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  1. 302801
    “…Alongside potential dating error caused by incomplete decontamination, proper consideration of sample association issues is required if we are ever to fully understand what happened with the human settlement of Iberia during these critical intervals, and especially so with regards to the fate of Iberia’s last Neandertal populations.…”
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    Revisiting the Middle and Upper Palaeolithic archaeology of Gruta do Caldeirão (Tomar, Portugal)
  2. 302802
    “…IMPORTANCE Accurate diagnostics for SARS-CoV-2 infections have been critical for responding to the COVID-19 pandemic. Both high-sensitivity/specificity PCR-based tests and lower-sensitivity/specificity rapid antigen assays have been the subject of worldwide supply chain limitations as individual facilities and countries have struggled to meet their population testing needs. …”
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    Molecular Mirror Technology Facilitates High-Throughput, Accurate SARS-CoV-2 Testing
  3. 302803
    “…Strong evidence suggests that endoplasmic reticulum stress plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through altered regulation of proteostasis. …”
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    The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial
  4. 302804
    por Goldbloom, Ellen, Lawrence, Sarah
    Publicado 2021
    “…The people, processes, and digital health adaptations required to support a primarily virtual mode of care were critical to its success.…”
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    41 Innovative solutions to support “Virtual First” pediatric endocrine care
  5. 302805
    “…N(6)-methyladenosine (m(6)A) RNA methylation plays critical roles in many immune and inflammatory diseases in livestock and other animals. …”
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    Comprehensive Analysis of Transcriptome-wide m(6)A Methylome Upon Clostridium perfringens Beta2 Toxin Exposure in Porcine Intestinal Epithelial Cells by m(6)A Sequencing
  6. 302806
    “…Primary VSgS was reserved to patients without significant intraventricular clots and critically ill patients that could not be transferred to the operating room and undergo a longer surgery. …”
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    Ventriculosubgaleal shunt and neuroendoscopic lavage: refining the treatment algorithm of neonatal post-hemorrhagic hydrocephalus
  7. 302807
    “…Background: Sepsis, as one of the severe diseases, is frequently observed in critically ill patients, especially concurrent with diabetes. …”
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    Admission Blood Glucose Is Associated With the 30-Days Mortality in Septic Patients: A Retrospective Cohort Study
  8. 302808
    “…It is important to look beyond the category of the technology (ie, patient portal) and consider its functionality (eg, data aggregation, appointment scheduling, messaging) to ensure that it aligns with the underlying strategic priorities of the deployment. It is also critical to establish a clear vision and ensure buy-ins from organizational leadership and health care providers to support a cultural shift that will enable a meaningful and widespread engagement.…”
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    Implementation Strategies to Improve Engagement With a Multi-Institutional Patient Portal: Multimethod Study
  9. 302809
    “…Our results for various BPSD suggest a critical window for timely intervention and care planning. …”
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    Factors Associated With Behavioral and Psychological Symptoms of Dementia: Prospective Observational Study Using Actigraphy
  10. 302810
    “…However, information on the mental health status of international medical students during this critical period of time has been scarce, which hinders the efforts in making proper policy or strategies to help these students. …”
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    Prevalence and Predictors of Anxiety and Depressive Symptoms Among International Medical Students in China During COVID-19 Pandemic
  11. 302811
    “…Nitrogen (N) deficiency is one of the critical environmental factors that induce leaf senescence, and its incidence may curtail leaf photosynthetic function and markedly alter the genetic information of plants that might result in low grain yield. …”
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    Nitrogen deficiency regulates premature senescence by modulating flag leaf function, ROS homeostasis, and intercellular sugar concentration in rice during grain filling
  12. 302812
    “…SIMPLE SUMMARY: Total sulfur amino acids play a critical role in numerous biological functions, including antioxidative status and immunity, as well as protein synthesis. …”
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    Optimal Standardized Ileal Digestible Total Sulfur Amino Acids to Lysine REQUIREMENTS Are Increased in Nursery Pigs Raised under Antibiotic-Free Feeding Regime
  13. 302813
    “…Nevertheless, other tissues and organs are also known to be critically affected following infection, thereby complicating the overall aetiology and prognosis. …”
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    Insights into COVID-19 Vaccine Development Based on Immunogenic Structural Proteins of SARS-CoV-2, Host Immune Responses, and Herd Immunity
  14. 302814
    “…Over the last two decades, many studies have demonstrated the critical role of the tumor microenvironment in tumorigenesis, progression, prognosis, and response to chemotherapy. …”
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    High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival
  15. 302815
    “…INTERPRETATION: The decision-make process is a critical problem mainly when it involves environmental and health control policies. …”
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    Fire association with respiratory disease and COVID-19 complications in the State of Pará, Brazil
  16. 302816
    “…IgA is the predominant antibody isotype at intestinal mucosae, where it plays a critical role in homeostasis and provides a first line of immune protection. …”
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    Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
  17. 302817
    “…Understanding the route and kinetics of infection, sites of colonization, and mechanisms of host inflammatory response is critical to reducing preterm birth risk. OBJECTIVES: This study developed an animal model of ascending infection and preterm birth with live bacteria (E. coli) in pregnant CD-1 mice with the goal of better understanding the process of microbial invasion of the intraamniotic cavity and intraamniotic inflammation. …”
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    Development of a mouse model of ascending infection and preterm birth
  18. 302818
    “…The expressions of RIPK1, RIPK3, MLKL, p-MLKL were detected as critical target genes of necroptosis and the potential therapeutic target compounds of Xiaoyaosan. …”
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    Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis
  19. 302819
    “…Exclusion/ subtraction of one of the following compounds: i-butyric acid, i-valeric acid, n-octanal, n-nonanal, n-decanal, n-dodecanal, undecanal or n-tridecanal, from each blend led to reduction in the attractiveness of all the resulting blends, suggesting that all of them are critical/important for the attractiveness of the foot odor to An. gambiae mosquitoes. …”
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    Semiochemical signatures associated with differential attraction of Anopheles gambiae to human feet
  20. 302820
    “…METHODS: We conducted a prospective pilot study among critically ill children prescribed VAN for clinical care. …”
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    1104. Comparison of Antibiotic Sampling Techniques: Predicting Plasma Vancomycin Concentrations Using Volumetric Absorptive Microsampling (VAMS) from Capillary and Venous/Arterial Whole Blood
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