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  1. 1041
    “…RESULTS: BrdUrd labelling close to DNA strand discontinuities (comet tails) detects the number of active replicons. …”
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    A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis
  2. 1042
    “…In contrast, all AgNPs tested caused an increase in overall DNA damage after 24 h assessed by the comet assay, suggesting independent mechanisms for cytotoxicity and DNA damage. …”
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    Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release
  3. 1043
    “…DNA damage was evaluated by immunofluorescence γH2AX staining and comet assay. Higher levels of intrinsic DNA damage were found in A2780 than in A2780/C30 cells. …”
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    Aberrant DNA Damage Response Pathways May Predict the Outcome of Platinum Chemotherapy in Ovarian Cancer
  4. 1044
    “…Further, significant decrease in GSH while increase in lipid peroxides (TBARS), H(2)O(2), DNA damages and comet length was induced with CCl(4) in hepatic tissues of rat. …”
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    Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl(4) induced hepatic toxicity in rat
  5. 1045
    “…Apoptotic mode of cell death was evaluated using standardized staining procedures including comet assay and annexin V/PI staining, Immuno-peroxidase assay. …”
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    Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma
  6. 1046
    “…Genotoxic and antigenotoxic effects were evaluated with a comet assay and micronuclei on binucleated cells. …”
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    Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador
  7. 1047
    “…In vitro, BFD and MBFD inhibited the growth of cultured H1975 and H292 NSCLC cells. The results of a comet assay revealed that BFD and MBFD increased DNA damage. …”
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    Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1
  8. 1048
    “…RESULTS: A dataset of 6 nanoforms of TiO(2) with more than 100 physicochemical properties each was collected. In vitro comet assay result was selected as the endpoint to read-across due to data availability. …”
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    Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques
  9. 1049
    “…The objective of this study was to determine the frequency of DNA damage through the comet assay and micronucleus (MN) test in two groups of children, under 10 yr of age living in rural Paraguay and in relation to pesticide exposure. …”
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    DNA damage induced by exposure to pesticides in children of rural areas in Paraguay
  10. 1050
    “…The relationship between outcomes chosen for comparative effectiveness research, outcomes used in decision-making in routine care, and outcome data recorded in electronic health records (EHR) is also poorly understood. The COMET Initiative (http://www.comet-initiative.org/. …”
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    Core outcome sets through the healthcare ecosystem: the case of type 2 diabetes mellitus
  11. 1051
    “…The work presented shows that not only can very low doses of alpha-particles produce DNA damage in normal HF19 fibroblast cells (detected using comet and micronuclei assays) in the irradiated cell population, but also results in an enhanced yield of DNA damage in the progeny of these cells out to 10 and even 20 population doublings. …”
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    Induction of Genomic Instability in a Primary Human Fibroblast Cell Line Following Low-Dose Alpha-Particle Exposure and the Potential Role of Exosomes
  12. 1052
    “…In contrast to MDMA, 25B-NBOMe showed subtle genotoxic effect observed in the comet assay. Our findings indicate that 25B-NBOMe shows hallucinogenic activity in the wide range of doses. …”
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    Neurochemical and Behavioral Effects of a New Hallucinogenic Compound 25B-NBOMe in Rats
  13. 1053
    “…On the other hand, different methods evaluating DNA integrity, such as Sperm Chromatin Dispersion (SCD) and Comet tests, need a previous complete DNA decondensation to properly assess DNA breaks. …”
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    Species-Specific Differences in Sperm Chromatin Decondensation Between Eutherian Mammals Underlie Distinct Lysis Requirements
  14. 1054
    “…Model input parameters were based on the SABR-COMET trial data as well as best available and most recent data provided in the published literature. …”
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    Cost-Effectiveness Analysis of Local Treatment in Oligometastatic Disease
  15. 1055
    “…TRIAL REGISTRATION NUMBER: http://www.comet-initiative.org/studies/details/1486.…”
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    Developing a core outcome set on traditional Chinese medicine (COS-TCM) for chronic heart failure (CHF): a study protocol
  16. 1056
    “…REGISTRATION DETAILS: Core Outcome Measures in Effectiveness Trials (COMET) Initiative database registration: http://www.comet-initiative.org/studies/details/1371…”
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    Study protocol to develop a core outcome set for thyroid dysfunction to bridge the unmet needs of patient-centred care
  17. 1057
    por Hanna, Demiana H., R. Saad, Gamal
    Publicado 2021
    “…Apoptosis induction in FA-SnO(2) NPs treated SKOV3 cells were investigated using Annexin V/PI, AO/EB and Comet assays and the possible mechanisms of the cytotoxic action were studied by Flow cytometry, qRT-PCR, Immunohistochemistry, and Western blotting analyses. …”
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    Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles
  18. 1058
    “…In genotoxicity assay using SCGE comet, DNA tail moment values in the groups treated with dextran- and LMWH-coated SPIO nanoparticles significantly increased. …”
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    Hepatic and renal cellular cytotoxic effects of heparin-coated superparamagnetic Iron oxide nanoparticles
  19. 1059
    “…The micronucleus test (MN) and the comet assay were used to assess the cytogenotoxic and anticytogenotoxic potential of VpLAE and n-BF (250, 500, and 1000 mg/kg) administered via gavage to Swiss Webster mice. …”
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    Phytochemical Composition and Protective Effect of Vernonanthura polyanthes Leaf against In Vivo Doxorubicin-Mediated Toxicity
  20. 1060
    “…There was a non-significant difference among preoperative, 6-months, and 12-months postoperative comet assay measurements. CONCLUSION: From previous findings, we can conclude that will-functioning MOP hip arthroplasty can induce increased ion levels and positively correlated increase in biochemical markers of genotoxicity (8-OHdG).…”
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    Psychiatric Disorders and Genotoxicity Following Primary Metal on Polyethylene Total Hip Arthroplasty and Their Correlation to Cobalt/Chromium Levels
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