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761por Li, Tianxin, Zhang, Minjie, Gu, Ke, Herman, Uwizeyimana, Crittenden, John, Lu, Zhongming“…These findings support the suitability and sensitivity of the comet assay for surveying plants for an estimation of DNA damage induced by environmental genotoxic agents. …”
Publicado 2016
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762por Zedginidze, Alla, Namchevadze, Ema, Ormocadze, George, Kapanadze, Archil, Nikuradze, Tamara, Lomidze, Darejan“…Clinical examination, chromosomal analysis, and assay of DNA damage by the comet (single-cell gel electrophoresis) assay were carried out. …”
Publicado 2016
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763por Schulz, Nadine, Chaachouay, Hassan, Nytko, Katarzyna J., Weyland, Mathias S., Roos, Malgorzata, Füchslin, Rudolf M., Guscetti, Franco, Scheidegger, Stephan, Rohrer Bley, Carla“…It was possible to follow dynamics of comet tail intensity and γH2AX-foci during a course of radiation using a minimally invasive approach. …”
Publicado 2017
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764por Koyuncu, Ismail, Kocyigit, Abdurrahim, Gonel, Ataman, Arslan, Erkan, Durgun, Mustafa“…We used 8-OHdOG as a marker for DNA damage in serum via ELISA and in PMBC via comet assay. Treatment with Cis elevated the levels of serum biochemical parameters, oxidative stress, and DNA damage. …”
Publicado 2017
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765por Maronpot, Robert R., Hobbs, Cheryl A., Davis, Jeffrey, Swartz, Carol, Boyle, Molly, Koyanagi, Mihoko, Hayashi, Shim-mo“…No induction of DNA damage was detected in male or female mouse liver, stomach, or duodenum in the comet assay. Sodium sulfate also tested negative in these same genotoxicity assays. …”
Publicado 2016
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766“…Oil exposure during the cleaning tasks has caused an increase in the genotoxic damage in individuals, the comet assay being the most sensitive biomarker to detect it. …”
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767“…After 14 days of exposure, the MN and NA frequencies were significantly increased in peripheral blood of the TCS-treated groups compared with the solvent control, and the comet tail moment and MDA in the liver in the highest dose of TCS groups were also significantly high. …”
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768por Ardeshir, Rashid Alijani, Zolgharnein, Hossein, Movahedinia, Abdolali, Salamat, Negin, Zabihi, Ebrahim“…Multiple regression analysis showed that the CYP1A had the most correlation with the organ-somatic index (R(2) = 0.76) and comet tail (R(2) = 0.89) in the liver, and with DTC (R(2) = 0.93) and oxidative stress (R(2) = 0.87) in the kidney. …”
Publicado 2017
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769por Yang, Jing-Iong, Yeh, Chi-Chen, Lee, Jin-Ching, Yi, Szu-Cheng, Huang, Hurng-Wern, Tseng, Chao-Neng, Chang, Hsueh-Wei“…The AEGT also suppressed H(2)O(2)-induced oxidative DNA damage in H1299 cells by reducing the percentage of damaged DNA in a dose-response manner (P < 0.001) as measured by a modified alkaline comet-nuclear extract (comet-NE) assay. The MTT assay results showed that AEGT confers significant protection against H(2)O(2)-induced cytotoxicity and that AEGT itself is not cytotoxic (P < 0.001). …”
Publicado 2012
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770“…Comparisons of BDSKY with the single‐pulse Bayesian model, CoMET, showed a similar frequency of Type II error and neither model exhibited Type I error. …”
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771por Fernández, Rafael, Berruecos, Carolina, Motta, María Catalina cortés, Velásquez, Diego“…Fibrinogen formation was low for both materials, and DNA damage induction was not observed in a comet assay.…”
Publicado 2018
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772por Aichinger, Georg, Lichtenberger, Falk-Bach, Steinhauer, Tamara N., Flörkemeier, Inken, Del Favero, Giorgia, Clement, Bernd, Marko, Doris“…Potentially resulting DNA damage was analyzed by single-cell gel electrophoresis (“comet assay”). Already at 1 h of incubation, significant genotoxic effects were observed in the comet assay in concentrations as low as 1 nM. …”
Publicado 2020
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773por Paraš, Smiljana, Trišić, Dijana, Mitrović Ajtić, Olivera, Prokić, Bogomir, Drobne, Damjana, Živković, Slavoljub, Jokanović, Vukoman“…Therefore, we performed a comet assay on human monocytes for in vitro genotoxicity investigation, and the systemic subchronic toxicity investigation on rats being per oral feed with exactly administrated extract quantities of the nano calcium hydroxyapatite covered with tiny layers of PLGA (ALBO-OS) for 120 days. …”
Publicado 2020
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774por Cabral, Joao Victor, Jackson, Catherine Joan, Utheim, Tor Paaske, Jirsova, Katerina“…This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.…”
Publicado 2020
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775“…Histopathological analysis and comet assay further consolidate these results. Hence, RF has significant alleviative property against PB-induced hepatotoxicity in vivo that can be used in the consumer items containing the toxicant.…”
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776por Muhammad, Hussin, Omar, Maizatul Hasyima, Rasid, Elda Nurafnie Ibnu, Suhaimi, Shazlan Noor, Mohkiar, Farah Huda, Siu, Lau Mei, Awang, Norizah“…The DNA damage of V79B cells was measured using the alkaline comet assay treated at 0.1 mg/mL (IC10) and 0.3 mg/mL (IC25) of FDAE together with positive and negative controls. …”
Publicado 2021
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777por Asghari, Fatemeh, Ebrahimnejad Gorji, Kourosh, Mozaffarpur, Seyyed Ali, Shabestani Monfared, Ali, Zabihi, Ebrahim, Abedian, Zeinab, Shirafkan, Hoda, Niksirat, Fatemeh, Borzoueisileh, Sajad“…In this study, we aimed to evaluate the possible association between Mizaj and radiosensitivity by comet assay. MATERIALS AND METHODS: Peripheral blood sample of 30 healthy volunteers (10 cold, 11 moderate and nine warm Mizaj) were taken and divided into two identical parts. …”
Publicado 2020
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778por Gillies, Katie, Williamson, Paula R, Entwistle, Vikki A, Gardner, Heidi, Treweek, Shaun, Campbell, Marion K“…Use of the ELICIT core set will ensure that results from these trials are comparable and relevant to all stakeholders. REGISTRATION: COMET database - http://www.comet-initiative.org/Studies/Details/595.…”
Publicado 2021
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779por Colafarina, Sabrina, Di Carlo, Piero, Zarivi, Osvaldo, Aloisi, Massimo, Di Serafino, Alessandra, Aruffo, Eleonora, Arrizza, Lorenzo, Limongi, Tania, Poma, Anna“…The viability of A549 and Hs27 cells at 48 and 72 h of exposure to silica or silica/ozone decreases, except at 72 h in Hs27 treated with silica/ozone. The micronucleus and comet tests showed a significant increase in the number of micronuclei and the % of DNA in the queue, compared to the control, in both lines in all treatments, even if in different cell times/types. …”
Publicado 2022
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780“…Most genotoxicity studies performed on NPs have focused on primary genotoxicity analyzed by comet- or micronuclei (MN) assay using microscopic scoring. …”
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