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  1. 302341
    “…The rate of fluoroquinolone resistance was high and empiric quinolones should be used with caution for patients who are critically ill due to E-CAP DISCLOSURES: A. Deshpande, 3M: Investigator, Research support; Clorox: Investigator and Speaker’s Bureau, Research grant and Speaker honorarium; Merck: Investigator and Speaker’s Bureau, Research support.…”
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    1457. Escherichia coli Community Acquired Pneumonia
  2. 302342
    “…The clinical algorithm for IPA diagnosis in critically-ill patients was used to separate colonization from proven or probable infection. …”
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    1488. Invasive Pulmonary Aspergillosis in Patients with Solid Tumors: Risk Factors and Predictors of Clinical Outcomes
  3. 302343
    “…Host-based diagnostics may play a critical role in improving diagnostic ability and antibiotic use globally. …”
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    2018. Host Gene Expression Classifiers Distinguish Bacterial and Viral Infections in Sri Lankan Patients with Acute Febrile Respiratory Illness
  4. 302344
    “…BACKGROUND: Enterococci often cause hospital-associated bloodstream infections in critically ill and immunocompromised patients. Prospective studies to assess the clinical impact of enterococcal bacteremia (EB) are lacking. …”
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    1009. Venous 1: A Prospective Multicenter Cohort Study of Enterococcal Bacteremia
  5. 302345
    “…BACKGROUND: Ventilator-associated pneumonia (VAP) is one of the most commonly encountered hospital-acquired infections worldwide, and one of the major contributors to an over mortality in critically ill patients. Initial empirical antimicrobial therapy is often broad-spectrum. …”
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    2002. Evaluation of the BioFire(®) Pneumonia Panel in ICU Patients With Suspected Ventilator-Associated Pneumonia
  6. 302346
    “…Antibiograms provide critical information for clinicians to strategically use antibiotics. …”
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    451. High-Frequency of Multi-Drug-Resistant Organisms (MDRO) at University Teaching Hospital (UTH), Lusaka, Zambia
  7. 302347
    “…In a multivariate logistic regression analysis, type of drinking water source [AOR = 3.69; 95% CI: 2.03–6.71], mothers not hand washing at critical times [AOR = 15.42; 95% CI: 2.02–117.78], improper solid waste disposal [AOR = 12.81; 95% CI: 2.50–65.62], and child age (36–47 months) [AOR = 2.57; 95% CI: 1.45–4.55] were found to be predictors of diarrhoea. …”
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    Risk factors for diarrhoea and malnutrition among children under the age of 5 years in the Tigray Region of Northern Ethiopia
  8. 302348
    “…USP37 is required for the regulation of breast cancer progression, as well as a critical target for clinical treatment of breast cancer. …”
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    Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity
  9. 302349
    “…Mitogen-activated protein kinase (MAPK) signaling pathway has been suggested to play a critical role during the process of inflammation, insulin resistance, and T2DM. …”
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    Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway
  10. 302350
    “…Cumulative live birth rate, live birth rate and pregnancy loss rate (or miscarriage rate) were considered the critical outcomes. PARTICIPANTS/MATERIALS, SETTING, METHODS: Based on the collected evidence, recommendations were formulated and discussed until consensus was reached within the guideline group. …”
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    ESHRE guideline: recurrent pregnancy loss
  11. 302351
    “…Two authors independently reviewed studies for possible inclusion and critically appraised selected manuscripts. Data were analysed descriptively, being unsuitable for statistical analysis. …”
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    Availability, effectiveness and safety of ART in sub-Saharan Africa: a systematic review
  12. 302352
    por Bantia, Shanta, Choradia, Nirmal
    Publicado 2018
    “…Designing trials rigorously to address the optimum treatment duration with immune based therapies is critical. By addressing this concern now, not only we may improve patient outcomes, but also gather a deeper understanding of the role and mechanisms of the immune system in the control of tumor growth. …”
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    Treatment duration with immune-based therapies in Cancer: an enigma
  13. 302353
    “…However, those techniques have some limitations: Dual-Source CT imaging can lead to increased radiation exposure, and switching of the tube voltage (rapid kVp switching) can be associated with slower rotation speed of the gantry and is thus prone to motion artefacts that are especially critical in cardiac imaging. Both techniques cannot simultaneously acquire spectral data. …”
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    Accuracy of Calcium Scoring calculated from contrast-enhanced Coronary Computed Tomography Angiography using a dual-layer spectral CT: A comparison of Calcium Scoring from real and virtual non-contrast data
  14. 302354
    “…The progressive ankylosis protein (gene ANKH; protein ANKH) and ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1/ENPP1) increase PP(i) and inhibit mineralization, while tissue-nonspecific alkaline phosphatase (ALPL; TNAP) is a critical pro-mineralization enzyme that hydrolyzes PP(i). …”
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    Basic fibroblast growth factor regulates phosphate/pyrophosphate regulatory genes in stem cells isolated from human exfoliated deciduous teeth
  15. 302355
    “…The app is intended to enhance vector surveillance activities by giving inspectors the opportunity to incorporate the infestation risk information into their surveillance activities, but it does not dictate which houses to surveil. Therefore, a critical question becomes, will inspectors use the risk information? …”
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    Integrating evidence, models and maps to enhance Chagas disease vector surveillance
  16. 302356
    “…BACKGROUND: The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially understood mechanisms. …”
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    ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth
  17. 302357
    “…KS is an important AIDS-defining tumor with high prevalence in Sub-Saharan Africa, including Tanzania which has high HIV and HHV-8 sero-prevalence. It is critically important to monitor the prevalence of AIDS-defining tumors, such as KS, in the age of HIV/AIDS. …”
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    Prevalence and associated risk factors for Kaposi’s sarcoma among HIV-positive patients in a referral hospital in Northern Tanzania: a retrospective hospital-based study
  18. 302358
    “…Providing proof for type II NER is the most critical issue in NER assessment and requires additional research. …”
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    A unified approach for including non-extractable residues (NER) of chemicals and pesticides in the assessment of persistence
  19. 302359
    “…METHODS: Cohort studies published in English language from 2005 to 2018 were retrieved from seven databases. Critical appraisal of studies was carried out using the Scottish Intercollegiate Guidelines Network (SIGN) checklist. …”
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    Seatbelt use and risk of major injuries sustained by vehicle occupants during motor-vehicle crashes: a systematic review and meta-analysis of cohort studies
  20. 302360
    “…BACKGROUND: Understanding how users engage with electronic screening and brief intervention (eSBI) is a critical research objective to improve effectiveness of app-based interventions to reduce harmful alcohol consumption. …”
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    Developing Typologies of User Engagement With the BRANCH Alcohol-Harm Reduction Smartphone App: Qualitative Study
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