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  1. 303461
    “…BACKGROUND: Wound management is a critical factor when treating patients with the inherited skin fragility disease dystrophic epidermolysis bullosa (DEB). …”
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    Impact of low-dose calcipotriol ointment on wound healing, pruritus and pain in patients with dystrophic epidermolysis bullosa: A randomized, double-blind, placebo-controlled trial
  2. 303462
    “…The FoxO transcription factors are reported to play critical roles in activating cardiomyocyte survival signaling throughout the process of cellular injuries induced by oxidative stress and are also involved in hypoxic postconditioning mediated neuroprotection, however, the role of FoxO in postconditioning mediated protection in the heart and in particular in high glucose condition is unknown. …”
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    Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
  3. 303463
    “…Yearly changes in all CVDs, IHD, cerebrovascular diseases and ACM mortality rates were insignificant prior to their respective critical year points in 2006, 2005, 2008 and 2007, but significantly decreased afterwards by an average of − 2.4% (95% CI -2.7, − 2.0%), − 1.6% (95% CI -2.1, − 1.1%), − 1.2% (95 CI -1.7, − 0.6%) and − 4.5% (95% CI -7.3, − 1.6%) among men, and by − 2.7% (95% CI -3.0, − 2.3%), − 2.0% (95% CI -2.6, − 1.4%), − 1.8% (95% CI 2.4, − 1.3%) and − 6.6% (95% CI -10.7, − 2.2%) among women, respectively. …”
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    Cardiovascular diseases mortality and alcohol control policy in Lithuania: exploring a possible link
  4. 303464
    “…These results underscore the need to better understand the contribution of modifiable environmental risk factors during potentially critical exposure periods. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12940-021-00807-x.…”
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    Prenatal ambient air pollution and maternal depression at 12 months postpartum in the MADRES pregnancy cohort
  5. 303465
    “…Although highly effective vaccines have been developed, non-pharmaceutical interventions remain critical to controlling disease transmission. One such intervention—rapid, at-home antigen self-testing—can ease the burden associated with facility-based testing programs and improve testing access in high-risk communities. …”
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    At-home testing to mitigate community transmission of SARS-CoV-2: protocol for a public health intervention with a nested prospective cohort study
  6. 303466
    por Souza, Gregory E, de Souza, Flávio Henrique Batista, Aguiar dos Reis, Marconi A, Dorim, Raoni A, Cristine Oliveira Gonçalves, Elisângela C, Floriano, Ana Luiza Silva, Tavares, Bruna de Souza, de Oliveira, André Magalhães, Ribeiro, Daniela Da Guarda, de Sá, Felipe Gonçalves, Lacerda, Júlia O, Caetano, Leandra Vieira, Augusto, Ludmila Rodrigues, Santos, Maria Luiza Costa, Viana, Otávio Reis, Soares, Alef Santos, de Medeiros, Felipe Ferreira, Figuereido, Amanda Luiza Alves, Calderón, Sergio Alfredo Hidalgo, Rojas Puell, María José, Quispe Chauca, Andrea del Carmen, Almeida, Maria Cristina, de Araújo, Arthur André Martins, Rodrigues, Artur Moreira, de Sá Rodrigues, Cátia Ribeiro, Morais, Jefferson Ricardo Rodrigues, Cardoso, Larissa Ludgero Soares, Colbert Câmara, Matheus Álvaro, Lopes, Pedro Alcântara Antunes, de Resende, Mateus Augusto Mendonça, de Oliveira, João Pedro Amaral, de Souza, Pedro Henrique Gonçalves, de Souza, Izadora Serdeira, Leal, Samara Soares, Aguiar, Mariana, de Faria, Maria Luiza Brandão, Ferreira, Paula G, Rocha, Leonora de Oliveira, Montes, Fernanda Luíza Pinheiro, Rocha, Luiz Felipe Oliveira
    Publicado 2021
    “…Game based learning surfaced as an effective alternative, since it promotes critical thinking and problem solving skills. A team of Brazilian and Peruvian students, physicians, designers and programmers gathered to create a decision based computer game that simulates a hospital scenario and allows medical students to analise, make decisions and receive feedback. …”
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    969. Gamification for Infectious Diseases Medical Education: Creating a Videogame to Teach COVID 19 Diagnosis and Treatment to Medical Students
  7. 303467
    “…BACKGROUND: The ability of oxidative enzyme-producing micro-organisms to efficiently valorize organic pollutants is critical in this context. Yeasts are promising enzyme producers with potential applications in waste management, while lipid accumulation offers significant bioenergy production opportunities. …”
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    Wood-feeding termite gut symbionts as an obscure yet promising source of novel manganese peroxidase-producing oleaginous yeasts intended for azo dye decolorization and biodiesel production
  8. 303468
    “…Endurance exercise training (ET) enhances insulin-mediated glucose metabolism, which plays a critical role in T2DM prevention and control. However, the combined effects of vitamin D supplementation and ET on IR in T2DM patients are unclear. …”
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    Combined effects of vitamin D supplementation and endurance exercise training on insulin resistance in newly diagnosed type 2 diabetes mellitus patients with vitamin D deficiency: study protocol for a randomized controlled trial
  9. 303469
    “…BACKGROUND: Sequential Organ Failure Assessment (SOFA) and other illness prognostic scores predict adverse outcomes in critical patients. Their validation as a decision-making tool in the emergency department (ED) of secondary hospitals is not well established. …”
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    Prognostic scores and early management of septic patients in the emergency department of a secondary hospital: results of a retrospective study
  10. 303470
    “…INTRODUCTION: As a building block of all health systems and a multi-sectoral domain, eHealth has a critical role to accelerate the achievement of sustainable development goals (SDGs), particularly universal health coverage (UHC). …”
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    Sixteen years of eHealth experiences in Iran: a qualitative content analysis of national policies
  11. 303471
    “…Individualized hemodynamic management requires advanced cardiac and brain monitoring in critically ill SAH patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13613-021-00960-z.…”
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    The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study
  12. 303472
    “…Two reviewers independently assessed articles before inclusion in the final review using the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) instrument for critical appraisal. The I(2) test was used to assess heterogeneity. …”
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    Prevalence and predictors of self-medication among university students in Ethiopia: a systematic review and meta-analysis
  13. 303473
    “…Thus, these results show DRD3-signalling in B cells as a critical regulator of CNS-autoimmunity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12974-021-02338-1.…”
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    Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity
  14. 303474
    por Suri, Jasjit S., Agarwal, Sushant, Carriero, Alessandro, Paschè, Alessio, Danna, Pietro S. C., Columbu, Marta, Saba, Luca, Viskovic, Klaudija, Mehmedović, Armin, Agarwal, Samriddhi, Gupta, Lakshya, Faa, Gavino, Singh, Inder M., Turk, Monika, Chadha, Paramjit S., Johri, Amer M., Khanna, Narendra N., Mavrogeni, Sophie, Laird, John R., Pareek, Gyan, Miner, Martin, Sobel, David W., Balestrieri, Antonella, Sfikakis, Petros P., Tsoulfas, George, Protogerou, Athanasios, Misra, Durga Prasanna, Agarwal, Vikas, Kitas, George D., Teji, Jagjit S., Al-Maini, Mustafa, Dhanjil, Surinder K., Nicolaides, Andrew, Sharma, Aditya, Rathore, Vijay, Fatemi, Mostafa, Alizad, Azra, Krishnan, Pudukode R., Nagy, Ferenc, Ruzsa, Zoltan, Gupta, Archna, Naidu, Subbaram, Paraskevas, Kosmas I., Kalra, Mannudeep K.
    Publicado 2021
    “…(1) Background: COVID-19 computed tomography (CT) lung segmentation is critical for COVID lung severity diagnosis. Earlier proposed approaches during 2020–2021 were semiautomated or automated but not accurate, user-friendly, and industry-standard benchmarked. …”
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    COVLIAS 1.0 vs. MedSeg: Artificial Intelligence-Based Comparative Study for Automated COVID-19 Computed Tomography Lung Segmentation in Italian and Croatian Cohorts
  15. 303475
    “…Multiparametric flow cytometry-based assays play a critical role in monitoring cellular manufacturing steps. …”
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    Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control
  16. 303476
    “…The presence of DM among COVID-19 patients significantly increased the risk of mortality, respiratory failure, duration of ventilator dependence, severe/critical COVID-19, ICU admission, and length of hospital stay.…”
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    The outcomes of patients with diabetes mellitus in The Philippine CORONA Study
  17. 303477
    “…We evaluated existing patient- and family-centered transitions in care tools and identified facilitators, barriers, and implementation considerations for the application of a transitions in care bundle in critically ill adults (i.e., a collection of evidence-based patient- and family-centred tools to improve outcomes during and after transitions from the intensive care unit [ICU] to hospital ward or community). …”
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    Co-development of a transitions in care bundle for patient transitions from the intensive care unit: a mixed-methods analysis of a stakeholder consensus meeting
  18. 303478
    “…We calculated sensitivity, specificity, and critical point of LDH, CEA and CYFRA21-1 between APAP patients and normal control group, and between grade 1–2 and 3–5 through receiving operating characteristics (ROC) curve. …”
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    CYFRA21-1 is a more sensitive biomarker to assess the severity of pulmonary alveolar proteinosis
  19. 303479
    “…BACKGROUND: Paternal lifestyle choices and male exposure history have a critical influence on the health and fitness of the next generation. …”
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    Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome
  20. 303480
    “…Anti-HBc IgM testing rates per 100,000 population were higher in females under 40 years of age and in males 40 years and above. CONCLUSION: Critical to hepatitis B elimination is strengthened infant vaccination coverage and interruption of vertical transmission. …”
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    Prevalence and incidence rates of laboratory-confirmed hepatitis B infection in South Africa, 2015 to 2019
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