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301941por Whittaker, Kaylin, Hallman, Erin, Zanib, Aisha, Pfiffner, Samantha, Yaldo, Raquel, Dinda, Sumi“…Due to the endocrine-disrupting actions of phthalates, it is critical to further investigate DP’s potential impact on breast cancer cells. …”
Publicado 2023
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301942por McCosh, Richard B, Kreisman, Michael J, Jang, Jessica, Jung, Jacklyn, Breen Church, Kellie M“…Stress-induced hyperglycemia refers to the transient increase in blood glucose (BG) levels during stress, which occurs in healthy and diabetic patients. In critically ill patients, stress-induced hyperglycemia is associated with a 2-fold increase in risk of incident diabetes. …”
Publicado 2023
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301943“…Maintaining normal serum phosphorus levels in pregnant women with XLH is critically important to ensure mineralization of the fetal skeleton. …”
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301944por Fuentes-Fayos, Antonio C, Garcia-Garcia, Miguel E, Cano, David, Martínez-Fuentes, Antonio J, Di Caro, Isidoro, Gahete, Manuel D, Castaño, Justo P, Martínez-Barbera, Juan P, Soto-Moreno, Alfonso, Galvez-Moreno, Maria A, Jimenez-Vacas, Juan M, Luque, Raul M“…In vitro overexpression of these SFs in primary ACP-derived cells revealed a critical functional role of these factors in ACP. In fact, this overexpression induced the phosphorylation of MAPK and AKT pathways and reduced the phosphorylation JAK/STAT, NF-kB and TGFB that could be involved in the CP tumorigenesis. …”
Publicado 2023
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301945por Toyoizumi, Rebekka, Markgraf, Christopher Y, Starman, Alia, Rodriguez, Emily, Lee, Blake L, Bahn-Bales, Roxanne, Stricklin, Olivia, Estill, Charles, Roselli, Charles E, Chappell, Patrick E“…The multiphenotypic hypothalamic KNDy neurons play a critical role in the neuroendocrine regulation of reproduction, and via their stimulation of GnRH release, are requisite for fertility and pubertal progression. …”
Publicado 2023
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301946por Doi, Hibiki, Igarashi, Mizuho, Kashima, Takemoto, Ujita, Nagisa, Konno, Hiroaki, Fujioka, Akiko, Miyagi, Hajime, Yoshii, Keisuke, Naiki, Yasuhiro, Horikawa, Reiko“…Inspection using cystoscopy under general anesthesia is a useful option in recurrent PVB cases. It is critical to make the correct diagnosis because the treatments can be totally different. …”
Publicado 2023
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301947“…Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) are critical for the regulation of energy balance and glucose homeostasis. …”
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301948“…Healthy microglia are critical for neural development, maintenance of neural functions, and responses to stress, injury, or infection. …”
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301949“…Nevertheless, central hyperthyroidism could worsen underlying neurological diseases, given the critical role of TH in CNS and muscle. A greater awareness of both neurologists and endocrinologists on rare thyroid diseases is warranted, to improve the care of patients with neurological orphan diseases. …”
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301950“…Case Presentation: We are reporting the case of a 38-Year-old African American Female, who was involved in a car accident with non-critical injuries to her neck and chest area. She underwent a contrasted CT scan of her neck and chest that showed an anterior mediastinal mass towards the right at the level of the great vessels and arch, right paratracheal location overall measuring 6.0 x 4.6 x 4.5 cm. …”
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301951“…Our findings exemplify the critical role that PARP1 in macrophages plays in maintaining homeostasis in key metabolic tissues. …”
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301952por Ruf-Zamojski, Frederique Murielle, Cheng, Wan Sze, Zhang, Zidong, Zamojski, Michel, Smith, Gregory R, Chen, Xi, Mendelev, Natalia, Strupinsky, Galia, Alonso, Carlos Agustín, Gambino, Luisina Ongaro, Zhou, Xiang, Brule, Emilie, Amper, Mary Anne S, Hanna, Pincas, Nair, Venugopalan D, Andoniadou, Cynthia Lilian, Turgeon, Judith L, Troyanskaya, Olga, Zaslavsky, Elena, Bernard, Daniel J, Sealfon, Stuart C“…Additionally, we uncovered regulatory components of major pituitary genes over time using linkage data analysis.To our knowledge, this is the first study to present detailed and comprehensive data on gene expression and chromatin structure changes at sn resolution in all pituitary cell types during a dynamic physiological process. Thus, it provides critical new resources to the field of endocrinology. …”
Publicado 2023
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301953“…Moreover, Dac51 treatment altered the expression of several epigenetic regulators, including Sirt1 and 2, HDAC10 and SUV39H1, and rewiring of several critical pathways, including inflammation response, G2M checkpoint, and C-Myc signaling, among others, leading to suppression of uLMS phenotype. …”
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301954“…Hence, the recognition of the correlation of autoimmune-mediated diabetes and the variable time course to insulin deficiency is critical for the continued monitoring in patients with SPS. …”
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301955por Tantoush, Manal“…Continuous BG monitoring was utilized in 9 (16%). A critical sample was obtained in 18 (32%) with all evaluations consistent with hyperinsulinism. …”
Publicado 2023
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301956por Hanson, Alena J, Shah, Shriya, Wai, Ching Man, Bauer, Rosemary, Boots, Christina, Urbanek, Margrit“…Impact Statement: By integrating our transcriptomic data with whole exome sequencing (WES) data to assess the impact of genomic variation on ovarian cellular composition and transcriptional profiles, we will, for the first time, evaluate the impact of an individual woman’s genetic variation on their ovarian functional profile, a critical first step towards understanding the underlying pathology of PCOS and personalized medicine. …”
Publicado 2023
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301957por Carmen Rivadeneira, Ana Del, Kumar, Nankee, Banerjee, Shubhasree, Gubbiotti, Maria, Yoshor, Daniel, Kharlip, Julia, White, Caitlin A“…This case highlights the critical role in serologic evaluation and targeted pituitary biopsy to identify the specific etiology of pituitary infiltration to help guide alternate treatment options, and the emerging role of Rituximab as a steroid sparing agent for treatment of pituitary inflammation. …”
Publicado 2023
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301958“…Introduction: Outpatient follow up following hospital discharge is a critical factor in improving overall health outcomes especially among patients with chronic medical conditions. …”
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301959por Bell-Sambataro, Esther Eunice, Tatsi, Christina, Chittiboina, Prashant, Bowden, Sasigarn Arunchaiya“…Early diagnosis and treatment of CD are critical to prevent associated morbidities. Pituitary exploration by expert neurosurgery team should be considered in patients with MRI-negative CD. …”
Publicado 2023
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301960“…The initiation of lactation during postpartum days 1-4 is hormonally regulated and critical for successful breastfeeding. Insulin represents a key lactogenic hormone as evidenced by women with diabetes mellitus who have delayed lactation onset. …”
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