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  1. 303001
    “…Challenges in motor function are largely related to handling heterogeneous systems, such as dispensing solids or performing extractions. As a result, it is critical to understand that adapting experimental procedures that were designed for human experimenters is not as simple as transferring those same actions to an automated system, and there may be more efficient ways to achieve the same goal in an automated fashion. …”
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    Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab
  2. 303002
    “…Background: The disruption of joint homeostasis is a critical event during the process of joint injury in osteoarthritis (OA). …”
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    Extracellular Vesicle-Mediated miR-150-3p Delivery in Joint Homeostasis: A Potential Treatment for Osteoarthritis?
  3. 303003
    “…SIMPLE SUMMARY: Selection of molecular markers used in the marker-assisted selection of the litter size of sheep is critically essential. In this study, we identified single nucleotide polymorphisms (SNPs), g.51537A>G in SMAD5 and g.319C>T in SMAD7, from Tibetan sheep, and they were genotyped. …”
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    Molecular Characterization, Expression Profiles of SMAD4, SMAD5 and SMAD7 Genes and Lack of Association with Litter Size in Tibetan Sheep
  4. 303004
    “…Conclusion: FAM-related genes play critical roles in STAD prognosis by shaping the TIME. …”
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    Classification of stomach adenocarcinoma based on fatty acid metabolism-related genes frofiling
  5. 303005
    “…Across many sectors of health, investigators have explored digital health solutions to mitigate demand and extend the reach of professional practice beyond traditional clinical settings. OBJECTIVE: This critical appraisal and pilot feasibility study examines heart rate variability (HRV) biofeedback as an approach to help young people with ASD to manage anxiety symptoms outside of formal settings. …”
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    Heart Rate Variability Biofeedback to Treat Anxiety in Young People With Autism Spectrum Disorder: Findings From a Home-Based Pilot Study
  6. 303006
    “…Significant health benefits are expected if the optimistic 1.5°C goal is achieved, suggesting that carbon neutrality by mid-century is a critical target for China's sustainable development. …”
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    Projections of heatwave-attributable mortality under climate change and future population scenarios in China
  7. 303007
    “…Trehalose ameliorated autophagy impairments in icU1-KO hearts but did not delay cardiac dysfunction suggesting that ULK1 plays other critical, autophagy-independent, functions in the adult heart. …”
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    Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function
  8. 303008
    “…Both the neonates were COVID-19 positive. Eleven women with critical illness succumbed to the disease. No neonate was found to have early-onset SAR-CoV-2 infection during the first and third waves. …”
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    Maternal-Fetal Characteristics of Pregnant Women With Severe COVID Disease and Maternal-Neonatal Characteristics of Neonates With Early-Onset SARS-CoV-2 Infection: A Prospective Data Analysis
  9. 303009
    “…The cleavage site facilitates the entry of the virus into human cells via cell–cell fusion. This critical involvement of furin in the disease pathogenicity has made it a viable therapeutic strategy against the virus. …”
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    Consensus docking and MM-PBSA computations identify putative furin protease inhibitors for developing potential therapeutics against COVID-19
  10. 303010
    “…Based on the discovery of ORF4b-UBR5, a critical molecular target, further increasing the degradation of ORF4b caused by UBR5 could provide a new strategy for the clinical development of drugs for MERS-CoV.…”
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    UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b
  11. 303011
    “…Recent studies have revealed the critical role of TP53 gene in cancer immunology. Loss or mutation of p53 in cancer cells has been found to promote their immune escape. …”
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    Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy
  12. 303012
    “…Characterizing persistent malaria transmission that occurs after the combined deployment of indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) is critical to guide malaria control and elimination efforts. …”
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    Overlaying human and mosquito behavioral data to estimate residual exposure to host-seeking mosquitoes and the protection of bednets in a malaria elimination setting where indoor residual spraying and nets were deployed together
  13. 303013
    “…According to the ROC results, TIMP1, LOX, CD276, IFNA1, TLR2, and POSTN were considered to play a more critical role in malignant papillary thyroid cancer or immature cancer of papillary thyroid cancer. …”
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    Identifying key genes of classic papillary thyroid cancer in women aged more than 55 years old using bioinformatics analysis
  14. 303014
    “…BACKGROUND: Alcohol consumption is a critical driver of the HIV epidemic worldwide, particularly in sub-Saharan Africa, where unhealthy alcohol use and HIV are prevalent. …”
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    Digital Health Screening in People With HIV in Uganda to Increase Alcohol Use Reporting: Qualitative Study on the Development and Testing of the Self-administered Digital Screener for Health
  15. 303015
    “…Provision of psychological support from professionals and support groups is also critical during the process of testing and transfer. …”
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    Exploration of decision-making regarding the transfer of mosaic embryos following preimplantation genetic testing: a qualitative study
  16. 303016
    “…Noradrenergic terminals loss plays a critical role in RBD and was shown to exceed locus coeruleus pathology in PD using 11C-MeNER PET. …”
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    Molecular Imaging in Parkinsonian Disorders—What’s New and Hot?
  17. 303017
    “…CONCLUSION: For being a region of the Triple Frontier, there are many differences in political, administrative, and operational between the Public Health Systems of the three countries, with Paraguay and Argentina, the political-administrative-operational centralization is configured as a great node critical for the development of health actions in an adequate way to the needs at a loco-regional level and, above all, on time for the implementation thereof. …”
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    P464 Feline sporotrichosis: an emerging disease in the Brazilian side of the Southern Triple Border
  18. 303018
    “…POSTER SESSION 2, SEPTEMBER 22, 2022, 12:30 PM - 1:30 PM:   OBJECTIVE: Patients affected by trauma who get admitted to critical care units experience prolonged hospitalization and thereby acquire several infections. …”
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    P222 Epidemiology of Candida emia at level-1 trauma care cent er in North India
  19. 303019
    “…Early diagnosis and initiation of the appropriate treatment were critical for a successful outcome in keratitis cases, despite moderately high MICs of the antifungals used.…”
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    P185 Epidemiology of human fusariosis in Greece: results from a 16-year nationwide multicenter survey
  20. 303020
    “…Inflammatory immune cell infiltration is a central part of the pathogenesis of AAA. It’s critical to investigate the molecular mechanisms underlying immune infiltration in early-stage AAA and look for a viable AAA marker. …”
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    Identification of key monocytes/macrophages related gene set of the early-stage abdominal aortic aneurysm by integrated bioinformatics analysis and experimental validation
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