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  1. 302281
    “…This methodology can be used where routine STI surveillance is limited and offers a new approach to obtaining critical information on STI and BV prevalence in LMICs.…”
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    Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies
  2. 302282
    “…Improving seat belt use remains a critical strategy to reduce crash-related deaths in the United States, especially in rural areas where seat belt use is lower and age-adjusted death rates are higher than in urban areas. …”
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    Rural and Urban Differences in Passenger-Vehicle–Occupant Deaths and Seat Belt Use Among Adults — United States, 2014
  3. 302283
    “…BACKGROUND: Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. …”
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    Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection
  4. 302284
    “…Detection and treatment of comorbid depression is critical to achieve viral load suppression in more than 90% of those on ART and is in line with the recent 90-90-90 Joint United Nations Programme on HIV/AIDS (UNAIDS) targets. …”
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    Collaborative care for the detection and management of depression among adults receiving antiretroviral therapy in South Africa: study protocol for the CobALT randomised controlled trial
  5. 302285
    “…Enhancing quality of care and health system transparency is critical for improving linkage of newly diagnosed patients to TB care in urban India. …”
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    Pretreatment loss to follow-up of tuberculosis patients in Chennai, India: a cohort study with implications for health systems strengthening
  6. 302286
    “…BACKGROUND: The presence of bridging syndesmophytes (BS) in spinal osteotomy region serves traditionally as one critical determinant for selection of osteotomy techniques. …”
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    The clinical relevance of the presence of bridging syndesmophytes on kyphosis correction and maintenance following pedicle subtraction osteotomy for thoracolumbar kyphotic deformity in ankylosing spondylitis: a comparative cohort study
  7. 302287
    “…. - Measurements with a wide range of small molecules of varying structures can indicate the critical molecular features required for recoupling and allows the prediction of other potential re-couplers.…”
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    Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin
  8. 302288
    “…The provision of easily accessible, evidence-based, and up-to-date information and resources about crystal methamphetamine for the community is a critical component of an effective public health response. …”
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    A Web-Based Toolkit to Provide Evidence-Based Resources About Crystal Methamphetamine for the Australian Community: Collaborative Development of Cracks in the Ice
  9. 302289
    “…However, cisplatin resistance remains a critical cause of treatment failure and a barrier to therapeutic advance in UBC. …”
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    SPIRE – combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial
  10. 302290
    por Shafner, Laura, Chah, Chloe
    Publicado 2018
    “…BACKGROUND: Remote patient monitoring is critical in ensuring optimal drug exposure. Between 30–50% of CNS trials fail because patients are not following the assigned protocol. …”
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    T53. USING ARTIFICIAL INTELLIGENCE PLATFORMS TO ENHANCE STUDY DESIGN IN SCHIZOPHRENIA TRIALS
  11. 302291
    “…BACKGROUND: A large number of clinical and preclinical studies suggest that dysfunction at synapses for the excitatory neurotransmitter glutamate may play a critical role in the pathophysiological changes that underlie each of the major symptom clusters observed in schizophrenia patients. …”
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    43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA
  12. 302292
    por Bortz, David, Grace, Anthony
    Publicado 2018
    “…One pathway that is critical for DA regulation originates from the ventral subiculum (vSub) of the hippocampus and controls ventral tegmental area (VTA) DA neuron activity. …”
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    S40. MEDIAL SEPTUM ACTIVATION PRODUCES OPPOSITE EFFECTS ON DOPAMINE NEURON ACTIVITY IN THE VENTRAL TEGMENTAL AREA AND SUBSTANTIA NIGRA PARS COMPACTA IN MAM VERSUS NORMAL RATS
  13. 302293
    “…Especially PE-S have been criticized for being over-inclusive and not capturing the essence of low-grade psychosis. …”
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    S29. CONCORDANCE BETWEEN SELF-REPORT AT INTERVIEW-BASED RATINGS OF PSYCHOTIC EXPERIENCES IN PRE-ADOLESCENCE AND ASSOCIATED PSYCHOPATHOLOGY
  14. 302294
    “…Together, these findings have important therapeutic implications for potentiating improvements in self-agency judgments not only in HC, but in patients with schizophrenia who suffer from critical self-agency impairments.…”
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    F149. NEUROBIOLOGY OF SELF-AGENCY DURING REALITY MONITORING AND SPEECH FEEDBACK MONITORING: IMPLICATIONS FOR TREATMENT DEVELOPMENT IN SCHIZOPHRENIA
  15. 302295
    “…Examining the state of mIns deficit is a critical step to delineate the role of astroglial cells in schizophrenia. …”
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    S10. ASTROGLIAL PATHOLOGY IN SCHIZOPHRENIA: A META-ANALYSIS OF MRS STUDIES OF ANTERIOR CINGULATE MYOINOSITOL
  16. 302296
    por Purves-Tyson, Tertia
    Publicado 2018
    “…Tertia Purves-Tyson will present the first post mortem evidence that neuroinflammation in SCZ extends to the midbrain, a region critical for psychosis and cognitive deficits. She will show that: 1. gene expression of multiple pro-inflammatory cytokines is increased in the post mortem substantia nigra in SCZ compared to controls, in whose brains no such changes are seen; 2. as in the cortex, gene expression changes were found only in a subset of cases (~50%) of the SCZ cohort. …”
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    40. NEW INSIGHTS ON THE ROLE OF NEUROINFLAMMATION IN SCHIZOPHRENIA PATHOPHYSIOLOGY FROM POST MORTEM AND ANIMAL STUDIES
  17. 302297
    “…It involves several cognitive processes that are considered as critical for an adapted social functioning. In patients with schizophrenia (SCZ) and subjects prone to psychosis (PP), a number of studies have revealed impairments in the abilities to infer beliefs, intentions or emotions of others. …”
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    S143. NEURAL CORRELATES OF INTENTION AND BELIEF INFERENCE RELATIVE TO EMOTION ATTRIBUTION TO OTHERS IN SCHIZOPHRENIA AND PSYCHOSIS PRONENESS: ACTIVATION LIKELIHOOD ESTIMATION META-ANALYSIS
  18. 302298
    “…BACKGROUND: The thalamus, a critical node in which multiple cerebral circuits converge, is organized into multiple subnuclei, classified as either first-order (receiving peripheral sensory input) or higher-order (receiving input primarily from the cortex). …”
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    F177. THALAMIC SUBREGION RESTING STATE CONNECTIVITY IN SCHIZOPHRENIA MEASURED AT 7T
  19. 302299
    “…METHODS: A systematic-review of the literature was undertook to review the available internet-based psychological interventions for bipolar disorder and provide a critical appraisal of the studies and platforms included. …”
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    4.4 INTERNET-BASED INTERVENTIONS FOR BIPOLAR DISORDER
  20. 302300
    “…Allowing for realistic goal setting and positive feedback, while minimizing usability burdens, seems to be critical for the adoption of such apps. Fatigue management is especially important in this population; more attention should be brought to this area.…”
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    Exploring the Specific Needs of Persons with Multiple Sclerosis for mHealth Solutions for Physical Activity: Mixed-Methods Study
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