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741por Mbemi, Ariane T., Sims, Jennifer N., Yedjou, Clement G., Noubissi, Felicite K., Gomez, Christian R., Tchounwou, Paul B.“…Data obtained from the comet assay showed a significant increase (p < 0.05) in the percentages of DNA cleavage and comet tail length. …”
Publicado 2020
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742por Yamamoto, Hiroki, Fukasawa, Yuki, Shoji, Yu, Hisamoto, Shumpei, Kikuchi, Tomohiro, Takamatsu, Atsuko, Iwasaki, Hideo“…As cells increased and bundles aggregated, comet-like wandering clusters developed. The direction and velocity of the movement of cells in comet-like wandering clusters were highly coordinated. …”
Publicado 2021
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743“…/day, and induced dose-dependent increases in % DNA in the tail and tail moment on in vivo comet assay. CONCLUSIONS: Six out of eight food colorants did not cause genotoxicity and cytotoxicity. …”
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744“…Genome stability was analyzed using the sister chromatid exchange, fragile site, and comet assays. The effects of selected micro- and macroelements and vitamins on the levels of chromosomal instabilities generated in the cows were analyzed. …”
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745por Ventura, Célia, Pinto, Fátima, Lourenço, Ana Filipa, Pedrosa, Jorge F. S., Fernandes, Susete N., da Rosa, Rafaela R., Godinho, Maria Helena, Ferreira, Paulo J. T., Louro, Henriqueta, Silva, Maria João“…For that, we exposed co-cultures of human alveolar epithelial A549 cells and THP-1 monocyte-derived macrophages to a concentration range of each CMNM and used the micronucleus (MN) and comet assays. Our results showed that only the lowest concentrations of the CMF sample were able to induce DNA strand breaks (FPG-comet assay). …”
Publicado 2023
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746por Tamaddon, Ali Mohammad, Bashiri, Rahman, Najafi, Haniyeh, Mousavi, Khadijeh, Jafari, Mahboobeh, Borandeh, Sedigheh, Aghdaie, Mahdokht H., Shafiee, Mina, Abolmaali, Samira Sadat, Azarpira, Negar“…The annexin V staining procedure was used to determine apoptotic and necrotic death. In addition, COMET and karyotyping techniques were used to assess the extent of DNA and chromosome damage. …”
Publicado 2023
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747por Valverde, Mahara, Granados, Adriana, Milić, Mirta, Ceppi, Marcello, Sollano, Leticia, Bonassi, Stefano, Rojas, Emilio“…These results highlight the sensitivity of the comet assay in identifying differential in utero exposure for newborns whose mothers were exposed during pregnancy. …”
Publicado 2023
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748“…Other cytological features such as comet cells and cells with India ink nuclei are also helpful for diagnosis but have limited value because they are less frequently seen.…”
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749por Unger, Florian T, Klasen, Hermann A, Tchartchian, Garri, de Wilde, Rudy L, Witte, Irene“…RESULTS: While in the comet assay the isolated cells showed a high degree of DNA damage after a 24 h treatment, cell viability revealed no cytotoxicity after that incubation time. …”
Publicado 2009
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750por Grisolia, Cesar K., Rivero, Carla L. G., Starling, Fernando L. R. M., da Silva, Izabel C. R., Barbosa, Antonio C., Dorea, Jose G.“…However, Steindachnerina insculpita (a detritivorous and lake-floor feeder species) showed the highest index of DNA damage in the comet assay, followed by C. temensis (piscivorous). …”
Publicado 2009
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751por Wu, Han, Zhang, Huina, Wang, Changjun, Wu, Yihua, Xie, Jiajun, Jin, Xiuming, Yang, Jun, Ye, Juan“…DNA damage to HCEs was examined by alkaline comet assay and by immunofluorescence microscopic detection of the phosphorylated form of histone variant H2AX (γH2AX) foci. …”
Publicado 2011
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752por Szczepanska, Joanna, Poplawski, Tomasz, Synowiec, Ewelina, Pawlowska, Elzbieta, Chojnacki, Cezary J., Chojnacki, Jan, Blasiak, Janusz“…Results from the neutral comet assay indicated that both compounds induced DNA double strand breaks (DSBs) and they were confirmed by the γ-H2AX assay. …”
Publicado 2011
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753por Amador, Rubem R., Longo, João Paulo Figueiró, Lacava, Zulmira G., Dórea, José G., Almeida Santos, Maria de Fátima M.“…We tested metformin genotoxicity in cells of Chinese hamster ovary, CHO-K1 (chromosome aberrations; comet assays) and in mice (micronucleus assays). …”
Publicado 2012
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754“…Their comet assay and histopathological examination revealed that riboflavin in combination with cisplatin was able to protect the tissues from cisplatin induced toxicities and damages. …”
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755por Angelieri, Fernanda, Joias, Renata P., Bresciani, Eduardo, Noguti, Juliana, Ribeiro, Daniel A.“…The genotoxicity and cytotoxicity were evaluated by means of the single cell gel (Comet Assay) and the trypan blue exclusion test, respectively. …”
Publicado 2012
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756por Dias, Elsa, Louro, Henriqueta, Pinto, Miguel, Santos, Telma, Antunes, Susana, Pereira, Paulo, Silva, Maria João“…In this work, we used the comet and/or the micronucleus (MN) assays to study the genotoxicity of MCLR in kidney- (Vero-E6) and liver-derived (HepG2) cell lines and in blood cells from MCLR-exposed mice. …”
Publicado 2014
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757por Mattana, C. M., Cangiano, M. A., Alcaráz, L. E., Sosa, A., Escobar, F., Sabini, C., Sabini, L., Laciar, A. L.“…The genotoxicity was tested by the single-cell gel electrophoresis comet assay. The results obtained in the evaluation of DNA cellular damage exposed to varied concentrations of the HAE showed no significant genotoxic effect at range of 1–20 mg/mL. …”
Publicado 2014
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758“…All of the samples protected against H(2)O(2)-induced DNA damage in human leukocytes, as measured by the comet assay, but the acetone extracts of OP had the strongest effect. …”
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759“…Data generated from the Comet assay demonstrated a significant dose-dependent increase in genotoxicity with respect to DNA damage as a result of cisplatin treatment. …”
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760“…DNA damage was determined bases on the percentage of DNA in a comet tail (tail DNA), under the influence of silver complex in different concentrations. …”
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