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  1. 302441
    “…Usual methods, used since 2010 by the PRR group, included public advertisements requiring the patient to call the research team for more information and education of eligible patients identified during routine clinical care with a Pulmonary/Critical Care clinician or when enrolling in a pulmonary clinical trial. …”
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    2300: E-prescribing research participation: Feasibility of recruiting research participants using an EMR-integrated health information technology
  2. 302442
    “…To maximize effectiveness of the cluster, other members are decision-makers in the organizations they represent, or serve in a critical staff function. Clusters meet in person on a quarterly basis with more frequent electronic interaction. …”
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    2514: Governance for a decentralized informatics academic environment
  3. 302443
    “…OBJECTIVES/SPECIFIC AIMS: Because clinical trial results are instrumental in the approval of a new drug or changes to the practice of medicine, ensuring the accuracy and validity of collected data is critical in the clinical trial process. This function, routinely carried out by clinical trial monitors in industry-sponsored trials, is often lacking in investigator-initiated trials (IITs) conducted in academia. …”
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    3080 Ensuring Quality in Investigator-Initiated Clinical Trials through Monitoring Concepts Training
  4. 302444
    “…To more effectively combine therapy it is critical that we understand how currently utilized therapy works. …”
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    2363 Inducing anti-tumor immunity in colorectal cancer
  5. 302445
    por Flippin, Michelle
    Publicado 2018
    “…However, fathers use interaction styles and language models that are different from mothers and may benefit children with ASD in unique ways. Thus there is a critical need in the field to expand our understanding of the potential contributions of various caregivers to communication outcomes. …”
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    2022 Using father-mediated intervention to increase responsive parental behaviors and child communication in children with autism spectrum disorder: A pilot study
  6. 302446
    “…Drug interactions, critically ill state and change in drug formulation were major causes of intra-patient variability. …”
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    2107. Azole Therapeutic Drug Monitoring (TDM) in a Multiracial Cohort with Varied Pharmacogenetics
  7. 302447
    “…Population-based metrics of PrEP uptake and access are critical to the evaluation of public health efforts to increase PrEP use. …”
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    1270. Population-Based Estimates of PrEP Access in Oregon, 2012–2016
  8. 302448
    “…BACKGROUND: Understanding drug resistance in perinatally HIV-infected children (PHIC) when viral load (VL) monitoring is limited is critical for life-long antiretroviral use. Resistance data in PHIC in sub-Saharan Africa are limited. …”
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    885. HIV-1 Treatment Failure and Extensive Drug Resistance in Perinatally Infected Children Failing First-Line Antiretroviral Therapy in Western Kenya
  9. 302449
    “…Future studies evaluating the effectiveness of interventions to reduce GC/CT among 11–24 years old are critically needed. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures.…”
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    418. Testing and Positivity Rates for Gonorrhea and Chlamydia in a Large Federally Qualified Health Center System
  10. 302450
    “…CONCLUSION: nAb against CMV PC-mediated cell entry did not appear to play a critical role in viral clearance in SL CMV infection after CMV D+/R- allogeneic HCT. …”
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    2591. The Role of Neutralizing Antibodies (nAb) Against Cytomegalovirus (CMV) Epithelial Cell-entry in Patients with Self-limited (SL) CMV infection after Hematopoietic Cell Transplantation (HCT)
  11. 302451
    “…Identifying high-risk populations for RSV infection are critical to inform clinical practice and future RSV vaccine policy. …”
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    2797. Rates of Respiratory Syncytial Virus (RSV) Infection among Hospitalized Adults by Congestive Heart Failure Status—United States, 2015–2017
  12. 302452
    “…CONCLUSION: In this cohort of critically-ill patients with CRE infection, tx with M/V yielded outcomes comparable to prior cohorts treated with ceftazidime–avibactam. …”
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    2247. Real-world Experience with Meropenem–Vaborbactam (M/V) for Treatment of Carbapenem-Resistant Enterobacteriaceae (CRE) Infections
  13. 302453
    “…Strategies to control transmission are critical. [Image: see text] DISCLOSURES: All authors: No reported disclosures.…”
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    512. Healthcare-Acquired (HA) Carbapenemase-Producing Enterobacteriales (CPE) in Southern Ontario, Canada: To Whom Are We Transmitting CPE?
  14. 302454
    “…Secretion of neurotrophic factors, including neurotrophin 3 (NT3), is one of the critical factors mediating BMSC neurological function recovery. …”
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    NT3(P75-2) gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model
  15. 302455
    “…This work highlights the influence of mechanical properties of the culture substrate on protein expression and the activity of drug metabolizing enzymes as a critical factor in developing accurate assay protocols for pharmacokinetic studies using primary intestinal cells. …”
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    Evaluation of human primary intestinal monolayers for drug metabolizing capabilities
  16. 302456
    “…Methodological quality was rated using the Joanna Briggs Institute Critical Appraisal Checklist for RCTs. RESULTS: Of 5140 studies retrieved, 10 fulfilled the inclusion criteria. …”
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    The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis
  17. 302457
    “…The virtual community facilitated access to all professionals caring for the critically ill and was characterized by a positive and collegial online culture. …”
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    Why Health Care Professionals Belong to an Intensive Care Virtual Community: Qualitative Study
  18. 302458
    “…The principal safety endpoint of fatal bleeding or bleeding into a critical space, occurred at a similar rate on rivaroxaban and placebo (0.44 events vs. 0.55 events per 100 patient-years). …”
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    A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial
  19. 302459
    “…BACKGROUND: Fecal metabolites are associated with gut visceral sensitivity, mucosal immune function and intestinal barrier function, all of which have critical roles in the pathogenesis of irritable bowel syndrome (IBS). …”
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    Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome
  20. 302460
    “…Many of these factors are difficult to address and extend beyond individual researchers to health systems and governmental policy, but understanding the burden of kidney disease is a critical first step to informing an integrated public health response that would provide appropriate screening, prevention and management of kidney disease in countries from SSA. …”
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    Methods and reporting of kidney function: a systematic review of studies from sub-Saharan Africa
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