“…Access to LA PrEP for FSW is critical given the disproportionate impact of HIV on this community and their work-related PrEP preferences. …”
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“…DL-CAD as pre-screening reader shows the largest potential to be cost-saving. CRITICAL RELEVANCE STATEMENT: Deep-learning computer-aided lung nodule detection (DL-CAD) software must be priced substantially below 6 euro in a pay-per-case setting or must be used in high-workload environments with one-time investment in order to achieve break-even. …”
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“…Reasonable validity and reliability are critical for both the device and examiner before and after to testing in human subjects. …”
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“…The goal of the current study is to evaluate the anti-inflammatory and anticancer activity of three powerful phytocompounds—sitosterol, amyrin, and epiafzelechin—alone and in various therapeutic combinations against colon cancer to identify the critical mechanisms that mitigate nickel's carcinogenic effect. …”
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“…Investigation of meteorological data of both the regions reveals that the zone with higher seroprevalence has relatively higher rainfall, higher humidity, lower environmental temperatures, and higher altitude as the critical factors, potentially behind the significant difference seen in seroprevalence level. …”
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“…In a developing country like India where the intensive care facilities are scarce and rarely available, these critical patients have to be managed in high dependency cubicles in the ward, often with inadequately trained nursing staff and equipment to monitor them. …”
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“…The intron invasion, probably, spawned by the mitochondrial endosymbiont, might have critically contributed to the emergence of the principal features of the eukaryotic cell. …”
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“…Many of the existing non-linear methods have a couple of critical problems, the model selection problem and the model parameter tuning problem, that remain unsolved or even untouched. …”
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“…BACKGROUND: Cause of death data are a critical input to formulating good public health policy. …”
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“…These adjustments within the organism, some of which may be thought to exhibit an element of the purposeful, when considered with the test-tube experiments, strongly suggest that the reaction of the bile plays a critical part in determining the occurrence of carbonate stones, as furthermore that their absence from the normal gall bladder is a consequence of the changes in the bile reaction there occurring. …”
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“…With this reservation we may say that in the lowest concentrations attraction of the electrified water particles by the ions with the opposite charge prevails over the repulsion of the electrified water particles by the ions with the same sign of charge as that of the water; while beyond a certain critical concentration the repelling action of the ion with the same sign of charge as that of the water particles upon the latter increases more rapidly with increasing concentration of the solute than the attractive action of the ion with the opposite charge. 6. …”
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“…As soon as the P.D. of this double layer falls below 13 millivolts, the suspension is no longer stable. 6. The critical potential for the stability of suspensions of collodion particles coated with genuine egg albumin is the same as that for particles of boiled (denatured) white of egg. …”
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“…Outward currents of low density produce similar curves in the opposite direction, decreasing the positive P.D. by some 10 or 20 mv. with recovery on cessation of flow. Above a critical density of outward current, however, a new effect becomes superimposed; an abrupt reversal of the P.D. which now becomes 30 to 60 mv. negative. …”
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“…While evidence of an interfacial process in enzyme alteration has been adduced previously, critical proof of the interfacial hypothesis awaits creation of a model system, in which most of the aspects of intracellular alteration can be reproduced. 6. …”
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“…The epithelial Na(+) channel (ENaC), composed of three subunits (α, β, and γ), is expressed in several epithelia and plays a critical role in salt and water balance and in the regulation of blood pressure. …”
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“…Since I(AC) appears to set the membrane potential of AZF cells, these channels may function critically in coupling peptide receptors to membrane depolarization, Ca(2+) entry, and cortisol secretion. …”
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“…Cell migration was significantly decreased in three out of four PHA-L-treated cell lines, suggesting that β1–6 branched complex type N-oligosaccharides are critical for 92–1, Mel202, and FM55P cell motility. …”
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“…We reason that the complete lack of therapeutic effect of HB2 antibody and the reduced effect of HB2-SAPORIN in NOD/SCID mice is due to the reduced cytolytic activity of NOD/SCID NK cells which is probably below a certain critical threshold value in these animals. We conclude from this that immunotherapeutics like HB2-SAPORIN would be more accurately assessed for intrinsic potency in NOD/SCID mice where the effects of NK cell and possibly other non-adaptive immune mechanisms would not have a significant influence. © 2000 Cancer Research Campaign http://www.bjcancer.com…”
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“…We further evaluated primary melanomas of varying Breslow's tumor thickness to determine that the transition in expression occurs at different thicknesses for different genes suggesting that the "transition zone" represents a critical time for the emergence of the metastatic phenotype. …”
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“…Furthermore, the down-regulation of MYC and DP1 genes, which act as key transcription factors in cell growth control, together with the inhibition of BUB1, BUB3 and MAD2 mRNAs, which are known to be involved in the spindle checkpoint pathway, were specifically associated with the execution of senescence in U87-MG cells and addressed as critical factors that could drive the choice between different CPT-inducible effectors programs. …”
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