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  1. 302901
    “…CONCLUSIONS: Outcome metrics that non-invasively measure the qualities of scar are critical for HTS research to evaluate treatment effectiveness. …”
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    609 Available non-invasive skin probes distinguish between normal skin and hypertrophic scar but not laser-treated scar
  2. 302902
    “…An unexpected event occurred when a mission-critical tower for the city’s grid toppled into a river resulting in delays for restoration of the grid, and city-wide boil-water and burn-ban policies. …”
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    543 Challenges in Burn Nurse and Therapy Staffing During and After a Category 4 Hurricane
  3. 302903
    “…Poly (ADP-ribose) polymerase 1 (PARP1) is a critical factor for DNA repair, and using PARP inhibitor (PARPi) is one of the promising treatments for BRCA-mutated (BRCA mut) tumors where homologous recombination repair is impaired due to BRCA1 mutation. …”
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    Combining Carbon-Ion Irradiation and PARP Inhibitor, Olaparib Efficiently Kills BRCA1-Mutated Triple-Negative Breast Cancer Cells
  4. 302904
    “…The CMA was accomplished with three critical conditions in place: (1) the two intervention delivery modalities (ie, online and staff) held intervention content constant; (2) families were randomized to the two parenting interventions; and (3) the online-delivered intervention was previously confirmed to be non-inferior to the staff-delivered intervention in significantly reducing the primary outcome, child disruptive behavior problems. …”
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    Online-Delivered Over Staff-Delivered Parenting Intervention for Young Children With Disruptive Behavior Problems: Cost-Minimization Analysis
  5. 302905
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    Outcomes in Temporary ICUs Versus Conventional ICUs: An Observational Cohort of Mechanically Ventilated Patients With COVID-19–Induced Acute Respiratory Distress Syndrome
  6. 302906
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    In Situ Pulmonary Thrombolysis and Perfusion Lung Angiography in Severe COVID-19 Respiratory Failure
  7. 302907
    “…With the ever-increasing societal dependence on electricity, one of the critical tasks in power supply is maintaining the power line infrastructure. …”
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    Design Knowledge for Deep-Learning-Enabled Image-Based Decision Support Systems: Evidence From Power Line Maintenance Decision-Making
  8. 302908
    “…BACKGROUND: Given the interrelated health of children and parents, strategies to promote stress regulation are critically important in the family context. However, the uptake of preventive mental health is limited among parents owing to competing family demands. …”
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    Digital Prompts to Increase Engagement With the Headspace App and for Stress Regulation Among Parents: Feasibility Study
  9. 302909
    “…Furthermore, we show that the conserved 3S sequence of gp41, known to bind to the innate sensor gC1qR, increases PLA2G1B activity in a gC1qR-dependent manner using gC1qR KO cells. The critical role of the 3S motif and gC1qR in the inhibition of CD4 T-cell function by the PLA2G1B/cofactor system in HIV-infected patients led us to screen additional microbial proteins for 3S-like motifs and to study other proteins known to bind to the gC1qR to further investigate the role of the PLA2G1B/cofactor system in other infectious diseases and carcinogenesis. …”
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    Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy
  10. 302910
    “…The rate ratios were highest in patients with critical covid-19 and highest during the first pandemic wave in Sweden compared with the second and third waves. …”
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    Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study
  11. 302911
    “…CONCLUSION: Despite pre-LT critical illness, intraoperative challenges, and prolonged post-LT recovery, LT appears feasible for carefully selected patients with irreversible C19 ARDS.…”
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    Lung Transplantation for COVID-19-Induced Respiratory Failure: Single-Center Case Series
  12. 302912
    “…Gram staining can potentially ameliorate the multidrug-resistant organisms in the critical care setting. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03506113…”
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    Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial
  13. 302913
    “…Timely rehabilitation has critical importance in force readiness. There remains debate about optimal treatment of Achilles tendon ruptures. …”
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    No Difference in Return to Duty Between Minimally Invasive, Percutaneous Achilles Tendon Repair and Nonoperative Functional Rehabilitation in Active Duty Military Members
  14. 302914
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    Prognostic Accuracy of Presepsis and Intrasepsis Characteristics for Prediction of Cardiovascular Events After a Sepsis Hospitalization
  15. 302915
    “…Most of the hospitalized critical COVID-19 patients manifested neurological signs and symptoms and higher mortality. …”
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    Acute Neurological Manifestations of COVID-19 Patients From Three Tertiary Care Hospitals in Qatar
  16. 302916
    por Zhang, Xiuao, Wu, Zhengcun, Ma, Kaili
    Publicado 2022
    “…BACKGROUND: The SNCA gene is a critical gene in Parkinson’s disease (PD) pathology. …”
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    SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma
  17. 302917
    “…Introduction A preliminary assessment of patients who suffer from severe and complex coronary artery lesions, such as three-vessel disease and/or a left main (LM) artery lesion, plays a critical contribution in determining prognosis and treatment plans for non-ST-segment elevation acute coronary syndrome (NSTE-ACS). …”
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    A Comparison Between Two-Dimensional and Three-Dimensional Regional and Global Longitudinal Strain Echocardiography to Evaluate Complex Coronary Lesions in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome
  18. 302918
    “…A 2-mm margin was used for PTV expansion, reduced to 0 mm at the interface with critical OARs. All plans fulfilled D(mean) ≥45 Gy. …”
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    Urethra Sparing With Target Motion Mitigation in Dose-Escalated Extreme Hypofractionated Prostate Cancer Radiotherapy: 7-Year Results From a Phase II Study
  19. 302919
    “…Understanding their information needs will be critical, as these needs vary with the use case, highlighting the importance of prioritizing and tailoring information to enable meaningful consent.…”
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    Foundations for Meaningful Consent in Canada’s Digital Health Ecosystem: Retrospective Study
  20. 302920
    “…In this period, press releases regarding critical events of the pandemic progression and government decisions on containment measures were followed by a utilization peak, irrespective of the sense (ie, positive or negative) of the information. …”
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    A Web-Based App for Emotional Management During the COVID-19 Pandemic: Platform Development and Retrospective Analysis of its Use Throughout Two Waves of the Outbreak in Spain
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