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  1. 302301
    “…The presence of systemic inflammatory response syndrome (SIRS), severe sepsis, and septic shock were assessed and documented based on the consensus criteria of the American College of Chest Physicians and Society of Critical Care Medicine (SEPSIS-I) in infected patients. …”
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    Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study
  2. 302302
    “…In the 2012 and 2015 TAS, thirteen and six ICT/FTS positive cases, respectively, were identified, which were significantly below the critical cut-off (18–20 cases) across all evaluation units. …”
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    Surveillance for lymphatic filariasis after stopping mass drug administration in endemic districts of Togo, 2010–2015
  3. 302303
    “…CONCLUSIONS: One-third of critically ill patients are admitted to the ICU afterhours. …”
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    Association between afterhours admission to the intensive care unit, strained capacity, and mortality: a retrospective cohort study
  4. 302304
    “…BACKGROUND: Estrogen plays a critical role in breast cancer (BC) progression through estrogen receptor (ER)-mediated gene regulation. …”
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    Estrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer
  5. 302305
    “…BACKGROUND: Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. …”
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    Interactive Two-Way mHealth Interventions for Improving Medication Adherence: An Evaluation Using The Behaviour Change Wheel Framework
  6. 302306
    “…We also found the first interspecies recombinant between HHV-6A and HHV-6B, a phenomenon that is well known in alphaherpesviruses but to date has not been seen in betaherpesviruses. These data critically inform HHV-6A/B biology and the standard selection process.…”
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    Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains
  7. 302307
    “…The nNOS was shown to play critical roles in a variety of muscle functions and alterations of its expression and location in dystrophic muscle fiber leads to an increase of the muscle fatigability. …”
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    miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context
  8. 302308
    “…Recruiting eligible research participants for a contraceptive efficacy study and enrolling an adequate number to statistically assess the effectiveness of Dot is critical. Recruiting and enrolling participants for the Dot study involved making decisions based on research and analytic data, constant process modification, and close monitoring and evaluation of the effect of these modifications. …”
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    Lessons From the Dot Contraceptive Efficacy Study: Analysis of the Use of Agile Development to Improve Recruitment and Enrollment for mHealth Research
  9. 302309
    “…Tailoring mobile apps to the language and needs of Spanish-speaking MSM is critical to help increase their willingness to download a mobile app. …”
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    Developing Sustainable and Impactful Mobile Phone HIV Testing Interventions for Spanish-Speaking Men Who Have Sex With Men in the United States: Lessons Learned From Informative Interviews
  10. 302310
    “…The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue. …”
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    The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex
  11. 302311
    “…To support national progress towards elimination, it is critical to verify and understand these changes in disease burden. …”
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    Prevalence and risk factors for asymptomatic malaria and genotyping of glucose 6-phosphate (G6PD) deficiencies in a vivax-predominant setting, Lao PDR: implications for sub-national elimination goals
  12. 302312
    “…To address this gap, we designed and are implementing a randomized controlled trial (RCT) to test the efficacy of the Thrive with Me intervention for MSM living with HIV. Critical components of the protocol are presented. …”
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    Thrive With Me: Protocol for a Randomized Controlled Trial to Test a Peer Support Intervention to Improve Antiretroviral Therapy Adherence Among Men Who Have Sex With Men
  13. 302313
    “…Articles meeting the inclusion criteria were critically appraised by 2 reviewers using a modified version of the COnsensus-based Standards for the selection of health Measurement INstruments. …”
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    A Core Set of Outcome Measures for Adults With Neurologic Conditions Undergoing Rehabilitation: A CLINICAL PRACTICE GUIDELINE
  14. 302314
    “…Nutrient intake during infancy is critical for healthy growth and development. The present study examined egg consumption and associations with nutrient intakes, markers of growth and weight-related measures in infants 6–24 months of age (N = 561) compared to infant egg non-consumers (N = 2129). …”
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    Egg Consumption in Infants is Associated with Longer Recumbent Length and Greater Intake of Several Nutrients Essential in Growth and Development
  15. 302315
    “…Discovery and elucidation of the mechanism underlying estrogen-promoted NSCLC progression is critical for effective preventive interventions. IL6 has been demonstrated to be involved in the development, progression and metastasis in several cancers and IL6 overexpression is associated with poor prognosis in NSCLC. …”
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    17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression
  16. 302316
    “…Unfortunately, little methodological research has been done to compare automatic coding using NLP techniques and qualitative coding, which is critical to establish the viability of NLP as a useful, rigorous analysis procedure. …”
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    Augmenting Qualitative Text Analysis with Natural Language Processing: Methodological Study
  17. 302317
    “…PD-L1 expression in clinical practice is determined by testing one tumor section per patient. Therefore, it is critical to understand the impact of tissue sampling variability on patients’ PD-L1 classification. …”
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    Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay
  18. 302318
    “…Moreover, neuromuscular components, especially knee muscular strength and the strength balance ratio, also seem to be critical for the running economy. In addition to knee muscle strength, hip muscle strength is also an important contributor to running performance on level or hilly ground. …”
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    Hip muscular strength balance is associated with running economy in recreationally-trained endurance runners
  19. 302319
    “…BACKGROUND: Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome (ARDS) is still unclear. …”
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    Diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome
  20. 302320
    “…To help the 6.5 million U.S. adults and families affected by heart failure manage the high symptom burden, complex decision-making, and risk of exacerbation and death, the early integration of palliative care is critical and has been recommended by numerous professional organizations. …”
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    Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcare for Patients and Caregivers (ENABLE CHF-PC): study protocol for a randomized controlled trial
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