroblast monolayers
  7. 2467
    “…Different versions of the COMET assay were used to assess the genotoxicity of MPA-CdSe/ZnS QD. …”
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    CdSe/ZnS Quantum Dots trigger DNA repair and antioxidant enzyme systems in Medicago sativa cells in suspension culture
  8. 2468
    “…Single cell gel electrophoresis (comet assay) reveals that Cux1(+/−) MEFs are haploinsufficient for the repair of oxidative DNA damage, whereas elevated CUX1 levels accelerate DNA repair. …”
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    RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage
  9. 2469
    “…We designed an in vivo mouse model of hyperthermia/HS to induce a transient increase in ROS production in the brain. Comet and Terminal deoxyribonucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) assays demonstrated that Tau protected genomic DNA in adult cortical and hippocampal neurons in vivo under physiological conditions in wild-type (WT) and Tau-deficient (KO-Tau) mice. …”
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    A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
  10. 2470
    “…DNA damage in 3 T3-L1 fibroblasts was evaluated by the comet assay. The components in the extract were identified by HPLC and GC-MS. …”
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    Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration
  11. 2471
    “…Oxidative stress was assessed by spectrophotometric measurements of MDA and GSH levels while genotoxicity was determined by single cell gel electrophoresis (Comet assay). Apoptosis pathway was analyzed by Western blot analysis of Bax, Bcl2 and caspase 3 expression, as well as immunocytochemistry and confocal imaging of Bax and Cyt c translocation and mitochondrial membrane potential depolarization. …”
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    Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells
  12. 2472
    “…One study used lung sliding sign alone, 12 studies used lung sliding and comet tail signs, and 6 studies searched for lung point in addition to the other two signs. …”
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    Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis
  13. 2473
    “…METHODS AND ANALYSIS: Two biomarkers of early biological effects, DNA damage by the comet assay and the micronuclei (MN) test, will be investigated in oral mucosa cells of 6–8-year-old children. …”
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    Monitoring air pollution effects on children for supporting public health policy: the protocol of the prospective cohort MAPEC study
  14. 2474
    “…DNA damage types were then identified by comet assay and flow cytometric study was carried out to support the incidence of apoptosis. …”
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    Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells
  15. 2475
    “…Maternal blood samples (5–10 mL) were collected and processed for determination of oxidative DNA damage by the comet assay, using Fpg and Endo III enzymes. Urine samples were also collected for determination of 8-OHdG concentrations by ELISA. …”
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    Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women
  16. 2476
    “…METHODS: Genotoxicity was assessed using the comet assay on both cultured human lymphocytes and NCI-H460 cells, which had been exposed to MB or acriflavine before being illuminated at 660 or 488 nm, respectively. …”
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    Safety and performance analysis of acriflavine and methylene blue for in vivo imaging of precancerous lesions using fibered confocal fluorescence microscopy (FCFM): an experimental study
  17. 2477
    “…Maternal peripheral blood samples and umbilical cord blood samples (5–10 mL) were collected for genotyping by PCR-RFLP and for comet assays. RESULTS: The prevalence of genotype Gly/Arg in pregnant women groups was not statistically significant. …”
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    IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia
  18. 2478
    “…Meanwhile, Mcph1 deficiency impaired double strand break (DSB) repair in Mcph1(−/−)p53(−/−) MEFs as demonstrated by neutral Comet assay. Compared with Mcph1(+/+)p53(−/−) MEFs, homologous recombination and non-homologous end joining activities were significantly decreased in Mcph1(−/−)p53(−/−) MEFs. …”
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    Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model
  19. 2479
    “…Confocal microscopy with double immunofluorescence staining revealed that EB1 accumulates at the growing microtubule plus ends, where they exhibit a bright comet-like staining pattern in control astrocytes. …”
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    HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway
  20. 2480
    “…Employing the single-cell gel electrophoresis (comet) assay, we observed a potentiation of the TH-302 dependent tail moment. …”
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    Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
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