“…The presynaptic protein Munc18-1, alternatively spliced into long (M18L) or short (M18S) isoforms, is a critical modulator of neurotransmission. While subtle alterations in Munc18-1 have been shown to cause severe neuropsychiatric disorders with cognitive impairment, little information is known regarding the specific roles of Munc18-1 splice variants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Bacteria recovered from CMP-Leg5Ac7Ac-treated mice were sensitive to human complement ex vivo, simulating in vitro findings. These data reveal critical roles for the Sia exocyclic side-chain in gonococcal serum-resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Our results suggest that PI3K-Akt/FOXOa pathway is a critical mediator of vernodalin-induced cytotoxicity and this compound could be further developed as a potential chemopreventive or chemotherapeutic agent for breast cancer therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, the key goal of this study has been to contribute to an understanding of local and traditional plant usage, to evaluate their uses as food and medicine as well as to critically assess the role of these plants in the south of the Basque Country contributing to an understanding of how foods and medicines are used. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The endogenous stem/progenitor cells resident in organ and tissues play critical roles for organogenesis during development and for tissue homeostasis in adulthood. …”
Enlace del recurso
Enlace del recurso

“…Aggregation of PrP(Sc) into oligomers and fibrils is critically involved in the pathogenesis of prion diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: We used an ASC knockout mouse model, as ASC is a central protein in the inflammasome, acting as an adaptor and stabilizer of the complex and thus critical for its activation. Lipopolysaccharide (LPS)-primed primary cultures of astrocytes from newborn mice were utilized to evaluate Aβ-induced inflammasome activation by measuring IL-1β release by ECLIA (electro-chemiluminescence immunoassay). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The findings also indicate that age is one of the critical factors to be carefully considered when designing behavioral tests and interpreting behavioral differences that might be induced by experimental manipulations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Understanding the shape of the relationship between long-term exposure to ambient fine particulate matter (PM(2.5)) concentrations and health risks is critical for health impact and risk assessment. Studies evaluating the health risks of exposure to low concentrations of PM(2.5) are limited. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the pilot RCT we will: (1) define a minimal clinically important difference (MCID) for the primary outcome measure (total anxiety score using the Multidimensional Anxiety Scale for Children); (2) determine a sample size for the full-scale RCT; (3) estimate recruitment and retention rates; (4) measure intervention acceptability to inform critical intervention changes; (5) determine the use of co-interventions; and (6) conduct a cost-consequence analysis to inform a cost-effectiveness analysis in the full-scale RCT. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The challenges of identifying acute HIV infection (AHI) have resulted in a lack of critical information on early AHI that constrains the development of therapeutics that are designed to eradicate HIV from the infected host. …”
Enlace del recurso
Enlace del recurso

“…Continued monitoring of students and staff; 18. Documentation; 19. Critical Incident Review and annual review of the ER Plan; 20. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We prospectively assessed the abnormal blood glucose prevalence and the outcome and risk factors of deaths in critically ill children admitted to a national referral hospital in Laos. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Our data demonstrate a critical role of Mcl-1 in Her2-positive BC cell survival under hypoxic conditions and provide the preclinical framework for the therapeutic use of novel Mcl-1- targeting agents to improve patient outcome in BC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Ki67 labeling index (LI) is critical for treatment options and prognosis evaluation in breast cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Nuclear proteins play critical roles in regulating mRNA transcription and processing, DNA replication, and epigenetic genome modification. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Environmental burden of disease (EBD) attributable to residential radon among non-smokers is critical for identifying threats to population health and planning health policy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Involving end users in the design of these systems is critical to ensure a generation of usable and effective eHealth products and systems. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The complexity of the newer monitoring systems requires urgent usability testing and multidimensional interventions to improve alarm systems safety and to attain the Joint Commission National Patient Safety Goal on alarm systems safety in critical care units.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In several types of solid tumors, including breast cancers, the HIFs play a critical role in maintaining cancer stem cell (CSC) activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso