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  1. 570221
    por Gomes, Marília B, Cobas, Roberta A, Matheus, Alessandra S, Tannus, Lucianne R, Negrato, Carlos Antonio, Rodacki, Melanie, Braga, Neuza, Cordeiro, Marilena M, Luescher, Jorge L, Berardo, Renata S, Nery, Marcia, Arruda-Marques, Maria do Carmo, Calliari, Luiz E, Noronha, Renata M, Manna, Thais D, Zajdenverg, Lenita, Salvodelli, Roberta, Penha, Fernanda G, Foss, Milton C, Foss-Freitas, Maria C, Pires, Antonio C, Robles, Fernando C, Guedes, MariadeFátimaS, Dib, Sergio A, Dualib, Patricia, Silva, Saulo C, Sepulvida, Janice, Almeida, Henriqueta G, Sampaio, Emerson, Rea, Rosangela, Faria, Ana Cristina R, Tschiedel, Balduino, Lavigne, Suzana, Cardozo, Gustavo A, Azevedo, Mirela J, Canani, Luis Henrique, Zucatti, Alessandra T, Coral, Marisa Helena C, Pereira, Daniela Aline, Araujo, Luiz Antonio, Tolentino, Monica, Pedrosa, Hermelinda C, Prado, Flaviane A, Rassi, Nelson, Araujo, Leticia B, Fonseca, Reine Marie C, Guedes, Alexis D, Matos, Odelissa S, Faria, Manuel, Azulay, Rossana, Forti, Adriana C, Façanha, Cristina, Montenegro, Ana Paula, Montenegro, Renan, Melo, Naira H, Rezende, Karla F, Ramos, Alberto, Felicio, João Sooares, Santos, Flavia M, Jezini, Deborah L, Cordeiro, Marilena M
    Publicado 2012
    “…METHODS: This was a cross-sectional, multicenter study conducted from December 2008 to December 2010 in 28 secondary and tertiary care public clinics in 20 Brazilian cities in north/northeast, mid-west, southeast and south regions. …”
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  2. 570222
  3. 570223
    por Tardif, Jean-Claude, Ballantyne, Christie M., Barter, Philip, Dasseux, Jean-Louis, Fayad, Zahi A., Guertin, Marie-Claude, Kastelein, John J. P., Keyserling, Constance, Klepp, Heather, Koenig, Wolfgang, L'Allier, Philippe L., Lespérance, Jacques, Lüscher, Thomas F., Paolini, John F., Tawakol, Ahmed, Waters, David D., Pfeffer, M., Brown, V., Rouleau, J., Watkins, P., Wei, L.J., Gosselin, G., Chayer, C., Lanthier, S., Pelletier, G.B., Racine, N., Agarwal, H., Brilakis, E., Cannon, L., Carrié, D., Corbelli, J., Coste, P., de Winter, R., Diaz, A., Eisenberg, S., Ennis, B., Fajadet, J., Fam, N., Fortuin, D., Gessler, C., Grines, C., Guerra, D., Gum, H., Haldis, T., Heestermans, T., Herrman, J.P., Huynh, T., Kedhi, E., Koren, M., Kouz, S., Krolick, M., Kumkumian, G., Lavi, S., Li, R.J., Masud, ARZ, McAlhany, C., McGrew, F.A., O'Shaughnessy, C., Oude Ophuis, A.J.M., Parr, K., Penny, W., Pesant, Y., Post, H., Robinson, S., Rodes-Cabau, J., Roy, A., Schulman, S., Spence, F., Stouffer, G., Stys, T., Sussex, B., Tahirkheli, N., Tardif, J-C., Grégoire, J., ten Berg, J., van Boven, A.J., von Birgelen, C., Weinstein, D.
    Publicado 2014
    “…DESIGN AND SETTING: A prospective, double-blinded, randomized trial was conducted at 51 centres in the USA, the Netherlands, Canada, and France. …”
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  4. 570224
    “…A rapid, iterative prototyping process with 15 health professionals from nonparticipating centers will allow us to identify and resolve usability issues prior to finalizing the definitive version for the interrupted time series. Second, we will conduct an interrupted time series to measure the impact of our combined intervention on the quality of care in four trauma centers that will be selected—one level I, one level II, and two level III centers. …”
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  5. 570225
  6. 570226
  7. 570227
  8. 570228
    por Guo, Yan, Warren Andersen, Shaneda, Shu, Xiao-Ou, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Garcia-Closas, Montserrat, Milne, Roger L., Schmidt, Marjanka K., Chang-Claude, Jenny, Dunning, Allison, Bojesen, Stig E., Ahsan, Habibul, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bogdanova, Natalia V., Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brand, Judith, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Casey, Graham, Chenevix-Trench, Georgia, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dumont, Martine, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Gammon, Marilie, Giles, Graham G., Guénel, Pascal, Haiman, Christopher A., Hamann, Ute, Hooning, Maartje J., Hopper, John L., Jakubowska, Anna, Jasmine, Farzana, Jenkins, Mark, John, Esther M., Johnson, Nichola, Jones, Michael E., Kabisch, Maria, Kibriya, Muhammad, Knight, Julia A., Koppert, Linetta B., Kosma, Veli-Matti, Kristensen, Vessela, Le Marchand, Loic, Lee, Eunjung, Li, Jingmei, Lindblom, Annika, Luben, Robert, Lubinski, Jan, Malone, Kathi E., Mannermaa, Arto, Margolin, Sara, Marme, Frederik, McLean, Catriona, Meijers-Heijboer, Hanne, Meindl, Alfons, Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Olson, Janet E., Perez, Jose I. A., Perkins, Barbara, Peterlongo, Paolo, Phillips, Kelly-Anne, Pylkäs, Katri, Rudolph, Anja, Santella, Regina, Sawyer, Elinor J., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shrubsole, Martha J., Southey, Melissa C., Swerdlow, Anthony J., Toland, Amanda E., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Ursin, Giske, Van Der Luijt, Rob B., Verhoef, Senno, Whittemore, Alice S., Winqvist, Robert, Zhao, Hui, Zhao, Shilin, Hall, Per, Simard, Jacques, Kraft, Peter, Pharoah, Paul, Hunter, David, Easton, Douglas F., Zheng, Wei
    Publicado 2016
    “…Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively. …”
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  9. 570229
  10. 570230
  11. 570231
  12. 570232
    por Nishida, Osamu, Ogura, Hiroshi, Egi, Moritoki, Fujishima, Seitaro, Hayashi, Yoshiro, Iba, Toshiaki, Imaizumi, Hitoshi, Inoue, Shigeaki, Kakihana, Yasuyuki, Kotani, Joji, Kushimoto, Shigeki, Masuda, Yoshiki, Matsuda, Naoyuki, Matsushima, Asako, Nakada, Taka-aki, Nakagawa, Satoshi, Nunomiya, Shin, Sadahiro, Tomohito, Shime, Nobuaki, Yatabe, Tomoaki, Hara, Yoshitaka, Hayashida, Kei, Kondo, Yutaka, Sumi, Yuka, Yasuda, Hideto, Aoyama, Kazuyoshi, Azuhata, Takeo, Doi, Kent, Doi, Matsuyuki, Fujimura, Naoyuki, Fuke, Ryota, Fukuda, Tatsuma, Goto, Koji, Hasegawa, Ryuichi, Hashimoto, Satoru, Hatakeyama, Junji, Hayakawa, Mineji, Hifumi, Toru, Higashibeppu, Naoki, Hirai, Katsuki, Hirose, Tomoya, Ide, Kentaro, Kaizuka, Yasuo, Kan’o, Tomomichi, Kawasaki, Tatsuya, Kuroda, Hiromitsu, Matsuda, Akihisa, Matsumoto, Shotaro, Nagae, Masaharu, Onodera, Mutsuo, Ohnuma, Tetsu, Oshima, Kiyohiro, Saito, Nobuyuki, Sakamoto, So, Sakuraya, Masaaki, Sasano, Mikio, Sato, Norio, Sawamura, Atsushi, Shimizu, Kentaro, Shirai, Kunihiro, Takei, Tetsuhiro, Takeuchi, Muneyuki, Takimoto, Kohei, Taniguchi, Takumi, Tatsumi, Hiroomi, Tsuruta, Ryosuke, Yama, Naoya, Yamakawa, Kazuma, Yamashita, Chizuru, Yamashita, Kazuto, Yoshida, Takeshi, Tanaka, Hiroshi, Oda, Shigeto
    Publicado 2018
    “…The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. …”
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  13. 570233
  14. 570234
  15. 570235
    “…In the present study, we characterize the null genotypes of GSTM1 and GSTT1 in order to investigate the association between them and the risk of developing essential hypertension. METHODS: We conducted a case-control study in Burkina Faso, including 245 subjects with essential hypertension as case and 269 control subjects with normal blood pressure. …”
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  16. 570236
    por Knight, Stephen R, Ho, Antonia, Pius, Riinu, Buchan, Iain, Carson, Gail, Drake, Thomas M, Dunning, Jake, Fairfield, Cameron J, Gamble, Carrol, Green, Christopher A, Gupta, Rishi, Halpin, Sophie, Hardwick, Hayley E, Holden, Karl A, Horby, Peter W, Jackson, Clare, Mclean, Kenneth A, Merson, Laura, Nguyen-Van-Tam, Jonathan S, Norman, Lisa, Noursadeghi, Mahdad, Olliaro, Piero L, Pritchard, Mark G, Russell, Clark D, Shaw, Catherine A, Sheikh, Aziz, Solomon, Tom, Sudlow, Cathie, Swann, Olivia V, Turtle, Lance CW, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G, Docherty, Annemarie B, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Openshaw, Peter JM, Carson, Gail, Alex, Beatrice, Bach, Benjamin, Barclay, Wendy S, Bogaert, Debby, Chand, Meera, Cooke, Graham S, Docherty, Annemarie B, Dunning, Jake, da Silva Filipe, Ana, Fletcher, Tom, Green, Christopher A, Harrison, Ewen M, Hiscox, Julian A, Ho, Antonia Ying Wai, Horby, Peter W, Ijaz, Samreen, Khoo, Saye, Klenerman, Paul, Law, Andrew, Lim, Wei Shen, Mentzer, Alexander J, Merson, Laura, Meynert, Alison M, Noursadeghi, Mahdad, Moore, Shona C, Palmarini, Massimo, Paxton, William A, Pollakis, Georgios, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Russell, Clark D, Sancho-Shimizu, Vanessa, Scott, Janet T, Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Summers, Charlotte, Tedder, Richard S, Thomson, Emma C, Thwaites, Ryan S, Turtle, Lance CW, Zambon, Maria, Hardwick, Hayley, Donohue, Chloe, Ewins, Jane, Oosthuyzen, Wilna, Griffiths, Fiona, Norman, Lisa, Pius, Riinu, Drake, Tom M, Fairfield, Cameron J, Knight, Stephen, Mclean, Kenneth A, Murphy, Derek, Shaw, Catherine A, Dalton, Jo, Girvan, Michelle, Saviciute, Egle, Roberts, Stephanie, Harrison, Janet, Marsh, Laura, Connor, Marie, Halpin, Sophie, Jackson, Clare, Gamble, Carrol, Leeming, Gary, Law, Andrew, Hendry, Ross, Scott-Brown, James, Greenhalf, William, Shaw, Victoria, McDonald, Sarah, Ahmed, Katie A, Armstrong, Jane A, Ashworth, Milton, Asiimwe, Innocent G, Bakshi, Siddharth, Barlow, Samantha L, Booth, Laura, Brennan, Benjamin, Bullock, Katie, Catterall, Benjamin WA, Clark, Jordan J, Clarke, Emily A, Cole, Sarah, Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Dunn, Chris, Dyer, Philip, Elliott, Angela, Evans, Anthony, Fisher, Lewis WS, Foster, Terry, Garcia-Dorival, Isabel, Greenhalf, Willliam, Gunning, Philip, Hartley, Catherine, Ho, Antonia, Jensen, Rebecca L, Jones, Christopher B, Jones, Trevor R, Khandaker, Shadia, King, Katharine, Kiy, Robyn T, Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, L, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A, Mancini, Maria, McDonald, Sarah, McEvoy, Laurence, McLauchlan, John, Metelmann, Soeren, Miah, Nahida S, Middleton, Joanna, Mitchell, Joyce, Moore, Shona C, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P Matthew, Sales, Debby, Shaw, Victoria E, Shears, Rebecca K, Small, Benjamin, Subramaniam, Krishanthi S, Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J Eunice, Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Alegria, Ana, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nicholas, Bassford, Christopher, Baxter, David, Beadsworth, Michael, Bernatoniene, Jolanta, Berridge, John, Best, Nicola, Bothma, Pieter, Brealey, David, Brittain-Long, Robin, Bulteel, Naomi, Burden, Tom, Burtenshaw, Andrew, Caruth, Vikki, Chadwick, David, Chambler, Duncan, Chee, Nigel, Child, Jenny, Chukkambotla, Srikanth, Clark, Tom, Collini, Paul, Cosgrove, Catherine, Cupitt, Jason, Cutino-Moguel, Maria-Teresa, Dark, Paul, Dawson, Chris, Dervisevic, Samir, Donnison, Phil, Douthwaite, Sam, DuRand, Ingrid, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Eziefula, Chi, Fegan, Chrisopher, Finn, Adam, Fullerton, Duncan, Garg, Sanjeev, Garg, Sanjeev, Garg, Atul, Godden, Jo, Goldsmith, Arthur, Graham, Clive, Hardy, Elaine, Hartshorn, Stuart, Harvey, Daniel, Havalda, Peter, Hawcutt, Daniel B, Hobrok, Maria, Hodgson, Luke, Holme, Anita, Hormis, Anil, Jacobs, Michael, Jain, Susan, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, Limb, James, Linnett, Vanessa, Little, Jeff, MacMahon, Michael, MacNaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, McCullough, Katherine, McEwen, Ruth, Meda, Manjula, Mills, Gary, Minton, Jane, Mirfenderesky, Mariyam, Mohandas, Kavya, Mok, Quen, Moon, James, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagel, Megan, Nagarajan, Thapas, Nelson, Mark, Otahal, Igor, Pais, Mark, Panchatsharam, Selva, Paraiso, Hassan, Patel, Brij, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Pooni, Jagtur Singh, Post, Frank, Price, David, Prout, Rachel, Rae, Nikolas, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shah, Aarti, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tamas, Tatham, Kate, Thomas, Jo, Thompson, Chris, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Ustianowski, Andrew, Vallotton, Nick, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Wilson, Sarah, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wooton, Daniel G, Workman, Andrew, Yates, Bryan, Young, Peter
    Publicado 2020
    “…Model training was performed on a cohort of patients recruited between 6 February and 20 May 2020, with validation conducted on a second cohort of patients recruited after model development between 21 May and 29 June 2020. …”
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  17. 570237
    por Cao, Bin, Wang, Yeming, Wen, Danning, Liu, Wen, Wang, Jingli, Fan, Guohui, Ruan, Lianguo, Song, Bin, Cai, Yanping, Wei, Ming, Li, Xingwang, Xia, Jiaan, Chen, Nanshan, Xiang, Jie, Yu, Ting, Bai, Tao, Xie, Xuelei, Zhang, Li, Li, Caihong, Yuan, Ye, Chen, Hua, Li, Huadong, Huang, Hanping, Tu, Shengjing, Gong, Fengyun, Liu, Ying, Wei, Yuan, Dong, Chongya, Zhou, Fei, Gu, Xiaoying, Xu, Jiuyang, Liu, Zhibo, Zhang, Yi, Li, Hui, Shang, Lianhan, Wang, Ke, Li, Kunxia, Zhou, Xia, Dong, Xuan, Qu, Zhaohui, Lu, Sixia, Hu, Xujuan, Ruan, Shunan, Luo, Shanshan, Wu, Jing, Peng, Lu, Cheng, Fang, Pan, Lihong, Zou, Jun, Jia, Chunmin, Wang, Juan, Liu, Xia, Wang, Shuzhen, Wu, Xudong, Ge, Qin, He, Jing, Zhan, Haiyan, Qiu, Fang, Guo, Li, Huang, Chaolin, Jaki, Thomas, Hayden, Frederick G., Horby, Peter W., Zhang, Dingyu, Wang, Chen
    Publicado 2020
    “…BACKGROUND: No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. METHODS: We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao(2)) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao(2)) to the fraction of inspired oxygen (Fio(2)) of less than 300 mm Hg. …”
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  18. 570238
    por Murphy, Neil, Carreras-Torres, Robert, Song, Mingyang, Chan, Andrew T., Martin, Richard M., Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K., Banbury, Barbara, Bradbury, Kathryn E., Besevic, Jelena, Rinaldi, Sabina, Riboli, Elio, Cross, Amanda J., Travis, Ruth C., Agnoli, Claudia, Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Onland-Moret, N. Charlotte, Burnett-Hartman, Andrea, Campbell, Peter T., Casey, Graham, Castellví-Bel, Sergi, Chang-Claude, Jenny, Chirlaque, María-Dolores, de la Chapelle, Albert, English, Dallas, Figueiredo, Jane C., Gallinger, Steven J., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Keku, Temitope O., Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martín, Vicente, Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Ose, Jennifer, Perduca, Vittorio, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Ulrich, Cornelia M., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zheng, Wei, Peters, Ulrike, Gunter, Marc J.
    Publicado 2020
    “…BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. …”
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  19. 570239
    “…METHODS: A multicenter, randomized, double-blind, parallel, positive control, phase III clinical trial was conducted at 28 locations in China. Patients with active ankylosing spondylitis were randomized in a 2:1 ratio to subcutaneously receive 40 mg of either HS016 or adalimumab every other week for 24 weeks. …”
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  20. 570240
    “…We aimed to determine whether insulin resistance mediates in part the association between race and breast cancer prognosis, and if insulin receptor (IR) and insulin-like growth factor receptor (IGF-1R) expression differs between tumors from Black and White women. METHODS: We conducted a cross-sectional, multi-center study across ten hospitals. …”
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