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  1. 303301
    “…BACKGROUND: Growing evidence suggests that leptin is critical for glycemic control. Impaired leptin signaling may also contribute to low adiponectin expression in obese individuals. …”
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  2. 303302
    “…Type II diabetes mellitus (hsa04930) and PPAR signaling pathway (hsa03320) were confirmed as the critical pathways. CONCLUSIONS: These results improved current understanding of natural flavonoids on the treatment of T2D. …”
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  3. 303303
  4. 303304
    “…Gene ontology (GO) analysis was applied to elucidate biological processes and signaling pathways altered in APP/PS1 mice. Critical transcription factors were identified; alterations in chromatin accessibility were further confirmed using chromatin immunoprecipitation assays. …”
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  5. 303305
    “…Connective tissue growth factor (CTGF) is a critical factor in RA progression, which promotes fibroblast-like synoviocyte (FLS) proliferation, pannus formation, and the damage of cartilage as well as bone. …”
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  6. 303306
    “…By overexpression of chimeric Gα(qi) proteins in a model system, activation has been rescued, which identifies a critical role of the G protein status for cellular signaling. …”
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  7. 303307
    “…BACKGROUND: Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit life-saving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). …”
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  8. 303308
    “…This project will give hospital systems critical evidence-based tools for meeting National Hospital Quality Measures for tobacco treatment and maximizing their ability to improve cessation rates and overall health for the millions of smokers hospitalized annually in the US. …”
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  9. 303309
    “…By comparison, a large majority of the wheezing children age 3 to 18 years had striking atopic characteristics that may be critical as a risk factor for hospitalization and an adverse response to viral infections, especially infections caused by rhinovirus.…”
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  10. 303310
  11. 303311
    “…Despite the first 12 weeks being a critical time in the treatment pathway, limited research exists which examines how the transition onto dialysis impacts QOL. …”
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  12. 303312
    “…Video-mediated consultations are sometimes criticized for being not as good as face-to-face, but there has been little previous in-depth research on their interactional dynamics, and no agreement on what a good video consultation looks like. …”
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  13. 303313
    “…We collected detailed information on all urological procedures, stratified by disease, priority (higher vs lower), and patient setting (outpatient vs inpatient). Then, we critically discussed the implications of such recommendations for urology practice in both the forthcoming “adaptive” and the future “chronic” phase of the COVID-19 pandemic. …”
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  14. 303314
    “…BACKGROUND: GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. …”
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  15. 303315
    “…BACKGROUND: Advancing mental health among refugee and displaced adolescents and youth is critically important, as chronic psychological stress can have lifelong harmful impacts. …”
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  16. 303316
    por Chun, Tristen T., Judelson, Dejah R., Rigberg, David, Lawrence, Peter F., Cuff, Robert, Shalhub, Sherene, Wohlauer, Max, Abularrage, Christopher J., Anastasios, Papapetrou, Arya, Shipra, Aulivola, Bernadette, Baldwin, Melissa, Baril, Donald, Bechara, Carlos F., Beckerman, William E., Behrendt, Christian-Alexander, Benedetto, Filippo, Bennett, Lisa F., Charlton-Ouw, Kristofer M., Chawla, Amit, Chia, Matthew C., Cho, Sungsin, Choong, Andrew M.T.L., Chou, Elizabeth L., Christiana, Anastasiadou, Coscas, Raphael, De Caridi, Giovanni, Ellozy, Sharif, Etkin, Yana, Faries, Peter, Fung, Adrian T., Gonzalez, Andrew, Griffin, Claire L., Guidry, London, Gunawansa, Nalaka, Gwertzman, Gary, Han, Daniel K., Hicks, Caitlin W., Hinojosa, Carlos A., Hsiang, York, Ilonzo, Nicole, Jayakumar, Lalithapriya, Joh, Jin Hyun, Johnson, Adam P., Kabbani, Loay S., Keller, Melissa R., Khashram, Manar, Koleilat, Issam, Krueger, Bernard, Kumar, Akshay, Lee, Cheong Jun, Lee, Alice, Levy, Mark M., Lewis, C. Taylor, Lind, Benjamin, Lopez-Pena, Gabriel, Mohebali, Jahan, Molnar, Robert G., Morrissey, Nicholas J., Motaganahalli, Raghu L., Mouawad, Nicolas J., Newton, Daniel H., Ng, Jun Jie, O'Banion, Leigh Ann, Phair, John, Rancic, Zoran, Rao, Ajit, Ray, Hunter M., Rivera, Aksim G., Rodriguez, Limael, Sales, Clifford M., Salzman, Garrett, Sarfati, Mark, Savlania, Ajay, Schanzer, Andres, Sharafuddin, Mel J., Sheahan, Malachi, Siada, Sammy, Siracuse, Jeffrey J., Smith, Brigitte K., Smith, Matthew, Soh, Ina, Sorber, Rebecca, Sundaram, Varuna, Sundick, Scott, Tomita, Tadaki M., Trinidad, Bradley, Tsai, Shirling, Vouyouka, Ageliki G., Westin, Gregory G., Williams, Michael S., Wren, Sherry M., Yang, Jane K., Yi, Jeniann, Zhou, Wei, Zia, Saqib, Woo, Karen
    Publicado 2020
    “…OBJECTIVE: During the COVID-19 pandemic, central venous access line teams were implemented at many hospitals throughout the world to provide access for critically ill patients. The objective of this study was to describe the structure, practice patterns, and outcomes of these vascular access teams during the COVID-19 pandemic. …”
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  17. 303317
    “…Mononuclear cells such as helper T cells (CD4+), cytotoxic T cells (CD8+), and dendritic cells play a critical role in the initiation of the HPV-specific immune response and destruction of virus-infected cervical epithelial cells. …”
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  18. 303318
    “…The results of this large series of modern era national data may assist surgeons as well as patients and their families in making critical decisions in select cases of acutely complicated neoplastic disease.…”
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  19. 303319
  20. 303320
    “…CONCLUSIONS: Our study found, more than half of the survey children were in a critical health condition. Results suggest that child health improvements are dependent on multiple public health improvements, including providing better nutrition, promoting adequate hygiene behaviour, such as handwashing, keeping the latrines clean, keeping the household environment free from animal faeces and assuring a reliable supply of safe water.…”
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