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  1. 2881
    “…METHODS: Sulforhodamine B (SRB) and the alkaline comet assays were done to study cell viability and DNA damage induction, respectively. …”
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    Induction of oxidative DNA damage, cell cycle arrest and p53 mediated apoptosis by calcium titanate nanoparticles in MCF-7 breast cancer cells
  2. 2882
    “…We were also able to estimate the efficiency of DNA repair through the DNA comet assay and gamma-H2AX staining. Possible ACTN4 effects on the non-homologous end joining (NHEJ) and homologous recombination (HR) were investigated using pathway-specific reporter plasmids and through the immunostaining of the key proteins. …”
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    Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells
  3. 2883
    “…DNA damage was assessed by comet assays. Changes in signalling pathways were detected via phospho-kinase array. western blotting was used to assess the molecular changes in endoplasmic reticulum (ER) stress and DNA damage. …”
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    Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
  4. 2884
    “…In addition, recommendations from other clinical initiatives such as COMET (Core Outcomes and Effectiveness Trials) and OMERACT (Outcome Measures in Rheumatology) have been adhered to. …”
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    Standardizing Cranioplasty Outcomes Following Stroke or Traumatic Brain Injury: Protocol for the Development of a Core Outcome Set
  5. 2885
    “…Outcomes were mapped onto the taxonomy developed by the COMET initiative. RESULTS: The systematic literature search identified 8043 potentially relevant publications on models of outpatient care for patients with chronic heart diseases. …”
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    An evidence map of systematic reviews on models of outpatient care for patients with chronic heart diseases
  6. 2886
    “…The mechanisms underlying drug addiction were elucidated through 5-bromo-2′-deoxyuridine (BrdU) incorporation assay, immunofluorescence staining, time-lapse microscopy, and comet assay. Furthermore, a subcutaneous xenograft model was used to demonstrate sotorasib addiction in vivo. …”
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    DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRAS(G12C)-mutant cancer
  7. 2887
    “…MATERIALS AND METHODS: The extent of DNA damage was assessed by the comet assay. The status of p-p38 MAPK, p-c-Jun N-terminal kinase, p-extracellular-signal regulating kinase (ERK), c-fos, c-jun, and endothelial growth factor receptor (EGFR) were analyzed by western blot and polymerase chain reaction techniques. …”
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    Evaluate the Antigenotoxicity and Anticancer Role of β-Sitosterol by Determining Oxidative DNA Damage and the Expression of Phosphorylated Mitogen-activated Protein Kinases’, C-fos, C-jun, and Endothelial Growth Factor Receptor
  8. 2888
    “…METHOD: To investigate the radiational enhancement of hsa-miR-138-2-3p, we transfected hsa-miR-138-2-3p mimics that were synthesized based on the sequences of hsa-miR-138-2-3p in vitrointo human laryngeal CSCs (Hep-2, M2e, and TU212 cell lines) to make hsa-miR-138-2-3p overexpressed, and the tumorous specialities of CSCs, like cell proliferation, invasion, apoptosis, cell cycle arrest, and DNA damage were evaluated by CCK-8 assay, clone formation assay, invasion assay, flow cytometry, and comet assay. Furthermore, we explored the signal transduction pathways that regulated the cancer stem cell initiation, development, invasion, apoptosis and cell cycle arrest, which were controlled by hsa-miR-138-2-3p. …”
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    Radiosensitization effect of hsa-miR-138-2-3p on human laryngeal cancer stem cells
  9. 2889
    “…Radiation-induced DNA damage and repair capacity was assessed using a comet assay. Differences between endogenous IDH1 mutant metabolism and that of IDH wildtype cells transduced with the IDH1 (R132H) mutation were also investigated. …”
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    Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
  10. 2890
    “…S.L. reports position funding from SpermComet Ltd. S.M. reports research grants, consulting and speaker’s fees from GSK, BMS/Pfizer, Sanquin, Aspen, Bayer and Daiichi Sankyo. …”
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    ESHRE guideline: recurrent pregnancy loss
  11. 2891
    “…METHODS: Human p53-mutated (p53-mut) and -wildtype (p53-wt) glioblastoma cell lines (p53-mut: LN405, T98G; p53-wt: A172, DBTRG) and primary glioblastoma cells (p53-mut: P0297; p53-wt: P0306) were treated with SAR combined with TMZ, 5-aza-dC, and/or IR and analysed for induction of apoptosis (AnnexinV and sub-G1 assay), cell cycle distribution (nuclear PI staining), DNA damage (alkaline comet or gH2A.X assay), proliferation inhibition (BrdU assay), reproductive survival (clonogenic assay), and potential tumour stem cells (nestin(pos)/GFAP(neg) fluorescence staining). …”
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    The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
  12. 2892
    “…In an in vitro model of aging, culturing human intestinal organoids for up to 2 months resulted in decreased telomere length and increased GH mRNA and protein expression associated with suppressed DNA damage response evident by decreased phosphorylation of ATM and DNA-PKcs, both kinases involved in DNA repair, and DNA damage accumulation assessed by Comet assay. Suppression of GH in these aging organoids led to increased phospho-p53 and reduced DNA damage. …”
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    OR16-06 Age-Associated Local GH Promotes Colon Neoplasia
  13. 2893
    “…DNA damage repair was analyzed in cultured cells using immunofluorescence and COMET assay. Results: Retention of Arid1a is critical for early progression of mutant Kras-driven pre-malignant lesions into PDAC, as evident by lower Ki-67 and higher apoptosis staining in “KAC” as compared to “KC” mice. …”
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    Paradoxical Role of AT-rich Interactive Domain 1A in Restraining Pancreatic Carcinogenesis
  14. 2894
    por Mahendran, Sophie A
    Publicado 2020
    “…Initial thoracic ultrasound scores were very low, with 70/74 calves scoring either 0 or 1, indicating few comet tails and no lung consolidation was seen and potential overdiagnosis of BRD. …”
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    Use of fever detection in combination with thoracic ultrasonography to identify respiratory disease, and compare treatments of antimicrobials and NSAID: a randomised study in dairy calves
  15. 2895
    “…Thyroid ultrasound consistent with a large left thyroid lobe lesion described as a complex solid component measures at least 5.2 cm long x 4.0 cm AP by 5.0 cm transverse with coarse scattered echogenic foci, and smaller bright echoes with comet-tail artifacts. Fine needle biopsy was non-diagnostic or unsatisfactory. …”
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    Incidental Poorly Differentiated Thyroid Cancer in Trauma Patient
  16. 2896
    por Smith, Matthew E., Hardman, John C., Mehta, Nishchay, Jones, Gareth H., Mandavia, Rishi, Anderson, Caroline, Khan, Maha, Abdelaziz, Aula, Al-Dulaimy, Bakir, Amin, Nikul, Anmolsingh, Rajesh, Anwar, Bilal, Bance, Manohar, Belfield, Katherine, Bhutta, Mahmood, Buchanan, Ruaridh, Chandrasekharan, Deepak, Chu, Michael, Chundu, Srikanth, Conroy, Katherine, Crundwell, Gemma, Daniel, Mat, Daniels, Jessica, De, Sujata, Dobbs, Sian, Doshi, Jayesh, Farr, Matthew, Ferdous, Tanjinah, Fragkouli, Eleni, Freeman, Simon, Ghosh, Samit, Gosnell, Emma, Hannan, S. Alam, Heward, Elliot, Javed, Faisal, John, Deepa, Nicholls, Helen, Kasbekar, Anand V., Khan, Haroon, Khan, Hammad, Khwaja, Sadie, Kotecha, Bhik, Krishnan, Madhankumar, Kumar, Nirmal, Lamb, Tamara, Lancer, Hannah, Manjaly, Joseph G., Martinez Del Pero, Marcos, McClenaghan, Fiona, Milinis, Kristijonas, Mistry, Nina, Mohammed, Hassan, Morris, Elizabeth, Morris-Jones, Stephen, Padee, Jessica, Pal, Surojit, Patel, Sanjay, Pericleous, Agamemnon, Qayyum, Asad, Rouhani, Maral, Saeed, Haroon, Santhiyapillai, Mirusanthan, Seymour, Kay, Sharma, Sunil, Siau, Richard, Singh, Arvind, Stapleton, Emma, Stephenson, Kate, Stynes, Gill, Subramanian, Bharathi, Summerfield, Neil, Swords, Chloe, Trinidade, Aaron, Tse, Antonia, Twumasi, Emmanuel, Ubhi, Harmony, Unadkat, Samit, Vijendren, Ananth, Wasson, Joe, Watson, Glen, Williams, Glennis, Wilson, Janet, Yao, Alexander, Youssef, Ahmed, Lloyd, Simon K. W., Tysome, James R.
    Publicado 2021
    “…STUDY DESIGN: COS development according to Core Outcome Measures in Effectiveness Trials (COMET) methodology and parallel consensus selection of diagnostic criteria/definition. …”
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    Acute otitis externa: Consensus definition, diagnostic criteria and core outcome set development
  17. 2897
    “…RESULTS: The raw mass spectra data searched against an in-house generated proteome database from UniProt using Comet search engine identified more than 300 proteins on the ejaculated buffalo sperm surface which were bound either by non-covalent (ionic) interactions or by a glycosylphosphatidylinositol (GPI) anchor. …”
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    Buffalo sperm surface proteome profiling reveals an intricate relationship between innate immunity and reproduction
  18. 2898
    “…The primary outcome of interest in the stage one searches will be studies which use PROMs to investigate HR-QOL as defined by the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy, the secondary outcome will be to assess the frequency of use of the various PROMs. …”
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    Evaluating measures of quality of life in adult scoliosis: a protocol for a systematic review and narrative synthesis
  19. 2899
    “…To increase COS uptake, it will also be actively shared with clinical guideline developers, research funders and the editors of general dental and endodontology journals. TRIAL REGISTRATION: COMET 1879. 21 May 2021.…”
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    A protocol for the Development of Core Outcome Sets for Endodontic Treatment modalities (COSET): an international consensus process
  20. 2900
    “…Metaphase chromosome spreading, immunofluorescence, and comet assays were used to access chromosome abnormalities and DSB formation. …”
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    Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation
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