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  1. 1361
    “…We found that AD patient cells indeed showed an altered DNA repair kinetics (comet assay). Real-time quantitative analysis of genes associated with DNA stress response also showed that FANCG and CDKN1A are upregulated in AD, while MTH1 is downregulated, compared with the control group. …”
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    Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes
  2. 1362
    “…The chromosomal aberrations, cytokinesis-block micronucleus (CBMN, the CBMN assay), and DNA double-strand breaks (DSBs, the comet assay) examined in this study are biomarkers for cytogenetic abnormalities. …”
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    Cytogenetic Abnormalities in Lymphocytes from Victims Exposed to Cobalt-60 Radiation
  3. 1363
    “…Ebselen and (PhSe)(2) were genotoxic (Comet Assay) only at 50 μM, and (PhTe)(2) at 5–50 μM. …”
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    Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride
  4. 1364
    “…NPs cytotoxicity was investigated by cell viability, membrane integrity, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) assays, and their genotoxicity by comet assay. Our results show that NPs surface passivation reduces the oxidative stress and alteration of iron homeostasis and, consequently, the overall toxicity, despite bare and passivated NPs show similar cell internalization efficiency. …”
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    Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering
  5. 1365
    “…DNA damage of single cell of nauplii was determined by comet assay. This study showed that as the concentration of AgNPs increased, the mortality rate, aggregation in gut region, apoptotic cells, and DNA damage increased in nauplii, whereas the percentage of hatching in Artemia cysts decreased. …”
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    Toxicity Effect of Silver Nanoparticles in Brine Shrimp Artemia
  6. 1366
    “…In support of this, DNA damage was triggered by Dovitinib as revealed by γ-H2AX and comet assays. The mitotic kinase CDK1 was found to be inactivated by phosphorylation in the presence of Dovitinib. …”
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    Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint
  7. 1367
    por Chung, Young-Shin, Lee, Michael
    Publicado 2013
    “…Erythritol induced a marginal increase of DNA damage at two high doses by 24 hr of exposure in a comet assay using L5178Y tk(+/−) cells. Additionally, in vivo micronucleus tests clearly demonstrated that oral administration of erythritol did not induce micronuclei formation of the bone marrow cells of male ICR mice. …”
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    Genotoxicity Assessment of Erythritol by Using Short-term Assay
  8. 1368
    por Hong, Chang-Eui, Lyu, Su-Yun
    Publicado 2013
    “…Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum.…”
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    Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai
  9. 1369
    “…Genotoxicity (as determined by comet assay) and mutagenicicity were used as end-points of toxicity. …”
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    Differential genotoxicity of diphenyl diselenide (PhSe)(2) and diphenyl ditelluride (PhTe)(2)
  10. 1370
    “…UVB exposure resulted in damage to cellular DNA, as demonstrated in a comet assay; pre-treatment of cells with CGA prior to UVB irradiation prevented DNA damage and increased cell viability. …”
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    The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes
  11. 1371
    “…Meanwhile, urinary 8-hydroxy-2'-deoxyguanosine excretion was lower significantly in the rape group and the ratio of comet tail length to total length of blood mononuclear cells was decreased significantly in 3 vegetables treated groups. …”
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    No correlation is found for vegetables between antioxidant capacity and potential benefits in improving antioxidant function in aged rats
  12. 1372
    “…Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological changes. …”
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    Effect of saffron (Crocus sativus L.) on sodium valporate induced cytogenetic and testicular alterations in albino rats
  13. 1373
    “…Specifically, we simulated conditions after a potential strike in the subpolar regions of Titan that exhibit vast methane-ethane lakes. If the asteroid or comet was of sufficient size, it would also puncture the icy crust and bring up some of the subsurface liquid ammonia-water mixture. …”
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    Simulations of Prebiotic Chemistry under Post-Impact Conditions on Titan
  14. 1374
    “…We assessed genome instability by means of the comet assay and the cytokinesis-block micronucleus technique in crack cocaine users at the time of admission to a rehabilitation clinic and at two times after the beginning of withdrawal. …”
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    Genomic Instability in Human Lymphocytes from Male Users of Crack Cocaine
  15. 1375
    por Hestermann, Andrea, Gräf, Ralph
    Publicado 2004
    “…RESULTS: Here we show that overexpression of an N-terminal fragment of DdCP224, the Dictyostelium XMAP215 homologue, caused a collapse of the radial microtubule cytoskeleton, whereby microtubules lost contact with the cell cortex and were dragged behind like a comet tail of an unusually motile centrosome. This phenotype was indistinguishable from mutants overexpressing fragments of the dynein heavy chain or intermediate chain. …”
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    The XMAP215-family protein DdCP224 is required for cortical interactions of microtubules
  16. 1376
    por Prasad, Ram, Katiyar, Santosh K.
    Publicado 2015
    “…These effects of GTPs were associated with a significant inhibition of histone deacetylase (HDAC) activity, reduction in the levels of class I HDAC proteins, enhancement of histone acetyltransferase (HAT) activity and induction of DNA damage, as detected by Comet assay, in melanoma cells. GTPs-induced decrease in the levels of class I HDAC proteins is mediated through proteasomal degradation. …”
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    Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage
  17. 1377
    “…DNA damage was analyzed as strand breaks by the comet assay and levels of formamidopyrimidine (FPG-) and human 8-oxoguanine DNA glycosylase 1 (hOGG1)-sensitive sites There was an association between age and levels of FPG-sensitive sites for women, but not for men. …”
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    Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
  18. 1378
    “…Furthermore, MFKF-AP1β (25–100 μg/ml) significantly induced single-stranded DNA breakage in A549 cells, as shown by comet assay. Taken together, our results demonstrate that MFKF-AP1β has strong anti-tumor effects mediated through induction of apoptosis. …”
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    Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line
  19. 1379
    “…Antigenotoxic potentials of extracts were assessed on human peripheral white blood cells with basidiocarp and mycelium extracts of the species. The alkaline comet test was used for detection of DNA strand breaks and alkali-labile sites, as well as the extent of DNA migration. …”
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    Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells
  20. 1380
    “…DNA fragments in the acetaminophen-injected group were also significantly increased (P < 0.05). The comet assay revealed increased detaching tail length and DNA concentration during the hepatic toxicity in the acetaminophen group. …”
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    Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats
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