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  1. 2921
    “…The involved molecular mechanisms were investigated by MDC staining, LC3 puncta formation assay, immunofluorescent assay, flow cytometric analysis of apoptosis and ROS, qRT-PCR, Western blot, comet assay, homologous recombination (HR) assay and immunohistochemical staining. …”
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    Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
  2. 2922
    “…Methods In vivo experiments in DNA stability (ladder, comet assay), free radicals attack (malondialdehyde; MDA, superoxide dismutase SOD, catalase gel-zymogram assay), extra cellular matrix damage (matrix metalloprotease; MMP2and9 zymogram assay) and inflammation (TNF-α, ELISA). …”
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    Effects of theaflavin-gallate in-silico binding with different proteins of SARS-CoV-2 and host inflammation and vasoregulations referring an experimental rat-lung injury
  3. 2923
    “…Functions of RETSAT were studied by means of DNA fiber assay and comet assay in monolayer cultured PDAC cell lines, three dimensional spheroids, patient derived organoids and cell derived xenograft mouse models. …”
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    RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma
  4. 2924
    “…Single- and double-stranded sperm DNA breaks were determined with alkaline and neutral Comet assays, respectively; ICSI was conducted following standard protocols and embryos were monitored through time-lapse microscopy. …”
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    Sperm DNA integrity does play a crucial role for embryo development after ICSI, notably when good-quality oocytes from young donors are used
  5. 2925
    “…To assess the levels of olaparib-induced DNA damage responses in miR-214-5P, transfected cells, immunoblots, and immunofluorescence assays were used. Furthermore, COMET assays were used to measure DNA lesions and colony assays were performed to assess the sensitivity of BRCA-proficient TNBC cells to olaparib. …”
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    Racial differences in RAD51 expression are regulated by miRNA-214-5P and its inhibition synergizes with olaparib in triple-negative breast cancer
  6. 2926
    “…The TopoGen decatenation kit was used to measure TopoIIα decatenation activity. Finally, a comet assay and metaphase chromosome spread were used to detect chromosome breakage and changes in chromosome condensation or numbers, respectively. …”
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    Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
  7. 2927
    “…N. fischeri (E3) induce cell death but in some cell lines without induction of DNA damage detected by comet assay. Crude ethyl extracts of N. laciniosa (E2) and N. fischeri (E3) exert an anticancer activity in human colon carcinoma, breast adenocarcinoma, and malignant melanoma cells. …”
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    Crude Extracts of Marine-derived and Soil Fungi of the Genus Neosartorya Exhibit Selective Anticancer Activity by Inducing Cell Death in Colon, Breast and Skin Cancer Cell Lines
  8. 2928
    por Young, Bridget, Bagley, Heather
    Publicado 2016
    “…The workshops were held in the United Kingdom, Italy and Canada as part of the COMET (Core Outcome Measures in Effectiveness Trials) Initiative annual meetings. …”
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    Including patients in core outcome set development: issues to consider based on three workshops with around 100 international delegates
  9. 2929
    “…Colony formation, β-gal staining, immunofluorescence, comet and homologous recombination (HR) assays and RNA-Seq analysis were used to determine the effects of AP4 inactivation. qPCR and qChIP analyses was performed to validate differentially expressed AP4 targets. …”
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    AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p
  10. 2930
    “…Tumor sphere formation assays and limiting dilution assays were applied to assess the implications of ARPC1B in tumorigenesis. Apoptosis, comet, γ-H2AX immunofluorescence (IF), and cell cycle distribution assays were used to evaluate the effect of ARPC1B on radiotherapy resistance. …”
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    ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells
  11. 2931
    “…Methods: Primary Pten-deficient (and corresponding wild-type) mouse embryonic fibroblasts (MEFs) and astrocytes and PTEN-null human tumor cell lines and primary cells were assessed for RAD51 expression (via the Western blot analysis) and DNA damage repair analyses (via alkali comet and γH2AX foci assays). RAD51 foci analysis was used to measure HR-dependent DNA repair. …”
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    RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status
  12. 2932
    “…OBJECTIVES: To evaluate the efficacy and safety of treatment with sotrovimab in high-risk, non-hospitalized patients with mild/moderate COVID-19, as part of the COMET-ICE clinical trial. METHODS: Multicenter, double-blind, phase 3 trial in non-hospitalized patients with symptomatic COVID-19 and ≥1 risk factor for disease progression were randomized 1:1 to an IV infusion of sotrovimab 500 mg or placebo. …”
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    502. Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab
  13. 2933
    “…BACKGROUND: There is a continued need for therapeutics for the treatment of COVID-19, including intramuscular (IM) agents, which will enable broader use across a variety of healthcare delivery settings. METHODS: COMET-PEAK (NCT04779879) is a 3-part study evaluating the safety, tolerability, pharmacokinetics (Part A), and viral pharmacodynamics (PD) of sotrovimab as treatment in adults ≥ 18 years with early mild/moderate COVID-19. …”
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    1154. Safety, Tolerability, and Viral Pharmacodynamics of the IgG Monoclonal Antibody Sotrovimab Administered via Intramuscular Injection for the Treatment of Early Mild-to-Moderate COVID-19
  14. 2934
    Tabla de Contenidos: “…Shenandoah crashes (1925) ; R-101 crashes (1930) ; Hindenburg explodes (1937) ; BOAC Comets explode (1954) ; Lockheed Electras crash (1959, 1960) ; United Airlines DC-8 and TWA Constellation collide (1960) ; American Airlines DC-10 crashes (1979) ; Japan Airlines Boeing 747 crashes (1985) ; United Airlines Boeing 747 explodes (1989) ; El Al Boeing 747-200 crashes (1992) ; Apollo 1 catches fire (1967) ; Soyuz 1 crashes (1967) ; Apollo 13 oxygen tank explodes (1970) ; Skylab's meteoroid shield fails (1973) ; Challenger explodes (1986) -- v. 2. …”
    Libro
    Failed technology : true stories of technological disasters /
  15. 2935
    “…Clinical information and mRNA expression datasets were downloaded from TCGA and COMETE databases. Based on eligibility criteria, 58 of 173 PC/PG samples in TCGA and 171 of 188 PC/PG samples collected by the COMETE network were selected. …”
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    Transcriptome Analysis Reveals Significant Differences in Gene Expression of Malignant Pheochromocytoma or Paraganglioma
  16. 2936
    “…There are four known sources of dust in the inner solar system: Jupiter Family comets, asteroids, Halley Type comets, and Oort Cloud comets. …”
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    Sources of cosmic dust in the Earth's atmosphere
  17. 2937
    “…To address this limitation, we have developed a tool that dynamically segments WGBS methylomes into blocks of comethylation (COMETs) from which lost information can be recovered in the form of differentially methylated COMETs (DMCs). …”
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    Information recovery from low coverage whole-genome bisulfite sequencing
  18. 2938
    “…VisANT is freely available at: http://visant.bu.edu and COMETS at http://comets.bu.edu.…”
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    Visualization of Metabolic Interaction Networks in Microbial Communities Using VisANT 5.0
  19. 2939
    “…Impacts by small solar system bodies (meteoroids, asteroids, comets and transitional objects) are characterized by a combination of energy dynamics and chemical modification on both terrestrial and small solar system bodies. …”
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    Glycine amino acid transformation under impacts by small solar system bodies, simulated via high-pressure torsion method
  20. 2940
    “…The dicarbon molecule (C(2)) is found in flames, comets, stars, and the diffuse interstellar medium. …”
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    Photodissociation of dicarbon: How nature breaks an unusual multiple bond
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