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681por Almeida, Mara Ribeiro, Darin, Joana D’Arc Castania, Hernandes, Lívia Cristina, de Souza Ramos, Mônica Freiman, Antunes, Lusânia Maria Greggi, de Freitas, Osvaldo“…As, there are few studies evaluating its genotoxicity, this aspect of the commercial oil-resin, and its volatile and resinous fractions, were evaluated in mice by comet assay and micronucleus (MN) test. A single dose of oil resin, volatile or resin fractions (500; 1,000 or 2,000 mg/kg b.w.) was administered by gavage. …”
Publicado 2012
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682por Padjas, Anna, Kedzierawski, Piotr, Florek, Agnieszka, Kukolowicz, Pawel, Kuszewski, Tomasz, Góźdz, Stanislaw, Lankoff, Anna, Wojcik, Andrzej, Lisowska, Halina“…DNA repair kinetics was performed with the alkaline comet assay following irradiation of unstimulated lymphocytes. …”
Publicado 2012
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683por Scalon, Madalena C. S., Rechenmacher, Ciliana, Siebel, Anna Maria, Kayser, Michele L., Rodrigues, Manoela T., Maluf, Sharbel W., Rodrigues, Marco Antonio S., Basso da Silva, Luciano“…The present study aimed to evaluate the physicochemical parameters and the genotoxic potential of water samples collected in the upper, middle, and lower courses of the Sinos River, southern Brazil. The comet assay was performed in the peripheral blood of fish Hyphessobrycon luetkenii exposed under laboratory conditions to water samples collected in summer and winter in three sampling sites of Sinos River. …”
Publicado 2013
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684por Gaddipati, Subhash, Muralidhar, R, Sangwan, Virender S, Mariappan, Indumathi, Vemuganti, Geeta K, Balasubramanian, Dorairajan“…COMET followed by optical-PK has improved visual acuity to 20/40 and rendered a stable ocular surface. …”
Publicado 2014
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685por Brunborg, Gunnar, Jackson, Petra, Shaposhnikov, Sergey, Dahl, Hildegunn, Azqueta, Amaya, Collins, Andrew R., Gutzkow, Kristine B.“…The comet assay is a sensitive and versatile method for assessing DNA damage in cells. …”
Publicado 2014
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686por Barbosa, Adriana Sierra Assencio Almeida, de Oliveira, Larissa Ragozo Cardoso, Tavares, Francilene Capel, de Lima, Carlos Roberto Gonçalves, Diório, Suzana Madeira, Calvi, Sueli Aparecida, Vilani-Moreno, Fátima Regina, Pereira, Paulo Câmara Marques“…CONCLUSION: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.…”
Publicado 2015
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687“…Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into two groups of 10 each, control- and tartrazine-treated groups. …”
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688Role of Macronutrients and Micronutrients in DNA Damage: Results From a Food Frequency Questionnaire“…This study investigates the influence of macronutrients (calories, protein, and glucides) and micronutrients, such as vitamins and minerals, as assessed by a food frequency questionnaire, on genotoxicity biomarkers measured by cytokinesis-blocked micronucleus assay and comet assay. The results found significant positive and negative correlations. …”
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689“…Abundant molecular oxygen was discovered in the coma of comet 67P/Churyumov–Gerasimenko. Its origin was ascribed to primordial gaseous O(2) incorporated into the nucleus during the comet's formation. …”
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690“…MATERIALS AND METHODS: The radiation antagonistic potential of RUT and QRT was assessed by alkaline comet and cytokinesis-block micronucleus (CBMN) assay. …”
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691por Tobólska, Sylwia, Terpiłowska, Sylwia, Jaroszewski, Jerzy, Siwicki, Andrzej Krzysztof“…The genotoxicity was determined by comet and micronucleus assays, and the mutagenicity was determined by Ames assay. …”
Publicado 2018
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692por Pieklarz, Katarzyna, Galita, Grzegorz, Tylman, Michał, Maniukiewicz, Waldemar, Kucharska, Ewa, Majsterek, Ireneusz, Modrzejewska, Zofia“…The cytotoxicity was verified based on the colorimetric resazurin assay, and the genotoxicity was checked by the comet assay (percentage of DNA in the comet tail). …”
Publicado 2021
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693por Wonok, Warin, Chaveerach, Arunrat, Siripiyasing, Pornnarong, Sudmoon, Runglawan, Tanee, Tawatchai“…The MTT assay showed no toxicity in all six of the studied species. The comet assay showed the key result that the ethanol extracts of Dd and Dg violently broke DNA into pieces. …”
Publicado 2021
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694“…Nevertheless, it is clearly evidenced that cancerogenic fluke-induced chronic inflammations and cancer are closely associated with oxidative stress. (1) Methods: The Paragonimus heterotremus infection’s genotoxic potential was assessed in a rat model of simultaneous pulmonary and hepatic paragonimiasis by the alkaline version of single-cell gel electrophoresis (comet assay). Statistical analysis of comet parameters was based on the non-parametric Mann–Whitney U test. (2) Results: A clear and statistically significant increase in DNA damage was detected in the helminth-exposed group versus the control rats and the tissue areas adjacent to the parasite capsule versus remote ones; however, differences in DNA damage patterns between different tissues were not statistically significant. …”
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695por Darwish, Hadeer, Al-Osaimi, Ghaida S., Al Kashgry, Najla Amin T., Sonbol, Hana, Alayafi, Aisha A. M., Alabdallah, Nadiyah M., Al-Humaid, Abdulrahman, Al-Harbi, Nadi Awad, Al-Qahtani, Salem Mesfir, Abbas, Zahid Khorshid, Darwish, Doaa Bahaa Eldin, Ibrahim, Mohamed F. M., Noureldeen, Ahmed“…In the present study, a comet assay test has been applied to evaluate the genotoxic impact of salinity at 0, 50, 100, and 200 mM of NaCl on C. aurantifolia tissue-cultured plants. …”
Publicado 2023
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696“…TRIAL REGISTRATION NUMBERS: NCT00195494 (COMET) and NCT00393471 (TEMPO).…”
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697por Tallouzi, Mohammad O., Mathers, Jonathan M., Moore, David J., Murray, Philip I., Bucknall, Nicholas, Blazeby, Jane M., Calvert, Melanie, Denniston, Alastair K.“…A COS for PSIU would allow greater comparison and aggregation of data across trials for the better evaluation of established and emerging therapies through evidence synthesis and meta-analysis to inform clinical guidelines and health policy. TRIAL REGISTRATION: COMET. http://comet-initiative.org/studies/details/640. …”
Publicado 2017
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698por Bourbeau, Jean, Granados, Denis, Roze, Stéphane, Durand-Zaleski, Isabelle, Casan, Pere, Köhler, Dieter, Tognella, Silvia, Viejo, Jose Luis, Dal Negro, Roberto W, Kessler, Romain“…This analysis aimed to evaluate the cost-effectiveness of a home-based disease management (DM) intervention vs usual management (UM) in patients from the COPD Patient Management European Trial (COMET). METHODS: Cost-effectiveness was evaluated in 319 intention-to-treat patients over 12 months in COMET. …”
Publicado 2019
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699por Younes, Maged, Aquilina, Gabriele, Castle, Laurence, Engel, Karl‐Heinz, Fowler, Paul, Frutos Fernandez, Maria Jose, Fürst, Peter, Gundert‐Remy, Ursula, Gürtler, Rainer, Husøy, Trine, Moldeus, Peter, Oskarsson, Agneta, Shah, Romina, Waalkens‐Berendsen, Ine, Wölfle, Detlef, Benigni, Romualdo, Bolognesi, Claudia, Chipman, Kevin, Cordelli, Eugenia, Degen, Gisela, Marzin, Daniel, Svendsen, Camilla, Carfì, Maria, Vianello, Giorgia, Mennes, Wim“…Two additional in vivo comet assays in liver were performed in order to clarify the potential impact of peroxides on the obtained results from the genotoxicity testing. …”
Publicado 2019
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700por Younes, Maged, Aquilina, Gabriele, Castle, Laurence, Engel, Karl‐Heinz, Fowler, Paul, Frutos Fernandez, Maria Jose, Fürst, Peter, Gundert‐Remy, Ursula, Husøy, Trine, Mennes, Wim, Moldeus, Peter, Oskarsson, Agneta, Rainieri, Sandra, Shah, Romina, Waalkens‐Berendsen, Ine, Wölfle, Detlef, Binderup, Mona‐Lise, Bolognesi, Claudia, Marcon, Francesca, Marzin, Daniel, Mosesso, Pasquale, Anastassiadou, Maria, Carfì, Maria, Vianello, Giorgia, Gürtler, Rainer“…In addition, 2‐methylcrotonaldehyde [FL‐no: 05.095] tested in an in vivo comet assay in liver and duodenum, it did not induce DNA damage. …”
Publicado 2018
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