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  1. 303481
    “…Therefore, Ig concentration in the colostrum and serum of dairy cows are critical traits when estimating the potential disease resistance of its offspring. …”
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    Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein
  2. 303482
    “…CONCLUSIONS: Oxygenation with a PaO(2) above 100 mmHg was independently associated with lower 90-day mortality, shorter ICU stay and intubation time in critically ill postsurgical sepsis/septic shock patients. …”
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    Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality
  3. 303483
    “…The endometrium plays a critical role in embryo implantation and pregnancy, and a thin uterus is recognized as a key factor in embryo implantation failure. …”
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    Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats
  4. 303484
    “…CONCLUSIONS: Our results suggest that the miR-133a/YES1 axis plays a critical role in cisplatin resistance in human ovarian cancer by regulating cell autophagy, which might serve as a promising therapeutic target for ovarian cancer chemotherapy treatment in the future. …”
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    miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy
  5. 303485
    “…BACKGROUND: Prediction of inpatients with community-acquired pneumonia (CAP) at high risk for severe adverse events (SAEs) requiring higher-intensity treatment is critical. However, evidence regarding prediction rules applicable to all patients with CAP including those with healthcare-associated pneumonia (HCAP) is limited. …”
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    A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study
  6. 303486
    “…Finding alternatives for these infections is critical, for which some neglected drugs may be an option. …”
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    Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial
  7. 303487
    “…Therefore, policymakers must facilitate the food promotional activities that are critical to enhancing the perceived benefits of organic food to combat issues like obesity. …”
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    Contrariwise obesity through organic food consumption in Malaysia: a signaling theory perspective
  8. 303488
    “…BACKGROUND: Compelling evidences demonstrated that gut microbiota dysbiosis plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). …”
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    Pediococcus pentosaceus CECT 8330 protects DSS-induced colitis and regulates the intestinal microbiota and immune responses in mice
  9. 303489
    “…In response to COVID-19 pandemic and overwhelmed hospital critical care and telemetry recourses, patch-based cardiac monitoring system received emergency Food and Drug Administration (FDA) approval for inpatient monitoring. …”
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    Arrhythmia patterns in patients with COVID-19 infection during and post hospitalization detected via a patch-based mobile cardiac telemetry system
  10. 303490
    “…One reviewer will extract data, with an independent review undertaken by the research team. Critical appraisal will depend on the nature of included evidence. …”
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    Transitions for older people with learning disabilities and behaviours that challenge others, and their family carers: a merged protocol for two rapid scoping reviews of evidence
  11. 303491
    “…BACKGROUND: Estrogen-related receptor α (ERRα) has been reported to play a critical role in endometrial cancer (EC) progression. …”
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    Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression
  12. 303492
    “…Most of the malaria cases presented at the emergency room (ER), only 3 required critical care. Only sex, hospitalized in-patient (IP) and attendance at ER were statistically associated with malaria. …”
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    A decade of travel-associated malaria at King Fahad Hospital of the University in the Eastern Province of Saudi Arabia
  13. 303493
    “…Non-adherence to personal protective equipment (PPE) or hand hygiene (n = 11), PPE shortage (n = 8) and high antibiotic use (n = 8) were most commonly reported as contributing factors, followed by environmental contamination (n = 7), prolonged critical illness (n = 7) and lack of trained HCW (n = 7). …”
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    The challenge of preventing and containing outbreaks of multidrug-resistant organisms and Candida auris during the coronavirus disease 2019 pandemic: report of a carbapenem-resistant Acinetobacter baumannii outbreak and a systematic review of the literature
  14. 303494
    “…CONCLUSIONS: A wide implementation of SR is of critical importance in order to offer referring physicians and patients optimum quality of service and to provide researchers with the best quality data in the context of big data exploitation of available clinical data. …”
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    Structured reporting of computed tomography in the staging of colon cancer: a Delphi consensus proposal
  15. 303495
    “…It has recently emerged as a critical risk factor in the pathophysiology of neuronal injuries and cerebral diseases. …”
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    TRPV4 contributes to ER stress and inflammation: implications for Parkinson’s disease
  16. 303496
    “…CONCLUSIONS: SUV39H1 plays a critical role in regulating corneal epithelial cell proliferation via H3K9me3-mediated suppression of p27 during CEWH. …”
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    SUV39H1 regulates corneal epithelial wound healing via H3K9me3-mediated repression of p27
  17. 303497
    “…CONTEXT: Asian elephant numbers are declining across much of their range driven largely by serious threats from land use change resulting in habitat loss and fragmentation. Myanmar, holding critical range for the species, is undergoing major developments due to recent sociopolitical changes. …”
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    Landscape characteristics influence ranging behavior of Asian elephants at the human-wildlands interface in Myanmar
  18. 303498
    “…We believe extracellular vesicles (EV) isolated from plasma are excellent candidates to fulfill this need. Because of the critical role BBB permeability plays in MS pathogenesis and identification of active disease, we sought to identify EV originating from central nervous system (CNS) endothelial as biomarkers of active MS. …”
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    CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis
  19. 303499
    “…Given that CSCC is a virus-induced malignancy, we hypothesized that the pattern recognition receptors (PRRs) involved in the innate immune response likely play a critical role in tumor development. METHODS: A bioinformatics analysis, qPCR, IHC, immunofluorescence, and WB were performed to determine the expression of NOD1/NOD2. …”
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    Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer
  20. 303500
    “…CONCLUSIONS: Our results demonstrate that IL-17A pretreatment could attenuate IFN-α-induced anti-HBV activity by upregulating negative regulators of the critical transcriptional ISGF3 complex. Thus, this might be a potential target for improving response to IFN-α therapy. …”
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    Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells
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