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  1. 303281
    “…Inclusion was restricted to original studies published in English (or with English translation) reporting on endothelial dysfunction in critically ill human subjects undergoing resuscitation interventions. …”
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    Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis
  2. 303282
    “…METHODS: We evaluated six apheresis products from G-CSF-mobilized volunteer donors which were split automatically by the Prodigy, one portion each depleted of CD45RA(+) or of TCRαβ(+) and CD19(+) cells. We investigated critical quality attributes for both products. Products were assessed for recovery of HSPCs and mature subsets, as well as depletion efficiency of targeted cells using flow cytometry. …”
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    Automatic generation of alloreactivity-reduced donor lymphocytes and hematopoietic stem cells from the same mobilized apheresis product
  3. 303283
    “…Understanding inequities in trauma burden during times of stress is critical to directing resources and targeting intervention strategies. …”
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    Online Artículo Texto
    Relationship between the COVID-19 pandemic and structural inequalities within the pediatric trauma population
  4. 303284
    “…Scholars have uncovered a large number of exosomes that have been detected in follicular fluid, and exosomal miRNAs have been proven to play a critical role in controlling ovarian disorders and follicle formation. …”
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    Online Artículo Texto
    Specific expression profile of follicular fluid-derived exosomal microRNAs in patients with diminished ovarian reserve
  5. 303285
    “…BACKGROUND: N(6)-methyladenosine (m(6)A) mRNA modification plays a critical role in various human biological processes. …”
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    Online Artículo Texto
    Key m(6)A regulators mediated methylation modification pattern and immune infiltration characterization in hepatic ischemia-reperfusion injury
  6. 303286
    “…P. vivax expresses a Duffy binding protein (PvDBP) on merozoites, a DARC ligand, and the DARC: PvDBP interaction is critical for P. vivax blood stage malaria. Therefore, PvDBP is a leading vaccine candidate for P. vivax and a target for therapeutic human monoclonal antibodies (humAbs). …”
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    Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein
  7. 303287
    “…Dysregulation of the DNA replication licensing pathway, a critical step in growth control downstream of transduction signalling pathways, is associated with development of PCa. …”
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    Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer
  8. 303288
    “…Included papers were critically appraised using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement before data were extracted. …”
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    Online Artículo Texto
    Effectiveness and Cost-Effectiveness of eHealth Interventions in Somatic Diseases: A Systematic Review of Systematic Reviews and Meta-Analyses
  9. 303289
    “…The main feature of Interreality is a twofold link between the virtual and the real world achieved through experiential virtual scenarios (fully controlled by the therapist, used to learn coping skills and improve self-efficacy) with real-time monitoring and support (identifying critical situations and assessing clinical change) using advanced technologies (virtual worlds, wearable biosensors, and smartphones). …”
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    Online Artículo Texto
    Experiential Virtual Scenarios With Real-Time Monitoring (Interreality) for the Management of Psychological Stress: A Block Randomized Controlled Trial
  10. 303290
    “…However, a neglected area of research is the documentation and critical analysis of the formative research process required in the development and refinement of effective SMS messages. …”
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    Online Artículo Texto
    Unpacking the Black Box: A Formative Research Approach to the Development of Theory-Driven, Evidence-Based, and Culturally Safe Text Messages in Mobile Health Interventions
  11. 303291
    “…Participants in the intervention arm receive 10 video vignettes grounded in social learning and social cognitive theories that are designed to elicit critical thinking around issues of HIV transmission and disclosure. …”
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    Developing a Video-Based eHealth Intervention for HIV-Positive Gay, Bisexual, and Other Men Who Have Sex with Men: Study Protocol for a Randomized Controlled Trial
  12. 303292
    “…Improving health system efficiencies, particularly at the facility level, is an increasingly critical avenue for extending limited resources for ART; nevertheless, the potential impact of increased facility efficiency on ART capacity remains largely unknown. …”
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    The potential to expand antiretroviral therapy by improving health facility efficiency: evidence from Kenya, Uganda, and Zambia
  13. 303293
    “…BACKGROUND: The first minutes after birth are critical to reducing neonatal mortality. Helping Babies Breathe (HBB) is a simulation-based neonatal resuscitation program for low resource settings. …”
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    Online Artículo Texto
    Helping Babies Breathe (HBB) training: What happens to knowledge and skills over time?
  14. 303294
    “…Among the factors that determine the quality of life of cancer patients, pain has commonly been recognized as a most critical one; it could also lead to the ineffective treatment of the cancer. …”
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    Development and Testing of an Intelligent Pain Management System (IPMS) on Mobile Phones Through a Randomized Trial Among Chinese Cancer Patients: A New Approach in Cancer Pain Management
  15. 303295
    “…CONCLUSIONS: We have established a pan-European reference metabolome for urine and serum of healthy children and gathered critical resources not previously available for future investigations into the influence of the metabolome on child health. …”
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    Determinants of the urinary and serum metabolome in children from six European populations
  16. 303296
    “…Continued TES and monitoring of markers of resistance to artemisinin and partner drugs is critical for early detection of resistant parasites and to inform evidence-based malaria treatment policies. …”
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    Online Artículo Texto
    Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade of using artemisinin-based combination therapy in mainland Tanzania
  17. 303297
    “…Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. The aim of this study was to characterize ESBL-producing K. pneumoniae detected within and between two hospitals in uMgungundlovu district, South Africa, using whole genome sequencing (WGS). …”
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    Online Artículo Texto
    Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa
  18. 303298
    “…These data support the critical need for continued education and outreach on the risks of measles and the value of vaccination to prevent continued circulation in undervaccinated communities and potential further cases of severe disease. …”
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    LB15. Measles Outbreak in New York State (NYS) Outside of New York City, 2018–2019
  19. 303299
    “…IIV3-HD against homologous or drifted H3N2 viruses and similar responses to RIV4. qNIV may address several critical challenges confronting current egg-derived influenza vaccines, especially in the older adult population. …”
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    2753. Induction of Broadly Cross-Reactive Immune Responses Against A(H3N2) Airuses: Results of a Phase 2 Trial of a Novel Recombinant Hemagglutinin Saponin-Adjuvanted Nanoparticle Seasonal Influenza Vaccine
  20. 303300
    “…CONCLUSIONS: Studies such as Project DETECT are critical for evaluating POC HIV test devices as well as describing characteristics of persons at risk for HIV acquisition in the United States. …”
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    Online Artículo Texto
    Prospective Evaluation of HIV Testing Technologies in a Clinical Setting: Protocol for Project DETECT
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