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  1. 302381
    “…IMPORTANCE: As opioid-related mortality continues to increase, naloxone remains a critical intervention in preventing overdose death. …”
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    Naloxone Prescriptions Among Commercially Insured Individuals at High Risk of Opioid Overdose
  2. 302382
    “…These enzymes are vital for tumor invasion and metastasis and also play a critical role in several other stages of tumor development and progression. …”
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    Strong association of tissue inhibitor of metalloproteinase (TIMP)-2 and -3 promoter single nucleotide polymorphisms with risk of colorectal cancer in ethnic Kashmiri population – a case control study
  3. 302383
    “…These findings provide a novel pathogenic mechanism on how H. pylori can survive in the gastric epithelium, and a unique pathway for vitamin D3 to reactivate the autolysosomal degradation function, which is critical for the antibacterial action of vitamin D3 both in cells and in animals, and perhaps further in humans. …”
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    Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells
  4. 302384
    por Chao, Dyna YP, Lin, Tom MY, Ma, Wen-Ya
    Publicado 2019
    “…Devices and mobile app in the Internet of Things (IoT) have become critical self-management tools for collecting and analyzing personal data to improve individual health outcomes. …”
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    Enhanced Self-Efficacy and Behavioral Changes Among Patients With Diabetes: Cloud-Based Mobile Health Platform and Mobile App Service
  5. 302385
    “…Observing their progressive accumulation in the brains of clinically normal older adults is critically important to understand the pathophysiologic cascade leading to AD and to inform the choice of outcome measures in prevention trials. …”
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    Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study
  6. 302386
    “…BACKGROUND: Apoptosis plays a critical role in the embryonic development, homeostasis of immune system and host defense against intracellular microbial pathogens. …”
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    Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1
  7. 302387
    “…BACKGROUND: Abnormal expression of the eukaryotic initiation factor 3 (eIF3) subunits plays critical roles in tumorigenesis and progression, and also has potential prognostic value in cancers. …”
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    Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma
  8. 302388
    “…These risk factors in combination, in a diabetes background may augment the risk of CV disease in transmen, as such early and aggressive glucose control and management of risk factors is of critical importance. Clinicians need to be aware of HbA1c’s limitations in this population with diabetes, to prevent delays in diagnosis and timely intensification of treatment. …”
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    MON-LB045 Inaccurate Hemoglobin A1c in a Transman Patient with Diabetes: Implications for Treatment and Surveillance
  9. 302389
    “…However, the choice of which isotope to monitor is critically important as intact IGF-I produces a wide isotopic envelope of up to 13 detectable peaks. …”
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    MON-487 Simultaneous Monitoring of 13 IGF-1 Variants in a Clinical Mass Spectrometry Assay
  10. 302390
    “…Larger studies are needed to better understand potential metabolic benefits of metformin treatment in obese youth during puberty, a critical window of metabolic change.…”
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    SAT-247 Two-Year Treatment with Metformin during Puberty Is Associated with Improvements in Body Composition, but Not in Insulin Sensitivity or β-Cell Function in Obese Youth
  11. 302391
    “…We suppose FAT1 mutations are potential drivers and Wnt/β-catenin pathway plays a critical role in this distinct thyroid malignancy.…”
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    SAT-567 Mutational Profile of Hurthle Cell Carcinomas: Recurrent Mutations in Wnt/β-catenin Pathway Genes
  12. 302392
    “…Pilot data were underpowered to generate robust findings, but provided insights: 1) hCG-alpha has a distinct correlation structure, different from the other forms of hCG, in relation to MnBP, thyroid hormone, and infant cognition; 2) these data offer support for the theory that hCG-alpha supplants TSH during this critical period of brain development. Endocrine pathways in pregnancy are related to fetal brain development and vulnerable to phthalate exposure. …”
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    SAT-229 HCG Alpha Might Supplant TSH during the Fetal Period to Promote Brain Development
  13. 302393
    “…Leptin is a critical mediator of metabolic regulation of the hypothalamic-pituitary gonadal (HPG) axis. …”
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    SAT-406 Deletion of Musashi in Gonadotropes Leads to Increased GnRHR Protein Levels and Gonadotrope Dysfunction
  14. 302394
    “…To select the best test for a patient, knowledge of the performance and limitations of each test is critical. OBJECTIVE: This systematic review has summarized recent studies evaluating HSV-1 and HSV-2 diagnostic tools. …”
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    Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018
  15. 302395
    “…Developing and testing a novel mobile system for patients with HF that incorporates chronic disease management is critical for advancing research and clinical practice of care for them. …”
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    A Patient-Centered Mobile Phone App (iHeartU) With a Virtual Human Assistant for Self-Management of Heart Failure: Protocol for a Usability Assessment Study
  16. 302396
    “…Shortly before ovulation the LH surge induces processes critical for fertility, including cumulus-oocyte expansion (C-OE) and resumption of meiosis. …”
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    SAT-192 Chemokine Receptor CCR2 as a Novel Mediator of LH Signaling
  17. 302397
    “…Thyroid hormone (TH) is critical for a diverse range of biological functions, and TH action is controlled at many levels including production, secretion, transport into the cell, TH receptor and cofactor expression, and by tissue- and cell-specific local deiodination that can either activate or inactivate TH. …”
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    SAT-LB094 The Role of Thyroid Hormone in the Beneficial Effects of Stretching
  18. 302398
    “…However, due to underlying inability to mount cortisol response to illness, it is critical to implement a Sick Day Protocol (SDP). We present the case of septic shock due to pneumonia, in a patient with secondary hypocortisolism following meningeal tumor resection. …”
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    SUN-LB066 Assessing the Need for Individualized Sick Day Protocol in a Patient with Secondary Adrenal Insufficiency and Pneumonia
  19. 302399
    “…Growth hormone deficiency is not often listed in the differential diagnoses. Growth hormone is critical for longitudinal bone growth. ALP is a known marker of bone formation. …”
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    SUN-LB051 Low Alkaline Phosphatase? Rule out Growth Hormone Deficiency.
  20. 302400
    “…Hence, early recognition of HP as an etiology of FS is critical.…”
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    SUN-516 Fahr's Syndrome: A Rare Sequela of Hypoparathyroidism
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