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3821por Fertig, Tudor Emanuel, Chitoiu, Leona, Terinte‐Balcan, George, Peteu, Victor‐Eduard, Marta, Daciana, Gherghiceanu, Mihaela“…Perhaps, there was no time in recent history where cryo‐EM was more needed, as SARS‐CoV‐2 has spread around the globe, causing millions of deaths and almost unquantifiable economic devastation. In this concise review, we aim to mark the most important contributions of cryo‐EM to understanding the structure and function of SARS‐CoV‐2 proteins, from surface spikes to the virus core and from virus‐receptor interactions to antibody binding.…”
Publicado 2021
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3822“…As the ultimate goal is to retrieve unbiased information from biased ensembles, we also discuss benefits and limitations of common reweighting schemes. In addition to concisely summarizing critical assumptions and implications, we highlight the general application opportunities as well as uncertainties of global enhanced sampling.…”
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3823por Sager, Omer, Dincoglan, Ferrat, Demiral, Selcuk, Gamsiz, Hakan, Uysal, Bora, Ozcan, Fatih, Colak, Onurhan, Gumustepe, Esra, Elcim, Yelda, Gundem, Esin, Dirican, Bahar, Beyzadeoglu, Murat“…Within this context, we herein provide a concise overview of current evidence and future prospects regarding the optimal timing of thoracic irradiation for LS-SCLC in light of the literature.…”
Publicado 2022
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3824por Burke, Ashleigh J., Birmingham, William R., Zhuo, Ying, Thorpe, Thomas W., Zucoloto da Costa, Bruna, Crawshaw, Rebecca, Rowles, Ian, Finnigan, James D., Young, Carl, Holgate, Gregory M., Muldowney, Mark P., Charnock, Simon J., Lovelock, Sarah L., Turner, Nicholas J., Green, Anthony P.“…[Image: see text] The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally available treatment for SARS-CoV-2. …”
Publicado 2022
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3825“…The following transformations like regio- and stereoselective aldol condensation, Wittig olefination have been employed as the key steps, resulting in a concise total synthesis of (1S,2S,4S)-β-elemene. Our accomplishment will allow further biological investigations of this natural product and open opportunities for developing a new potentially promising antitumor drug.…”
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3826por Auer, Matthew R.“…Crafting communications that are concise and factual, compassionate, that instill confidence, and that evince organizational competence are important facets of crisis communications. …”
Publicado 2021
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3827“…In this article, we concisely and critically review the role of NAD(+) in mechanisms promoting genome maintenance. …”
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3828por Ehudin, Melanie A., Golla, Upendarrao, Trivedi, Devnah, Potlakayala, Shobha D., Rudrabhatla, Sairam V., Desai, Dhimant, Dovat, Sinisa, Claxton, David, Sharma, Arati“…In addition, selenium levels in patients have been correlated with various cancers and have served as a diagnostic marker to track the efficiency of treatments or to determine whether these selenium levels cause or are a result of the disease. This concise review presents a survey of the selenium-based literature, with a focus on hematological malignancies, to demonstrate the significant impact of selenium in different cancers. …”
Publicado 2022
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3829por Watanabe, Ayako, Hama, Kotaro, Watanabe, Kohei, Fujiwara, Yuko, Yokoyama, Kazuaki, Murata, Shigeo, Takita, Ryo“…We describe a concise and reliable protocol for the precisely controlled tetradeuteration of straight‐chain fatty acids (FAs) at the α‐ and β‐positions that is generally applicable to a variety of FAs, including trans‐FAs, polyunsaturated FAs (PUFAs), and their oxidized derivatives. …”
Publicado 2022
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3830por Yenyuwadee, Sasitorn, Sanchez-Trincado Lopez, Jose Luis, Shah, Rushil, Rosato, Pamela C., Boussiotis, Vassiliki A.“…As T(RM) form the most abundant T memory cell population in nonlymphoid tissues, they are attractive targets for therapeutic exploitation. Here, we provide a concise review of the development and physiological role of CD8(+) T(RM), their involvement in diseases, and their potential therapeutic exploitation.…”
Publicado 2022
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3831“…The structures of the 3-cyanopyrroles were confirmed by single-crystal X-ray diffraction and NMR; this work provides a general and practical entry to pyrrole scaffolds suitably decorated for the synthesis of various bioactive pyrroles in a concise manner.…”
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3832por Li, Muyang, Singh, Ragini, Wang, Yiran, Marques, Carlos, Zhang, Bingyuan, Kumar, Santosh“…This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. …”
Publicado 2022
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3833por Aurangabadkar, Gaurang M, Aurangabadkar, Milind Y, Choudhary, Sumer S, Ali, Saood N, Khan, Shafee M, Jadhav, Ulhas S“…This review article provides a concise overview of the four most common rheumatological conditions associated with pulmonary involvement: systemic lupus erythematosus (SLE), dermatomyositis/polymyositis, rheumatoid arthritis (RA), and systemic sclerosis (SSc). …”
Publicado 2022
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3834por Kalinski, Jarmo-Charles J., Polyzois, Alexandros, Waterworth, Samantha C., Siwe Noundou, Xavier, Dorrington, Rosemary A.“…Herein, we provided a concise summary of key findings and recent developments pertaining to their structural diversity, distribution, biogenesis, and their potential as chemical probes for drug development, including a discussion of promising synthetic analogs.…”
Publicado 2022
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3835“…The review provides a concise resource for researchers wishing to use machine learning methods to rapidly develop effective adsorbent materials with a positive impact on the environment.…”
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3836por Garbo, Sabrina, Di Giacomo, Silvia, Łażewska, Dorota, Honkisz-Orzechowska, Ewelina, Di Sotto, Antonella, Fioravanti, Rossella, Zwergel, Clemens, Battistelli, Cecilia“…The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents.…”
Publicado 2022
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3837“…It is well-known that it can form fibrils at the site of injection, leading to inflammation and immune response, in addition to other side effects. In this concise review, we analyze the current knowledge on insulin fibrillation, with a focus on the development of peptide-based inhibitors, which are promising candidates for their biocompatibility but still pose challenges to their effective use in therapy.…”
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3838“…This review article concisely presents the currently available evidence on the commonly used isolated supplements (anti-oxidative substances, amino acids, essential fatty acids) and difficulties related to their clinical use. …”
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3839Publicado 2023“…Using standardized terminology recommended by BI-RADS, radiologists can concisely and reproducibly communicate breast imaging results to clinicians. …”
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3840“…Microlectures comprise short audio or video presentations designed to provide a concise explanation of key concepts or topics. PURPOSE: The study aimed to develop a microlecture module for a nursing course in medication administration and test whether it could improve learning. …”
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