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  1. 8761
    “…Interestingly, in all breast tumor tissues analyzed, variations in the Kid/KIF22 mRNA levels mirrored those seen with SIAH-1 mRNAs. This concerted variation of SIAH-1 and Kid/KIF22 messengers suggests the existence of an additional level of control than the previously described protein-protein interaction and protein stability regulation. …”
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    Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes
  2. 8762
    “…The MRIs identified in FL cells also correlated well with transcriptomic data and ChIP-on-Chip analyses of genome-wide histone modifications such as tri-methyl-H3K27, and tri-methyl-H3K4, indicating a concerted epigenetic alteration in FL cells. CONCLUSIONS/SIGNIFICANCE: This study is the first to provide a large scale and comprehensive analysis of the DNA methylation sequence composition and distribution in the FL epigenome. …”
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    Genome-Wide DNA Methylation Maps in Follicular Lymphoma Cells Determined by Methylation-Enriched Bisulfite Sequencing
  3. 8763
    “…Overall, the present data provide evidence for molecular mechanisms involving the concerted actions of SUD-M and SUD-C, which result in specific RNA binding that might be unique to the SUD and, thus, to the SARS coronavirus.…”
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    SARS Coronavirus Unique Domain: Three-Domain Molecular Architecture in Solution and RNA Binding
  4. 8764
    “…BACKGROUND: To understand biological processes and diseases, it is crucial to unravel the concerted interplay of transcription factors (TFs), microRNAs (miRNAs) and their targets within regulatory networks and fundamental sub-networks. …”
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    MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model
  5. 8765
    “…Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that these chemokines could play a pathogenic role in heart failure (HF). …”
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    The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure
  6. 8766
    “…The reduction in claudin-2 protein expression may be partly responsible for the reduced Ca(2+) reabsorption in this segment. The concerted upregulation of more distal Ca(2+)-transporting molecules may be a physiological response to curtail the loss of Ca(2+), although the magnitude of compensation does not seem adequate to bring the urinary Ca(2+) excretion down to that of the normal-diet group.…”
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    Effects of a high-sodium diet on renal tubule Ca(2+) transporter and claudin expression in Wistar-Kyoto rats
  7. 8767
    “…Structure-based chemical-shift predictions indicated that the microsecond to millisecond dynamics in the 80′s loop probably arose from a concerted main chain (ψ(88) and ϕ(89)) torsion angle transition. …”
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    Structural basis of conformational transitions in the active site and 80′s loop in the FK506-binding protein FKBP12
  8. 8768
    “…CONCLUSIONS: The results of this survey indicate that medicine counterfeiting is not limited to essential medicines in Cambodia: newer-generation medicines are also targeted. Concerted efforts by both domestic and foreign manufacturers, wholesalers, retailers, and regulatory authorities should help improve the quality of medicines.…”
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    A cross-sectional investigation of the quality of selected medicines in Cambodia in 2010
  9. 8769
    por Smith, Ben J, Ali, Suha, Quach, Henry
    Publicado 2014
    “…In Australia many people do not yet hold beliefs and knowledge that support this, which highlights the need for concerted awareness raising that dementia is not an inevitable aspect of ageing, and for education about the role of vascular health in dementia risk reduction.…”
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    Public knowledge and beliefs about dementia risk reduction: a national survey of Australians
  10. 8770
    “…To determine the total concerted genetic contribution of these ncRNAs to γHV acute infection and pathogenesis, we generated and characterized a recombinant γHV68 strain devoid of all eight TMERs. …”
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    Gammaherpesvirus Small Noncoding RNAs Are Bifunctional Elements That Regulate Infection and Contribute to Virulence In Vivo
  11. 8771
    “…Indeed, while PFV and MLV integration reactions are favored into dense and stable nucleosomes, HIV-1 and ASV concerted integration reactions are preferred into poorly dense chromatin regions of our nucleosomal acceptor templates. …”
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    Intasome architecture and chromatin density modulate retroviral integration into nucleosome
  12. 8772
    “…Taken together, our findings support a role for MK3 in control of proliferation and replicative life-span, in part through concerted action with BMI1, and suggest that the effect of MK3 modulation or mutation on M/SAPK signaling and, ultimately, proliferation, is cell context-dependent.…”
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    MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points
  13. 8773
    “…CONCLUSIONS: We show the concerted actions of DNMT enzymes in the establishment and maintenance of methylation patterns. …”
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    Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
  14. 8774
    “…Adeno-associated viral vector-enforced re-expression of the CB(1) receptor in the dorsolateral striatum of R6/2 mice allowed the re-expression of BDNF and the concerted rescue of the neuropathological deficits in these animals. …”
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    The CB(1) cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway
  15. 8775
    “…CONCLUSIONS: During the study period, we observed a dramatic increase in the incidence of C-R Kp BSI in our hospital. More concerted infection-control efforts are needed to contain this alarming C-R Kp diffusion.…”
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    Trends in the annual incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy
  16. 8776
    “…These data highlights the needs for more concerted interventions targeting both prescribers and public. …”
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    Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia
  17. 8777
    “…BACKGROUND: Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. …”
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    Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways
  18. 8778
    “…Conclusion The current “epidemic” of thyroid cancer in South Korea is due to an increase in the detection of small tumours, most likely as a result of overdetection. Concerted efforts are needed at a national level to reduce unnecessary thyroid ultrasound examinations in the asymptomatic general population.…”
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    Association between screening and the thyroid cancer “epidemic” in South Korea: evidence from a nationwide study
  19. 8779
    “…With the growing interest of industry in applying Systems Biology approaches in their fields, a concerted action between academia and industry is needed to build this expertise. …”
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    Strategies for structuring interdisciplinary education in Systems Biology: an European perspective
  20. 8780
    “…Perception towards the condom was a significant factor that influenced the confidence to use a female condom (F = 9.896; p < 0.000). CONCLUSIONS: Concerted efforts are advocated to improve the low perception exhibited towards the use of female condoms and the low perceived confidence to its utilization. …”
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    Perceived confidence to use female condoms among students in Tertiary Institutions of a Metropolitan City, Southwestern, Nigeria
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