“…BACKGROUND: Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). …”
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“…The epigenetic readers of acetylated histones bromodomain and extra-terminal (BET) proteins are critical regulators of gene expression. In cancer, they can upregulate transcription of key oncogenes such as cMYC, IRF4, and BCL-2. …”
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“…BACKGROUND: Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by inflammation, demyelination, and neuronal degeneration, where myelin-specific CD4 T cells play critical roles in the formation of acute MS lesions and disease progression. …”
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“…We further propose that SWs play a critical role in tone development in the IAS through the generation and summation of phasic contractile activity. …”
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“…This study will also provide critical baseline data to characterize this vulnerable population. …”
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“…WIDER IMPLICATIONS: Intra-ovarian BMPs/GDFs are critical regulators of folliculogenesis and human ovarian functions. …”
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“…Well-orchestrated host responses together with effective viral clearance are critical for optimal clinical outcome after influenza infections. …”
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“…Mutational analysis using single amino acid substitutions within the globular head modules showed that Tyr(B175) and Lys(B136) were critical for the C1q–DC-SIGN/DC-SIGNR interaction. …”
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“…DISCUSSION: Results from this study showed the critical importance of initial selection and fitting of HPDs followed by verification (i.e., fit-testing) at Navy and Marine Corps accession points. …”
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“…Our method also achieved the highest F1 score on free-modeling targets in the latest CASP (Critical Assessment of Structure Prediction), although it was not fully implemented back then. …”
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“…Inclusion criteria were as follows: adult cancer survivors aged 18 years and over, cancer diagnosis, experience of participating in a telehealth intervention (defined as remote communication or remote monitoring with an HCP delivered by telephone, Internet, or hand-held or mobile technology), and reporting qualitative data including verbatim quotes. An adapted Critical Appraisal Skill Programme (CASP) checklist for qualitative research was used to assess paper quality. …”
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“…BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease and extensive evidence has indicated a critical role of both the innate and the adaptive arms of immune system in disease development. …”
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“…Rapid onset of effect of a parasiticide is critical to minimize the deleterious effects of these tick infestations, especially tick paralysis caused by the salivary neurotoxin. …”
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“…Urinary chitinase 3-like protein 1 (UCHI3L1) was found to predict AKI associated with critical illness in adults. Our aims were therefore to evaluate whether UCHI3L1 can also be used to predict AKI associated with elective cardiac surgery in adults, and to compare this predictive ability with that of urinary neutrophil gelatinase-associated lipocalin (UNGAL), more frequently assessed early serum creatinine (SCr) measurements, and various two-biomarker panels. …”
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“…The role of tropical forests in mitigating climate change is therefore critical. Over the past 30 years almost 600,000 km(2) have been deforested in Brazil alone due to the rapid development of Amazonia, this is the reason why currently the region is one of the ‘hotspots’ of global environmental change on the planet. …”
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“…These data taken together serve to highlight that functional Slc11a1(Gly169) can compensate the lack of TLR2/4/9. Thus Slc11a1 is a critical player in murine resistance to pulmonary Francisella infection, but not footpad infection.…”
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“…Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-negative lipopolysaccharide; however, its association with respiratory disease among agricultural workers is unknown. …”
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“…As such, lowering inflammation levels and maintain the viability of human retinal endothelial cells (HRECs) are critical for DR therapy. HMGB1 is a well-known proinflammatory cytokine. …”
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“…The delayed recognition of these VCFs and the patient's underlying osteoporosis after minor accident cases could present a major problem, as the critical time for patients to receive the proper medical or surgical treatments responsible for correcting and preventing further spinal deformity and pain has been reduced.…”
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“…Overall, our study demonstrates that carefully adjusting the different filtering parameters applied to the GBS data is critical to maximize the selection of high quality genotypes and to increase the accuracy of imputation of missing data. …”
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