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  1. 303261
    “…In summary, we observed upregulation of the CD163-HMOX1-HAMP axis in MC subtypes at chronic active lesion rims, suggesting haptoglobin-bound hemoglobin but not transferrin-bound iron as a critical source for MC-associated iron uptake in MS. …”
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    Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis
  2. 303262
    “…INTRODUCTION: Selecting and collecting data to support appropriate primary and secondary outcomes is a critical step in designing trials that can change clinical practice. …”
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    Exploring the perspectives of selectors and collecters of trial outcome data: an international qualitative study
  3. 303263
    “…CONCLUSIONS: CT radiomics nomogram could serve as a preoperative biomarker of intra-tumoral TLSs status, better than independent radiomics or clinical models; preoperative CT radiomics nomogram achieved accurate stratification for RFS of ICC patients, better than the postoperative pathologic TLSs status. CRITICAL RELEVANCE STATEMENT: The radiomics nomogram showed better performance in predicting TLSs than independent radiomics or clinical models and better prognosis stratification than postoperative pathologic TLSs status in ICC patients, which may facilitate identifying patients benefiting most from surgery and subsequent immunotherapy. …”
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    A CT-based radiomics approach to predict intra-tumoral tertiary lymphoid structures and recurrence of intrahepatic cholangiocarcinoma
  4. 303264
    “…CONCLUSION: The 5.0 T rFOV-DWI showed better overall image quality and improved SNR compared to 3.0 T rFOV-DWI, which holds clinical potential for identifying the abdominal abnormalities in routine practice. CRITICAL RELEVANCE STATEMENT: This study provided evidence that abdominal 5.0 Tesla reduced field of view diffusion-weighted imaging (5.0 T rFOV-DWI) exhibited enhanced image quality and higher SNR compared to its 3.0 Tesla counterparts, holding clinical promise for accurately visualizing abdominal abnormalities. …”
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    Higher field reduced FOV diffusion-weighted imaging for abdominal imaging at 5.0 Tesla: image quality evaluation compared with 3.0 Tesla
  5. 303265
    “…CONCLUSIONS: All recruitment methods contributed to significant portions of the enrolled cohort, suggesting that a multipronged approach was a critical and successful strategy in our study of LGBTQ+ veterans. …”
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    Recruiting Sexual and Gender Minority Veterans for Health Disparities Research: Recruitment Protocol of a Web-Based Prospective Cohort Study
  6. 303266
    “…INTRODUCTION: Vaccination is a critical tool for preventing coronavirus disease 2019 (COVID-19) and influenza illnesses. …”
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    Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults
  7. 303267
    “…BACKGROUND: BRAF non-V600 mutation occupies a relatively small but critical subset in colorectal cancer (CRC). However, little is known about the biological functions and impacts of BRAF class III mutation in CRC. …”
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    BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8(+) T cell infiltration in colorectal cancer
  8. 303268
    “…BACKGROUND: Early childhood life is critical for optimal development and is the foundation of future well-being. …”
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    Screening and determinant of suspected developmental delays among Egyptian preschool-aged children: a cross-sectional national community-based study
  9. 303269
    por Guo, Xiang, Luo, Lei, Long, Yuxiang, Teng, Pingying, Wei, Yuehong, Xie, Tian, Li, Li, Yin, Qingqing, Li, Ziyao, Wang, Yuji, He, Jiejun, Ji, Xiatian, Zhou, Huasheng, Zhang, Xiaofan, Chen, Shigang, Zhou, Yezhen, Xu, Kaihui, Liang, Guancong, Kuang, Haocheng, Gao, Yuting, Liu, Xiaohua, Luo, Luting, Ding, Lin, Li, Yiji, Liu, Zhuanzhuan, Zhou, Tengfei, Lai, Zetian, Su, Xinghua, Guo, Yuyan, Li, Chenying, Xie, Lihua, Li, Minqing, Wu, Xinglong, Huang, Jianhao, Su, Weicong, Pan, Yicheng, Hu, Wei, Zhou, Dongrui, Li, Chunv, Gui, Juan, Ma, Jiazhi, Feng, Xiaoli, Zhu, Minyi, Zhong, Shangbin, Chen, Fan, Zeng, Huanchao, Wu, Yingxian, Wang, Chen, Li, Shukai, Wang, Qi, Wang, Xueyi, Zhou, Yekai, Ling, Jianxun, Liu, Yingjie, Wu, Shang, Li, Zhiwei, Zhong, Minghui, Wei, Wenxia, Xie, Lixian, Xu, Xianli, Huang, Hehai, Yang, Guilan, Liu, Yan, Liang, Siting, Wu, Yingxia, Zhang, Deyu, Xu, Changqing, Wang, Jie, Wang, Chunmei, Wu, Rangke, Yang, Zhicong, Chen, Xiao-Guang, Zhou, Xiaohong
    Publicado 2023
    “…Habitat management remains a critical factor for establishing a cost-effective systematic strategy for sustainable vector control. …”
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    Field investigation combined with modeling uncovers the ecological heterogeneity of Aedes albopictus habitats for strategically improving systematic management during urbanization
  10. 303270
    “…CONCLUSIONS: This study identifies lnc-MLETA1 as a critical exosomal lncRNA that mediates crosstalk in lung cancer cells to promote cancer metastasis and may serve as a prognostic biomarker and potential therapeutic target for lung cancer diagnosis and treatment. …”
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    Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer
  11. 303271
    “…BACKGROUND: The safe disposal of unused medication is a critical public health issue, with risks including environmental pollution, accidental ingestion, and misuse. …”
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    Drug take-back program: assessment of knowledge, practices, and barriers to safe disposal of unused medication among healthcare students in a Nigerian university
  12. 303272
    “…BACKGROUND: Homogentisate phytyltransferase (HPT) is the critical enzyme for the biosynthesis of tocopherols (vitamin E), which are the major lipid-soluble antioxidants and help plants adapt to various stress conditions. …”
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    Transcriptional and protein structural characterization of homogentisate phytyltransferase genes in barley, wheat, and oat
  13. 303273
    “…To ensure rigor and achievement of specific implementation science competencies, it is critical to systematically evaluate training programs. …”
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    Evaluation of a brief virtual implementation science training program: the Penn Implementation Science Institute
  14. 303274
    “…Decreased E484A fitness levels were over-compensated for by N501Y and Q498R, identifying a putative Omicron founder background that exceeds the intrinsic and effective fitness of WT and matches that of E484K. Critically, the E484A/Q498R/N501Y mutant and E484K have equal fitness also in presence of pre-Omicron vaccinee serum, whereas the fitness gain by E484K is lost in the presence of serum raised against the E484K variant in hamsters. …”
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    Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron
  15. 303275
    “…For TGW, mixed DCS and RS were the most frequent at85% (95% CI: 0.60–1.00; I(2)=91%) and online counseling at 84% (95% CI: 0.64–0.95) compared to other strategies. CONCLUSION: Critical issues play. Pivotal role in increasing PrEP awareness among MSM and TGW, minimizing access gaps, and ensuring retention of PrEP services. …”
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    Demand creation and retention strategies for oral pre-exposure prophylaxis for HIV prevention among men who have sex with men and transgender women: a systematic review and meta-analysis
  16. 303276
    “…Patients with pathologically confirmed or MRI model-predicted cholangiocyte phenotype HCC have a worse prognosis after hepatectomy. CRITICAL RELEVANCE STATEMENT: Four contrast-enhanced MRI features were significantly associated with cholangiocyte phenotype HCC and a worse prognosis following hepatectomy; these features may assist in predicting prognosis after surgery and improve personalized treatment decision-making. …”
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    Preoperative prediction of cholangiocyte phenotype hepatocellular carcinoma on contrast-enhanced MRI and the prognostic implication after hepatectomy
  17. 303277
    “…The scenario was based on acute asthma management graded on predefined critical actions using two scores: the checklist clinical score (range 0 to 30), and the team skills score (range 0 to 16). …”
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    Comparison of simulation and video-based training for acute asthma
  18. 303278
    “…This model facilitates identification of tsetse habitat and provides critical information to control tsetse, mitigate the impact of trypanosomiasis on vulnerable human and animal populations, and guide disease minimization in places with ephemeral tsetse. …”
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    A Bayesian maximum entropy model for predicting tsetse ecological distributions
  19. 303279
    “…BACKGROUND: Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC). …”
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    Protective effects of pyrroloquinoline quinone in brain folate deficiency
  20. 303280
    “…Growing evidence illustrates that lncRNAs play a critical role in CRC liver metastasis. Here we described a novel function and mechanisms of BACE1-AS promoting CRC liver metastasis. …”
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    m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling
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