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  1. 302241
    “…Within this context, a growing amount of evidence shows that alloreactive natural killer (NK) cells play a critical role in the immune response mechanisms elicited by the allograft. …”
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    KIR and their HLA Class I ligands: Two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation
  2. 302242
    “…BACKGROUND: Soybean seed weight is not only a yield component, but also a critical trait for various soybean food products such as sprouts, edamame, soy nuts, natto and miso. …”
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    Identification of QTL with large effect on seed weight in a selective population of soybean with genome-wide association and fixation index analyses
  3. 302243
    por Duz, Marco, Marshall, John F, Parkin, Tim
    Publicado 2017
    “…Manual classification required approximately 80 man-hours. CONCLUSIONS: The critical step in this work is the creation of accurate and inclusive dictionaries to ensure that no potential cases are missed. …”
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    Validation of an Improved Computer-Assisted Technique for Mining Free-Text Electronic Medical Records
  4. 302244
    “…The clinical utility of wPRx should be explored in prospective studies of critically injured neurological patients.…”
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    Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients: A retrospective study
  5. 302245
    “…Further rigorous research is needed that includes adequately powered studies examining the critical components of the intervention and the dosage needed to have an effect.…”
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    Online Artículo Texto
    Web-Based Interventions to Improve Mental Health, General Caregiving Outcomes, and General Health for Informal Caregivers of Adults With Chronic Conditions Living in the Community: Rapid Evidence Review
  6. 302246
    por Zhang, YueMei, Bhavnani, Bhagu R
    Publicado 2005
    “…Several lines of evidence also indicate that a family of cysteine proteases (caspases) appear to play a critical role in neuronal apoptosis. The purpose of the present study is to determine in primary cultures of cortical cells, if glutamate-induced neuronal apoptosis and its inhibition by estrogens involve changes in caspase-3 protease and whether this process is mediated by Fas receptor and/or mitochondrial signal transduction pathways involving release of cytochrome c. …”
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    Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
  7. 302247
    “…The anatomic findings are consistent with clinical studies on trochlear dysplasia in females, and suggests that trochlear development differences may play a critical role in patella instability.…”
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    Trochlear Development in Children from One Month to 10 Years of Age in Children from One Month to 10 Years of Age
  8. 302248
    “…Virus particles associate with lipoproteins, and apolipoprotein E (ApoE) is critical for HCV assembly and infectivity. However, whether ApoE dependency is common to all HCV genotypes remains unknown. …”
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    Hepatitis C Virus Strain-Dependent Usage of Apolipoprotein E Modulates Assembly Efficiency and Specific Infectivity of Secreted Virions
  9. 302249
    “…The sensitivity 85.2%, the specificity 76.3% and the critical value 0.4256. These indexes of tissue WIF-1 were 0.833, 86.7%, 75.4% and 0.3562 for CR, PR, SD and PD, respectively. …”
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    Value of the level of methylation of RASSF1A and WIF-1 in tissue and serum in neoadjuvant chemotherapeutic assessment for advanced breast cancer
  10. 302250
    “…Thematic analysis of the data was undertaken using Nvivo 9(®) software. Triangulation and critical case analysis was also used. RESULTS: There was a lack of formalized avenues through which field workers could report challenges experienced when conducting the malaria studies. …”
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    Maximizing research study effectiveness in malaria elimination settings: a mixed methods study to capture the experiences of field-based staff
  11. 302251
    “…For this to happen, parental guidance, schooling, and medical counseling are needed for a sound development of the child in this critical stage.…”
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    Internet Use and Access, Behavior, Cyberbullying, and Grooming: Results of an Investigative Whole City Survey of Adolescents
  12. 302252
    “…Optimal neuroanatomical lead position is a critical determinant of clinical outcomes in DBS surgery. …”
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    Online Artículo Texto
    Postoperative lead migration in deep brain stimulation surgery: Incidence, risk factors, and clinical impact
  13. 302253
    “…BACKGROUND: Malaria accounts for ~21% of outpatient visits annually in Kenya; prompt and accurate malaria diagnosis is critical to ensure proper treatment. In 2013, formal malaria microscopy refresher training for microscopists and a pilot quality-assurance (QA) programme for malaria diagnostics were independently implemented to improve malaria microscopy diagnosis in malaria low-transmission areas of Kenya. …”
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    Factors associated with malaria microscopy diagnostic performance following a pilot quality-assurance programme in health facilities in malaria low-transmission areas of Kenya, 2014
  14. 302254
    “…In the present study, we map the pathway by which Epac increases STOC activity in contractile vascular smooth muscle and show that a critical step is the activation of CaMKII. To our knowledge, this is the first report of CaMKII activation triggering cellular activity known to induce vasorelaxation. …”
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    Calcium/calmodulin‐dependent kinase 2 mediates Epac‐induced spontaneous transient outward currents in rat vascular smooth muscle
  15. 302255
    “…The aim of this study was to critically and systematically assess the efficacy of IL-Sb(v) for CL treatment. …”
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    Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review
  16. 302256
    “…BACKGROUND: Parenteral nutrition (PN) is used as nutritional support in patients that are malnourished, critically ill, and/or have a nonfunctional gut. Patients receiving PN are at increased risk for both infectious and noninfectious catheter complications often leading to increased morbidity and mortality. …”
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    Catheter-related Complications and Potential Risk Factors Among Catheterized Cancer Patients Receiving Parenteral Nutrition at The University of Texas MD Anderson Cancer Center: A 26,000 Parenteral Nutrition-day Experience
  17. 302257
    “…CONCLUSION: The HCV incidence in urban ED patients was over 60 times higher than the general US population and even higher in some high-risk groups, indicating ED is a critical venue for identifying high-risk individuals for HCV prevention and detecting HCV-infected Americans for treatment. …”
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    High Incidence of Hepatitis C Virus (HCV) Infection among an Urban Emergency Department (ED) Patients. 2003–2016.
  18. 302258
    “…Patient characteristics such as median age, days from admission to survey, and critical care location were similar. Urinary catheter prevalence was lower in 2015 (1,589/8,833, 18.0%) compared with 2011 (2,052/8,954, 22.9%, P < 0.0001), as was central line prevalence (2015: 1,539/8,833, 17.4%, vs. 2011: 1,687/8,954, 18.8%, P = 0.02). …”
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    Reduction in the Prevalence of Healthcare-Associated Infections in U.S. Acute Care Hospitals, 2015 vs 2011
  19. 302259
    “…These vulnerabilities could potentially be addressed through critically examining of impact of policies that indirectly promote or allow victimization of transgender citizens and subsequently diminish the effectiveness of public health and educational interventions. …”
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    Transgender female sex workers’ HIV knowledge, experienced stigma, and condom use in the Dominican Republic
  20. 302260
    “…Although some empirical evidence exists to suggest that various strategies may be used to convey emotion during Web-based text communication, there has been no critical review of these data in patients with chronic conditions. …”
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    Techniques for Improving Communication of Emotional Content in Text-Only Web-Based Therapeutic Communications: Systematic Review
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