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921“…DNA damage was assessed in the HeLa and MS751 cells using alkaline comet assays and by detection of γH2AX focus formation. …”
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922por Kwon, Jee Young, Kim, Hye Lim, Lee, Jong Yun, Ju, Yo Han, Kim, Ji Soo, Kang, Seung Hun, Kim, Yu-Ri, Lee, Jong-Kwon, Jeong, Jayoung, Kim, Meyoung-Kon, Maeng, Eun Ho, Seo, Young Rok“…RESULTS: No statistically significant differences were found in the bacterial mutation assay, in vitro chromosomal aberration test, in vivo comet assay, and in vivo micronucleus test when tested for induction of genotoxicity in both two types of SiO(2) nanoparticles. …”
Publicado 2014
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923por Kyjovska, Zdenka O, Jacobsen, Nicklas R, Saber, Anne T, Bengtson, Stefan, Jackson, Petra, Wallin, Håkan, Vogel, Ulla“…DNA strand breaks in BAL cells, lung, and liver tissue were assessed using the alkaline comet assay. The pulmonary acute phase response was analyzed by Saa3 mRNA real-time quantitative PCR. …”
Publicado 2015
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924por Dumax-Vorzet, Audrey F., Tate, M., Walmsley, Richard, Elder, Rhod H., Povey, Andrew C.“…Urban dust and DEP produced comparable levels of DNA damage, as assessed by the alkaline comet assay, in MEFs at higher levels than those induced by Manchester PM. …”
Publicado 2015
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925“…Data generated from the comet assay indicated a concentration-dependent increase in DNA damage, showing a significant increase (p < 0.05) in comet tail-length and percentages of DNA cleavage. …”
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926“…Data obtained from the Comet assay indicated that cadmium chloride causes DNA damage in HepG(2) cells in a concentration-dependent manner. …”
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927por Yang, Shu-mei, Tsai, Kuen-daw, Wong, Ho-Yiu, Liu, Yi-Heng, Chen, Ta-Wei, Cherng, Jonathan, Hsu, Kwang-Ching, Ang, Yao-Uh, Cherng, Jaw-Ming“…Specifically, cell viability was evaluated by colorimetric assay; cytotoxicity by LDH release; apoptosis was determined by Western blotting, and morphological analysis with, acridine orange and neutral red stainings and comet assay; topoisomerase I activity was assessed using assay based upon DNA relaxation and topoisomerase II by DNA relaxation plus decatentation of kinetoplast DNA; lysosomal vacuolation and volume of acidic compartments (VAC) were evaluated with neutral red staining. …”
Publicado 2016
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928por Balbous, Anaïs, Cortes, Ulrich, Guilloteau, Karline, Rivet, Pierre, Pinel, Baptiste, Duchesne, Mathilde, Godet, Julie, Boissonnade, Odile, Wager, Michel, Bensadoun, René Jean, Chomel, Jean-Claude, Karayan-Tapon, Lucie“…METHODS: DNA damage was quantified by Comet assay and DNA repair effectors were assessed by Low Density Array. …”
Publicado 2016
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929por Larsen, Søren T., Jackson, Petra, Poulsen, Steen S., Levin, Marcus, Jensen, Keld A., Wallin, Håkan, Nielsen, Gunnar D., Koponen, Ismo K.“…As the only particles, ZnO caused a significant toxic effect in the airways while TiO(2) gave rise to DNA-strand break as shown by the comet assay.…”
Publicado 2016
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930por Freitas de Lima, Fernando, Lima Tolouei Menegati, Sara Emilia, Karenina Traesel, Giseli, Souza de Araújo, Flávio Henrique, Honaiser Lescano, Caroline, Moraes Peixoto, Sara, Mao Silva, Felipe Ariel, Heredia Vieira, Silvia Cristina, do Carmo Vieira, Maria, Oesterreich, Silvia Aparecida“…When compared to the positive control group, all groups (comet and micronucleus tests) were statistically different. …”
Publicado 2016
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931por de Moraes Filho, Aroldo Vieira, Carvalho, Cláudia de Jesus Silva, Carneiro, Cristiene Costa, do Vale, Camila Regina, Lima, Débora Cristina da Silva, Carvalho, Wanessa Fernandes, Vieira, Thiago Bernardi, Silva, Daniela de Melo e, Cunha, Kênya Silva, Chen-Chen, Lee“…Neither TDF + 3TC nor combivir + EFV induced DNA damage at any concentrations tested after 24 h or 48 h using the comet assay. After 24 h, both combinations increased the micronucleus frequency at all concentrations tested. …”
Publicado 2016
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932por Varasteh-kojourian, Maryam, Abrishamchi, Parvaneh, Matin, Maryam M., Asili, Javad, Ejtehadi, Hamid, Khosravitabar, Fatemeh“…Leaf extract of A. biebersteinii was not cytotoxic even at the highest examined dose (512 µg/ml) and inhibited cell toxicity induced by H(2)O(2) (98% viability for the cells pretreated with plant extract in the presence of H(2)O(2)). Comet assay also confirmed high DNA protective activity of leaf extracts. …”
Publicado 2017
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933por Paget, Sonia, Dubuissez, Marion, Dehennaut, Vanessa, Nassour, Joe, Harmon, Brennan T., Spruyt, Nathalie, Loison, Ingrid, Abbadie, Corinne, Rood, Brian R., Leprince, Dominique“…HIC1 is also essential for DSB repair as silencing of endogenous HIC1 in BJ-hTERT fibroblasts significantly delays DNA repair in functional Comet assays. HIC1 SUMOylation favours its interaction with MTA1, a component of NuRD complexes. …”
Publicado 2016
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934por Lamont, Thomas J., Clarkson, Jan E., Ricketts, David N. J., Heasman, Peter A., Ramsay, Craig R.“…We will actively disseminate our findings to help improve clinical trials, systematic reviews and clinical guidelines with the ultimate aim of improving the prevention and management of periodontal diseases. TRIAL REGISTRATION: COMET (http://www.comet-initiative.org/studies/details/265?…”
Publicado 2017
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935por Sherratt, Frances C, Eaton, Simon, Walker, Erin, Beasant, Lucy, Blazeby, Jane M, Young, Bridget, Crawley, Esther, Wood, Wendy W, Hall, Nigel J“…The COS development study is registered with the COMET Initiative in May 2017 (http://www.comet-initiative.org/studies/details/987).…”
Publicado 2017
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936por Nielsen, Karoline Kragelund, O’Reilly, Sharleen, Wu, Nancy, Dasgupta, Kaberi, Maindal, Helle Terkildsen“…The inclusion of multiple stakeholder perspectives will increase the final COSs applicability and relevance. TRIAL REGISTRATION: Comet Initiative, COMET 1083; PROSPERO, CRD42018084853. …”
Publicado 2018
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937por Li, Geng, Zhou, Li, Ouyang, Wenwei, Xuan, Meiling, Lu, Liming, Li, Xiaoyan, Wen, Zehuai, Chen, Xiankun“…TRIAL REGISTRATION: The Core Outcome Measures in Effectiveness Trials Initiative (COMET): http://www.comet-initiative.org/studies/details/983. …”
Publicado 2019
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938por Nam, Ah-Rong, Jin, Mei Hua, Park, Ji Eun, Bang, Ju-Hee, Oh, Do-Youn, Bang, Yung-Jue“…MATERIALS AND METHODS: A total of nine human BTC cell lines were used for evaluating anti-tumor effect of AZD6738 (ATR inhibitor) alone or combination with cytotoxic chemotherapeutic agents through MTT assay, colony-forming assays, cell cycle analyses, and comet assays. We established SNU478-mouse model for in vivo experiments to confirm our findings. …”
Publicado 2019
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939por Lechner, Anna, Kottner, Jan, Coleman, Susanne, Muir, Delia, Bagley, Heather, Beeckman, Dimitri, Chaboyer, Wendy, Cuddigan, Janet, Moore, Zena, Rutherford, Claudia, Schmitt, Jochen, Nixon, Jane, Balzer, Katrin“…TRIAL REGISTRATION: The OUTPUTs project is registered in the COMET database: (http://www.comet-initiative.org/studies/details/283). …”
Publicado 2019
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940por Asad, Farkhanda, Mubarik, Muhammad Samee, Ali, Tayyaba, Zahoor, Muhammad Kashif, Ashrad, Robina, Qamer, Samina“…Hence, maximum comet parameters (Tail length, Tail DNA and Olive Tail Moment) were observed in (in-organic Cr) by 0.3 mg/kg concentration. …”
Publicado 2019
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