“…With these complaints he was admitted and put on prolonged fasting, after 6 hours of fasting his blood glucose levels dropped to 42mg/dl. His critical sample revealed RBS- 42mg/dl, C peptide -15.7ng/ml (reference range 0.9-7.1ng/ml), serum insulin >300 µIU/ml (1.9-23µIU/ml fasting state) and serum cortisol 20.65 ug/dl(5-25ug/dl). …”
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“…Most patients inevitably succumb to the wide-spread metastasis because of the lack of effective systemic treatment options or to complications from uncontrolled hypercortisolism. Therefore, it is critically important to identify new effective treatments that can be readily used in a clinical trial. …”
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“…Therefore, studying resistance to endocrine therapy is critical for breast cancer research.We have shown that invasive lobular breast cancer (ILC) cells resistant to the anti-estrogen tamoxifen increase their expression of metabotropic glutamate receptors (GRMs/mGluRs). …”
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“…This suggests that SRC family members are involved in signaling pathways critical for cancer cell proliferation and tumorigenesis. …”
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“…CONCLUSION: Clinicians should be aware of the risk of developing severe hypocalcemia in patients who are calcium dependent or vitamin D deficient, malnourished during critical illness, or have COVID-19 infection which may decrease serum albumin and reduce total serum calcium level. …”
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“…We then synthesized critical content from the thematic analysis of the data into four domains: clinician perceptions of prediction models and alerts; previous experiences of clinician encounters with predictive information and risk scores; desired characteristics of a CDS system build, including predictions, supporting information, and delivery methods for a potential alert; and the clinical relevance and potential utility of a CDS system. …”
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“…BACKGROUND: High-resolution soil moisture estimates are critical for planning water management and assessing environmental quality. …”
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“…OBJECTIVES: Although critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed. …”
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“…OBJECTIVE: This study aimed to identify, synthesize, and critically appraise the effectiveness of technology interventions improving social connectedness in older adults by assessing the quality of reviews, common observations, and derivable themes. …”
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“…The Joanna Briggs Institute quality assessment tool was used to critically appraise the methodological quality of studies. …”
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“…BACKGROUND: Annual retinal exams for patients with diabetes are critical as diabetic retinopathy is the number one cause of preventable blindness in working-age adults in the United States. …”
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“…The paper describes lessons learned regarding the critical role of early-phase testing prior to moving to a randomized trial. …”
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“…The selected papers were assessed for quality using the Cochrane Collaboration tool, National Institute for Health and Care Excellence clinical guidelines, Critical Appraisal Skills Programme Qualitative Checklist, and McGill University Mixed Methods Appraisal Tool. …”
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“…The model exhibited excellent diagnostic values (AUC > 0.85) in multiple datasets and multiple points in time and superiorly distinguished sepsis from other critical illnesses. ARG classifier showed significant correlations with clinical characteristics or endotypes and performed better in predicting mortality (AUC = 0.70) than other clinical characteristics. …”
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“…This selected group of patients may be candidates for CPI combined with modern radiotherapy techniques, such as intensity-modulated image-guided radiotherapy (IM-IGRT), volumetric arc therapy (VMAT) or proton therapy if available, which allow for the sparing of critical structures, such as the salivary glands, oral cavity, cochlea, larynx and pharyngeal muscles, to improve the patients’ quality of life. …”
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“…Additionally, trends observed among patient disposition specific to the pandemic, such as increasing rates of patient admission, observation, and against medical advice (AMA) departure with decreasing rates of discharge and transfer, offer insight into the burden of upper extremity injuries on the healthcare system during this critical time. While upper extremity orthopedic injuries remained common through the pandemic, the early pandemic was associated with higher rates of hospital admission that normalized closer to pre-pandemic levels by 2021, which may herald a shift and return to pre-pandemic trends. …”
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“…We also conclude that developing more direct networks and converting desired and potential networks into direct networks in WASH service provision is critical for the success of WASH service delivery. …”
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“…We performed a systematic review of the known data on cellular autografts from the iliac crest, tibia, and calcaneus focusing on the total cells harvested from each site as well as the presence of the critically important osteogenic osteoprogenitor cells. …”
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“…Molecular markers scalable for clinical use are critical for the development of effective treatments and the design of clinical trials. …”
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“…CATEGORY: Trauma INTRODUCTION/PURPOSE: Medial and syndesmotic stability evaluation of isolated supination-external rotation fibula fractures (ISER) is critical to determine surgical conduct. However, there is no agreement on the best method to diagnose instability preoperatively. …”
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