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572041por Sterne, Jonathan A. C., Diaz, Janet, Villar, Jesús, Murthy, Srinivas, Slutsky, Arthur S., Perner, Anders, Jüni, Peter, Angus, Derek C., Annane, Djillali, Azevedo, Luciano Cesar Pontes, Du, Bin, Dequin, Pierre-Francois, Gordon, Anthony C., Green, Cameron, Higgins, Julian P. T., Horby, Peter, Landray, Martin J., Lapadula, Giuseppe, Le Gouge, Amelie, Leclerc, Marie, Savović, Jelena, Tomazini, Bruno, Venkatesh, Balasubramanian, Webb, Steve, Marshall, John C.“…STATISTICAL ANALYSES: Trial investigators will provide data on the numbers of participants who did and did not experience each outcome according to intervention group, overall and in specified subgroups. We will conduct fixed-effect (primary analysis) and random-effects (Paule-Mandel estimate of heterogeneity and Hartung-Knapp adjustment) meta-analyses. …”
Publicado 2020
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572042por Watts, Rebecca E., Odedra, Anand, Marquart, Louise, Webb, Lachlan, Abd-Rahman, Azrin N., Cascales, Laura, Chalon, Stephan, Rebelo, Maria, Pava, Zuleima, Collins, Katharine A., Pasay, Cielo, Chen, Nanhua, Peatey, Christopher L., Möhrle, Jörg J., McCarthy, James S.“…METHODS AND FINDINGS: We conducted 2 sequential phase 1, single-centre, open-label clinical trials at Q-Pharm, Brisbane, Australia, using the induced blood-stage malaria (IBSM) model, whereby healthy participants are intravenously inoculated with blood-stage parasites. …”
Publicado 2020
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572043por Cree, Bruce A. C., Goldman, Myla D., Corboy, John R., Singer, Barry A., Fox, Edward J., Arnold, Douglas L., Ford, Corey, Weinstock-Guttman, Bianca, Bar-Or, Amit, Mientus, Susanne, Sienkiewicz, Daniel, Zhang, Ying, Karan, Rajesh, Tenenbaum, Nadia“…DESIGN, SETTING, AND PARTICIPANTS: The Multiple Sclerosis Study Evaluating Safety and Efficacy of Two Doses of Fingolimod Versus Copaxone (ASSESS) was a phase 3b multicenter randomized rater-blinded and dose-blinded 12-month clinical trial conducted between August 9, 2012, and April 30, 2018 (including the time required to recruit participants). …”
Publicado 2021
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572044por Naar, Sylvie, Robles, Gabriel, MacDonell, Karen Kolmodin, Dinaj-Koci, Veronica, Simpson, Kit N., Lam, Phebe, Parsons, Jeffrey T., Sizemore, K. Marie, Starks, Tyrel J.“…DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was conducted from November 1, 2014, to January 31, 2018, with 52 weeks of follow-up. …”
Publicado 2020
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572045por Anderson, Emma, Parslow, Roxanne, Hollingworth, William, Mills, Nicola, Beasant, Lucy, Gaunt, Daisy, Metcalfe, Chris, Kessler, David, Macleod, John, Pywell, Susan, Pitts, Kieren, Price, Simon, Stallard, Paul, Knoop, Hans, Van de Putte, Elise, Nijhof, Sanne, Bleijenberg, Gijs, Crawley, Esther“…Eligibility assessment and recruitment were conducted via remote methods (telephone and on the web), and participants were randomized (via a computer-automated system) to 1 of 2 web-based treatments. …”
Publicado 2020
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572046“…In phase 3, qualitative interviews related to user experiences were conducted with participants in the Reminder+COM-B Message intervention group. …”
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572047“…We also generated Bland-Altman plots and conducted equivalence tests. RESULTS: A total of 36 individuals participated (n=20 intact mobility and n=16 limited mobility; 19/36, 53% female) with a mean age of 71.4 (SD 4.7) years and BMI of 29.4 (SD 5.9) kg/m(2). …”
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572048por Wang, Lu, Di, Yujing, Guo, Tingting, Ming, Jeffrey E., Kong, Fangyuan, Yin, Huiqiu, Zhang, Linlin, Xie, Fang, Yang, Na, Ping, Chuan, Li, Yi, Hou, Jie“…METHODS: This was a randomized, single-center, open-label, three-sequence, three-period, two-treatment, crossover study with a washout period of 10 days conducted in healthy Chinese volunteers. Subjects were randomized to receive Co-Plavix(®) (test formulation- fixed-dose combination of 100 mg acetylsalicylic acid and 75 mg clopidogrel) once and reference formulations (coadministration of individual formulations of 100 mg acetylsalicylic acid and 75 mg clopidogrel) twice during the study period. …”
Publicado 2020
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572049“…METHODS: A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library until the end of April. …”
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572050por Iadarola, Suzannah, Pellecchia, Melanie, Stahmer, Aubyn, Lee, Hyon Soo, Hauptman, Lindsay, Hassrick, Elizabeth McGhee, Crabbe, Samantha, Vejnoska, Sarah, Morgan, Elizabeth, Nuske, Heather, Luelmo, Paul, Friedman, Chris, Kasari, Connie, Gulsrud, Amanda, Mandell, David, Smith, Tristram“…We also present on the results of a pilot of MTG, conducted in preparation for a randomized controlled trial. …”
Publicado 2020
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572051por Wu, Xuejiao, Huang, Jia, Yang, Zilin, Zhu, Ying, Zhang, Yongping, Wang, Jiancheng, Yao, Weiyan“…In addition, several miR-221-3p functional analyses were conducted, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Protein–protein interaction (PPI) network analyses, to examine gene interactions with miR-221-3p. …”
Publicado 2020
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572052por Kivimäki, Mika, Singh-Manoux, Archana, Batty, G. David, Sabia, Séverine, Sommerlad, Andrew, Floud, Sarah, Jokela, Markus, Vahtera, Jussi, Beydoun, May A., Suominen, Sakari B., Koskinen, Aki, Väänänen, Ari, Goldberg, Marcel, Zins, Marie, Alfredsson, Lars, Westerholm, Peter J. M., Knutsson, Anders, Nyberg, Solja T., Sipilä, Pyry N., Lindbohm, Joni V., Pentti, Jaana, Livingston, Gill, Ferrie, Jane E., Strandberg, Timo“…Dementia was examined during a mean follow-up of 14.4 years (range, 12.3-30.1). Data analysis was conducted from November 17, 2019, to May 23, 2020. …”
Publicado 2020
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572053por Fitzsimmons-Craft, Ellen E., Taylor, C. Barr, Graham, Andrea K., Sadeh-Sharvit, Shiri, Balantekin, Katherine N., Eichen, Dawn M., Monterubio, Grace E., Goel, Neha J., Flatt, Rachael E., Karam, Anna M., Firebaugh, Marie-Laure, Jacobi, Corinna, Jo, Booil, Trockel, Mickey T., Wilfley, Denise E.“…DESIGN, SETTING, AND PARTICIPANTS: This cluster randomized trial was conducted from 2014 to 2018 at 27 US universities. …”
Publicado 2020
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572054por Alem, Adugnaw Zeleke, Yeshaw, Yigizie, Kebede, Sewnet Adem, Liyew, Alemneh Mekuriaw, Tesema, Getayeneh Antehunegn, Agegnehu, Chilot Desta, Teshale, Achamyeleh Birhanu“…METHODS: A detailed analysis of the 2016 Ethiopian Demographic and Health Survey data was conducted. A total weighted sample of 11,646 reproductive-age married women were included in the analysis. …”
Publicado 2020
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572055por Antoniou, Panagiotis E, Arfaras, George, Pandria, Niki, Athanasiou, Alkinoos, Ntakakis, George, Babatsikos, Emmanouil, Nigdelis, Vasilis, Bamidis, Panagiotis“…METHODS: A wearable array of sensors recording HR, EDA, and EEG signals was deployed during 2 educational activities conducted by 11 participants of diverse educational level (undergraduate, postgraduate, and specialist neurosurgeon doctors). …”
Publicado 2020
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572056por McNulty, Kelly Lee, Elliott-Sale, Kirsty Jayne, Dolan, Eimear, Swinton, Paul Alan, Ansdell, Paul, Goodall, Stuart, Thomas, Kevin, Hicks, Kirsty Marie“…A more comprehensive analysis was then conducted, comparing exercise performance between all phases with direct and indirect pairwise effect sizes through a network meta-analysis. …”
Publicado 2020
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572057por Bharti, Praveen K., Rajvanshi, Harsh, Nisar, Sekh, Jayswar, Himanshu, Saha, Kalyan B., Shukla, Man Mohan, Mishra, Ashok K., Sharma, Ravendra K., Das, Aparup, Kaur, Harpreet, Wattal, Suman L., Lal, Altaf A.“…In addition to the active and passive surveillance for detection and treatment of febrile cases, the project conducted mass screening and treatment to clear the asymptomatic reservoirs of infection. …”
Publicado 2020
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572058por Yi, Hong, Zhang, Wei, Cui, Zhi-Ming, Cui, Sheng-Yu, Fan, Jian-Bo, Zhu, Xin-Hui, Liu, Wei“…Kyoto encyclopedia of genes and genomes (KEGG) pathway as well as gene ontology (GO) were further conducted through Metascape online tool. A cell counting kit-8 (CCK-8) assay was applied to discover the viability of chondrocytes (6, 12, 24, and 48 μM). …”
Publicado 2020
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572059por Fu, Weihui, Liu, Yan, Liu, Li, Hu, Huiliang, Cheng, Xiaobo, Liu, Ping, Song, Zhigang, Zha, Lijun, Bai, Shimeng, Xu, Tingting, Yuan, Songhua, Lu, Fengru, Shang, Zhiying, Zhao, Yihong, Wang, Jing, Zhao, Jun, Ding, Longfei, Chen, Jun, Zhang, Lin, Zhu, Tongyu, Zhang, Xiaoyan, Lu, Hongzhou, Xu, Jianqing“…We used the synergistic effect of both proteins to treat COVID-19. METHODS: We conducted an open-label, randomized, clinical trial involving patients with moderate COVID-19. …”
Publicado 2020
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572060por Greene, Naomi H., Kilpatrick, Sarah J., Wong, Melissa S., Ozimek, John A., Naqvi, Mariam“…OBJECTIVE: The objective of this study was to determine whether labor and delivery unit policy modifications we made during the coronavirus disease 2019 pandemic were associated with differences in outcomes for mothers and newborns. STUDY DESIGN: We conducted a retrospective cohort study of all deliveries occurring in our hospital between January 1, 2020, and April 30, 2020. …”
Publicado 2020
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