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Mostrando 901 - 920 Resultados de 3,134 Para Buscar '"comet"', tiempo de consulta: 0.20s Limitar resultados
  1. 901
    “…Outcomes coded using the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy. RESULTS: Three hundred and thirty three papers found on searching. …”
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    A scoping review to identify process and outcome measures used in acceptance and commitment therapy research, with adults with acquired neurological conditions
  2. 902
    “…Additionally, DNA double-strand breaks were observed in the alkaline comet assay. DNA damage, apoptosis, and autophagy induction could be attributed to the inhibition of c-MYC by ELI-XXIII-98-2.…”
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    The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells
  3. 903
    “…STUDY REGISTRATION: The study is registered with the COMET initiative: https://www.comet-initiative.org/studies/details/1406.…”
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    A protocol for the development of core outcome sets for effectiveness trials and clinical audits in renal cell cancer (R‐COS)
  4. 904
    “…Genotoxic and mutagenic effects were evaluated by the comet and micronucleus assays, respectively. The hemolytic action of the compounds was evaluated. …”
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    Anti-Hyperuricemic, Anti-Arthritic, Hemolytic Activity and Therapeutic Safety of Glycoconjugated Triazole-Phthalimides
  5. 905
    “…Neutral comet assay has been available for two decades to evaluate sperm double-strand breaks (DSBs). …”
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    Innovative technology for evaluation of sperm DNA double-strand breaks diagnoses male factor infertility and prevents reproductive failures
  6. 906
    “…Results from the proteomic analysis were confirmed via ICP-MS, cell-cycle analysis, and comet assays. RESULTS: Single entinostat- or chemotherapy significantly reduced cell viability in human neuroendocrine SCLC cells. …”
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    Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
  7. 907
    “…Mouse sperm were treated with varying concentrations of either H(2)O(2) or MnCl(2), and the DNA damage was assessed by pulse-field gel electrophoresis, and the alkaline and neutral comet assays. Oocytes were injected with either treated sperm and the resulting embryos analyzed with an embryoscope to detect subtle changes in embryonic development. …”
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    Low levels of mouse sperm chromatin fragmentation delay embryo development
  8. 908
    por Olive, P. L.
    Publicado 1995
    “…Using both the alkaline and neutral versions of the comet assay, at least 20 times more single-strand breaks were observed in cells from fully anoxic than fully oxic Chinese hamster V79 spheroids exposed to 30 microM tirapazamine, and about 10 times more single- than double-strand breaks were observed. …”
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    Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine.
  9. 909
    “…Primary DNA damage was evaluated by the alkaline comet assay in peripheral blood leukocytes. Genetic polymorphisms for CYP1A1, EPHX and GSTM1 were determined by PCR or PCR/RFLP analysis. …”
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    Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant
  10. 910
    “…The single-cell gel electrophoresis (comet) assay was used to measure radiation-produced DNA double-strand breaks (dsbs) in a series of seven cervical tumour cell lines (ME180, HT3, C33A, C41, SiHa, MS751 and CaSki). …”
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    The ratio of initial/residual DNA damage predicts intrinsic radiosensitivity in seven cervix carcinoma cell lines.
  11. 911
    “…Initial damage measured after 2 Gy using the alkaline comet assay gave a close correlation with SF(2) (r(2)=0.95), whereas there was no correlation between initial DNA damage repair rate and SF(2).…”
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    Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells
  12. 912
    “…CONCLUSION: These results: a) demonstrate that CoMet is a valuable method to identify potential compounds for experimental validation, b) indicate that cancer cell metabolism may be regulated to reduce the intracellular concentration of certain antiproliferative metabolites, leading to uninhibited cellular growth and c) suggest that many other endogenous metabolites with important roles in carcinogenesis are awaiting discovery.…”
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    Identification of metabolites with anticancer properties by computational metabolomics
  13. 913
    “…Apoptosis and cell survival were then assessed by various methods including COMET assay, LIVE/DEAD Cytotoxicity/Viability assay and colony formation assay. …”
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    NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
  14. 914
    “…Logistic regression analysis model explained a deviance of 72% (p < 0.0001), directly related with the mean percentage of rapid spermatozoa in fresh semen (p < 0.01), semen viability after thawing (p < 0.01), and with two of the three comet parameters considered, i.e tail DNA percentage and comet length (p < 0.0001). …”
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    Semen molecular and cellular features: these parameters can reliably predict subsequent ART outcome in a goat model
  15. 915
    “…The viability, motility, DNA integrity by comet assay and acrosome integrity by fluorescein isothiocyanate-conjugated peanut agglutinin (FITC-PNA) staining of frozen-thawed spermatozoa of each group were compared. …”
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    On-Chip Cryopreservation: A Novel Method for Ultra-Rapid Cryoprotectant-Free Cryopreservation of Small Amounts of Human Spermatozoa
  16. 916
    “…To further explore the molecular mechanism through which ST induces G(2) arrest, the current study was designed to precisely dissect the role of DNA damage and the DNA damage sensor ataxia telangiectasia-mutated (ATM)/p53-dependent pathway in the ST-induced G(2) arrest in GES-1 cells. Using the comet assay, we determined that ST induces DNA damage, as evidenced by the formation of DNA comet tails, in GES-1 cells. …”
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    Sterigmatocystin-Induced DNA Damage Triggers G(2) Arrest via an ATM/p53-Related Pathway in Human Gastric Epithelium GES-1 Cells In Vitro
  17. 917
    “…Cytotoxicity by fluorescein-diacetate staining and COMET assay generating single strand DNA cleavage, tail length and tail moment measurements were examined. …”
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    Effect of Light Irradiation and Sex Hormones on Jurkat T Cells: 17β-Estradiol but Not Testosterone Enhances UVA-Induced Cytotoxicity in Jurkat Lymphocytes
  18. 918
    “…BACKGROUND: The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. …”
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    Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice
  19. 919
    “…METHODS: Amnion cells isolated from fetal membranes were exposed to wsCSE prepared in cell culture medium and changes in ROS levels, DNA base and strand damage was determined by using 2′7′-dichlorodihydro-fluorescein and comet assays as well as Fragment Length Analysis using Repair Enzymes (FLARE) assays, respectively. …”
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    Senescence of Primary Amniotic Cells via Oxidative DNA Damage
  20. 920
    “…METHODS: DNA damage was analyzed in PBLs of 45 EC patients compared to a control group of 10 healthy women, using the comet assay. The level of DNA damage was determined by the% tail DNA. …”
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    DNA repair deficiency in peripheral blood lymphocytes of endometrial cancer patients with a family history of cancer
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