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  1. 570601
    “…However, the oncostatic function of melatonin on esophageal squamous cell carcinoma (ESCC) remains elusive. This study was conducted to investigate the potential effect and underlying molecular mechanism of melatonin as single anticancer agent against ESCC cells. …”
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    Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability
  2. 570602
    “…ChIP, EMSA and dual luciferase reporter assays were conducted to identify the binding sites of target genes. …”
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    Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer
  3. 570603
    por Farley, Shannon M., Wang, Chunhui, Bray, Rachel M., Low, Andrea Jane, Delgado, Stephen, Hoos, David, Kakishozi, Angela N., Harris, Tiffany G., Nyirenda, Rose, Wadonda, Nellie, Li, Michelle, Amuri, Mbaraka, Juma, James, Kancheya, Nzali, Pietersen, Ismela, Mutenda, Nicholus, Natanael, Salomo, Aoko, Appolonia, Ngugi, Evelyn W., Asiimwe, Fred, Lecher, Shirley, Ward, Jennifer, Chikwanda, Prisca, Mugurungi, Owen, Moyo, Brian, Nkurunziza, Peter, Aibo, Dorothy, Kabala, Andrew, Biraro, Sam, Ndagije, Felix, Musuka, Godfrey, Ndongmo, Clement, Shang, Judith, Dokubo, Emily K., Dimite, Laura E., McCullough‐Sanden, Rachel, Bissek, Anne‐Cecile, Getaneh, Yimam, Eshetu, Frehywot, Nkumbula, Tepa, Tenthani, Lyson, Kayigamba, Felix R., Kirungi, Wilford, Musinguzi, Joshua, Balachandra, Shirish, Kayirangwa, Eugenie, Ayite, Ayiyi, West, Christine A., Bodika, Stephane, Sleeman, Katrina, Patel, Hetal K., Brown, Kristin, Voetsch, Andrew C., El‐Sadr, Wafaa M., Justman, Jessica J.
    Publicado 2022
    “…METHODS: Using data from nationally representative Population‐based HIV Impact Assessments, conducted between 2015and 2019, participants from randomly selected households provided demographic and clinical information and whole blood specimens for HIV serology, VL and ARV testing. …”
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    Progress towards the UNAIDS 90‐90‐90 targets among persons aged 50 and older living with HIV in 13 African countries
  4. 570604
    “…Sources included eligible papers from 2 previous systematic reviews conducted by our team on telemental health; an updated search using the strategy from these reviews; a call for relevant evidence, including “gray literature,” to the public and key experts; and website searches of relevant voluntary and statutory organizations. …”
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    Synthesis of the Evidence on What Works for Whom in Telemental Health: Rapid Realist Review
  5. 570605
    “…Based on network pharmacology, molecular docking, and molecular dynamics (MD) simulations, we conducted a systematic review to evaluate the effects and neuroprotective mechanisms of ICS II on AIS. …”
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    Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis
  6. 570606
    “…Literature mining was conducted to identify all reported patients with defects in a gene with a high NIRD score; meta-analysis was performed on these patients to estimate the representation of NAHR deletions in recessive traits from contemporary human genomics studies. …”
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    Sequencing individual genomes with recurrent genomic disorder deletions: an approach to characterize genes for autosomal recessive rare disease traits
  7. 570607
    “…Both interventions were developed using a community-based participatory research (CBPR) approach. The study will be conducted in partnership with an urban Federally Qualified Health Center (FQHC) serving a low-income, Latino/a community, with target enrollment of 268 dyads consisting of an FQHC patient with T2D with high HbA1c and an SP. …”
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    Comparing the effectiveness of Family Support for Health Action (FAM-ACT) with traditional community health worker-led interventions to improve adult diabetes management and outcomes: study protocol for a randomized controlled trial
  8. 570608
    “…LX-2 cells treated with TGF-β (10 ng/ml) for 12 h were conducted for evaluating ADSC-EXO effect on activated hepatic stellate cells (HSCs). …”
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    ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis
  9. 570609
    “…Study implementation was reimagined to allow for completely virtual/online conduct to comply with local COVID-19 and institutional restrictions on in-person activities. …”
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    The BEACON study: an update to the protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario
  10. 570610
    “…METHODS: Using a stratified cluster sampling method in Xinjiang, China, 4833 middle school students aged 13–18 were selected., and tests for height and weight were conducted. Self-assessment questionnaires were completed for Dietary Behaviors, Physical Activity, and Sedentary Behaviors as well. …”
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    Compared with dietary behavior and physical activity risk, sedentary behavior risk is an important factor in overweight and obesity: evidence from a study of children and adolescents aged 13–18 years in Xinjiang, China
  11. 570611
    “…METHODS: In a large clustered randomized controlled trial (C-RCT; NCT02735382) conducted in 2016–2017, 11 primary care clinics in two healthcare systems implemented quitline eReferral, starting with 1 pilot clinic per system followed by 2 phases of implementation (an experimental phase in 5–6 test clinics per system and then a system-wide dissemination phase in both systems). …”
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    Electronic health record closed-loop referral (“eReferral”) to a state tobacco quitline: a retrospective case study of primary care implementation challenges and adaptations
  12. 570612
    “…We sought to determine whether making cesarean rate data more accessible and understandable increases the likelihood of pregnant people selecting low-cesarean rate hospitals. METHODS: We conducted a 1:1 randomized controlled trial in 2019–2021 among users of a fertility and pregnancy mobile application. …”
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    Impact of an educational program and decision tool on choice of maternity hospital: the delivery decisions randomized clinical trial
  13. 570613
    “…However, few contact studies have been conducted in Africa. METHODS: We analysed nationally representative cross-sectional survey data from 19 African Union Member States, collected by the Partnership for Evidence-based Responses to COVID-19 (PERC) via telephone interviews at two time points (August 2020 and February 2021). …”
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    Characterising social contacts under COVID-19 control measures in Africa
  14. 570614
    “…Assessments were completed during an orientation with all learners; then prior to the intervention (T1); at the end of the module (T2) and 3 months following the modules (T3) to assess retention. Focus groups were conducted to determine learners’ satisfaction with the different learning formats. …”
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    Impact of interactive multi-media learning for physicians in musculoskeletal education – a pilot study
  15. 570615
    “…The present study was conducted to investigate the impact of a probiotics, Enterococcus faecium NCIMB 11181 (E. faecium NCIMB 11181) on the intestinal mucosal immune responses, microbiome and barrier function in the presence or absence of Salmonella Typhimurium (S. …”
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    Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens
  16. 570616
    “…METHODS: The study was conducted in eyeworm endemic areas of Italy and France, where dogs (n = 125) were assigned into two groups consisting of a negative control group (G1; n = 62), in which animals were treated monthly with a control product (sarolaner; Simparica(®)), and a treatment group (G2; n = 63) in which animals were treated monthly with Simparica Trio (sarolaner/moxidectin/pyrantel) from day 0 to day 150. …”
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    Efficacy of a formulation of sarolaner/moxidectin/pyrantel (Simparica Trio(®)) for the prevention of Thelazia callipaeda canine eyeworm infection
  17. 570617
    “…A cross-sectional survey was conducted in 12 districts to evaluate the impact of the campaign 1–5 months after LLIN distribution. …”
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    LLIN Evaluation in Uganda Project (LLINEUP2)—Factors associated with coverage and use of long‑lasting insecticidal nets following the 2020–21 national mass distribution campaign: a cross-sectional survey of 12 districts
  18. 570618
    “…We aimed to explore the response to neoadjuvant chemotherapy (NAC) in HER2-low early BC according to the HER2 score (1 + or 2 + without amplification). METHODS: We conducted a retrospective study in two French comprehensive cancer centers. …”
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    HELENA: HER2-Low as a prEdictive factor of response to Neoadjuvant chemotherapy in eArly breast cancer
  19. 570619
    “…However, the role of mTORC1 downstream proteins, including ribosomal protein S6K (RP-S6K), eukaryotic initiation factor 4E-binding protein (EIF4EBP), eukaryotic initiation factor 4G (EIF-4G), eukaryotic initiation factor 4E (EIF-4E), and eukaryotic initiation factor 4A (EIF-4A), in regulating cataract development is still unknown. Herein, we conducted a mendelian randomization (MR) study to understand the function of mTORC1 signaling in the process of cataract development. …”
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    Association of mTORC1‑dependent circulating protein levels with cataract formation: a mendelian randomization study
  20. 570620
    “…The mean Hb difference and, where reported, the DO(2) difference before and after fluid administration were extracted. Meta-analyses were conducted to assess differences in Hb before and after rapid fluid administration in all subjects and across subgroups. …”
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    Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis
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