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  1. 302401
    “…She underwent an 8-hour fast at DOL12 but developed hypoglycemia with blood glucose of 47 mg/dl at the end of the fast. A critical sample was obtained which showed cortisol of 12 mcg/dl (6.2-19.4), insulin of 7.2 uIU/ml (2.6-24.9), GH of 27.4 ng/dl (0.0-10.0), betahydroxybutyrate of 3.5 mg/dl (0.2-2.8), and free fatty acid of 0.6 mEq/L (0.1-0.6). …”
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    SUN-269 Novel Mutation of the HNF1A Gene in a Patient with Congenital Hyperinsulinism
  2. 302402
    “…She was deemed a poor surgical candidate for adrenalectomy due to critical illness and advanced cancer. Elevated transaminases related to necrotic liver lesions precluded use of ketoconazole. …”
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    SUN-LB068 Ectopic Cushing Syndrome Due to a Metastatic Neuroendocrine Tumor Treated with Metyrapone
  3. 302403
    “…Triple negative breast cancer (TNBC) is the most metastatic and deadliest breast cancer (BC) subtype, accounting for 20-30% of all BCs. There is a critical need to identify molecular targets that could be exploited as new biomarkers of TNBC prognosis and for improving therapies. …”
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    SUN-008 The Glucocorticoid Receptor Is Essential For TGFβ and p38 MAPK Mediated Cancer Phenotypes in Triple Negative Breast Cancer
  4. 302404
    “…One factor that influences the choice of radiation modality is proximity of tumor to local critical anatomy, namely the optic chiasm (2). MRI is the modality of choice for evaluating pituitary tumors, postoperative resection cavities and the relationship between tumor and the optic chiasm (3). …”
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    SUN-459 Analysis of the Evolution of Postoperative Pituitary Resection Cavities Assessed by Magnetic Resonance Imaging and Implications Regarding Choice of Radiation Therapy Modality
  5. 302405
    “…For MTC, active surveillance with imaging and biochemical markers is critical for management. Doubling time of calcitonin <1 year and rising CEA levels should prompt suspicion for disease progression.…”
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    SUN-596 A Rare Case of Metastatic Medullary Thyroid Carcinoma to Pituitary Gland
  6. 302406
    “…We hypothesize that β cell miR-21 plays a critical role in inhibiting β cell function and inducing loss of β cell identity. …”
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    OR05-3 Mir-21 Contributes to Cytokine-Induced Beta Cell Dysfunction via Inhibition of mRNAs Regulating Beta Cell Identity
  7. 302407
    “…We assembled a comprehensive “line-up” of the 36 protein coding loci in the 1.5 Mb minimal critical deleted region on hChr22q11.2, plus 20 protein coding loci in the distal 1.5 Mb that defines the 3 Mb typical 22q11DS deletion. …”
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    In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?
  8. 302408
    “…Also, PDI is present in circulation and at the cell surface of platelets, lymphocytes, erythrocytes and endothelial cells and plays a critical role in initiating thrombus formation. However, the interaction of RAS and PDI remain unclear. …”
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    OR04-5 Stimulation of Protein Disulfide Isomerase Activity by Activation of The Renin-Angiotensin System
  9. 302409
    “…Guidance in designing entomological surveillance systems is critical, and these systems may pursue different specific objectives depending on the disease. …”
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    Towards harmonisation of entomological surveillance in the Mediterranean area
  10. 302410
    “…The human pneumococcal standard reference serum, lot 89SF, greatly facilitated the standardization of enzyme-linked immunosorbent assay methodologies during a critical period when the first pneumococcal polysaccharide-conjugate vaccines were being evaluated for licensure. …”
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    Assignment of Serotype-Specific IgG1, IgG2, and IgA Weight-Based Antibody Units to the Human Pneumococcal Standard Reference Serum, 007sp
  11. 302411
    “…In this article, we report on the role of novel and quantitative imaging techniques across a range of imaging modalities in ILD and consider how they may be applied in the assessment and understanding of ILD. We critically appraised evidence found from searches of Ovid online, PubMed and the TRIP database for novel and quantitative imaging studies in ILD. …”
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    Experimental and quantitative imaging techniques in interstitial lung disease
  12. 302412
    “…BACKGROUND: A critical issue in understanding the benefits of Web-based interventions is the lack of information on the sustainability of those benefits. …”
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    Understanding Long-Term Trajectories in Web-Based Happiness Interventions: Secondary Analysis From Two Web-Based Randomized Trials
  13. 302413
    “…This study performed a systematic evaluation of the nature and degree of mitochondrial‐derived H(2)O(2) emission and mitochondrial oxidative dysfunction in a mouse model of DMD by designing in vitro bioenergetic assessments that attempt to mimic in vivo conditions known to be critical for the regulation of mitochondrial bioenergetics. …”
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    Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H(2)O(2) emission during impaired oxidative phosphorylation
  14. 302414
    “…CONCLUSIONS: Our findings reveal that gut dysbiosis is a critical factor for a high-fructose diet-induced hippocampal neuroinflammation in C57BL/6N mice possibly mediated by impairing intestinal epithelial barrier. …”
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    Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids
  15. 302415
    “…BACKGROUND: ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. …”
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    Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
  16. 302416
    “…Soils impact global carbon cycling and their resident microbes are critical to their biogeochemical processing and ecosystem outputs. …”
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    Towards optimized viral metagenomes for double-stranded and single-stranded DNA viruses from challenging soils
  17. 302417
    “…BACKGROUND: Spatially accurate population data are critical for determining health impacts from many known risk factors. …”
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    Population allocation at the housing unit level: estimates around underground natural gas storage wells in PA, OH, NY, WV, MI, and CA
  18. 302418
    “…Long noncoding RNAs have emerged as critical regulators in cancer. Long intergenic noncoding RNA-p21, a kind of Long noncoding RNAs, LincRNA-p21 have been discussed dysregulated in several cancers, but its role in ESCC remains unknown. …”
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    LincRNA-p21 leads to G1 arrest by p53 pathway in esophageal squamous cell carcinoma
  19. 302419
    “…DISCUSSION: This trial, utilizing an economically feasible, community-vetted cookstove and evaluating endpoints relevant for the major causes of morbidity and mortality in LMICs, will provide critical information for household air pollution stakeholders globally. …”
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    Study protocol for a stepped-wedge randomized cookstove intervention in rural Honduras: household air pollution and cardiometabolic health
  20. 302420
    “…BACKGROUND: Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities. …”
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    Health inequities in the diagnosis and outcome of sepsis in Argentina: a prospective cohort study
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