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  1. 303561
    “…Using the Dp(16)1Yey/+ (Dp16) mouse model for DS, which expresses three copies of Rcan1, we found reduced wheel running activity and rhythmicity in both light-entrained and free-running young Dp16 mice like young RCAN1-overexpressing mice. Critically, these diurnal and circadian deficits were rescued in part or entirely by restoring Rcan1 to two copies in Dp16 mice. …”
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    RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging
  2. 303562
    “…In our sample, the Horn of Africa was the most troubled area of arrival, with severe conditions frequently reported regarding skin diseases, in particular scabies. 2018 was the most critical year, especially for migrants from the Horn of Africa and Sub-Saharan Africa. …”
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    Health status assessment of a population of asylum seekers in Northern Italy
  3. 303563
    “…To satisfy the sizable requirement for clinical applications of hiPSCs, large-scale, expansion-oriented, xeno-free, and cost-effective media are critical. Although several xeno-free media for hiPSCs have been generated over the past decades, few of them are suitable for scalable expansion of cultured hiPSCs because of their modest potential for proliferation and high cost. …”
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    Development and evaluation of a novel xeno-free culture medium for human-induced pluripotent stem cells
  4. 303564
    por Duman, Murat, Şık, Nihan, Tekşam, Özlem, Akça, Halise, Kurt, Funda, Çağlar, Ayla Akca, Yıldız, Leman Akcan, Taşar, Medine Ayşin, Fidancı, İlknur, Yayla, Burcu Ceylan Cura, Yılmaz, Durgül, Güngör, Emre, Demir, Şule, Çokuğraş, Haluk, Cebeci, Sinem Oral, Önal, Pınar, Saz, Eylem Ulaş, Yurtseven, Ali, Uysalol, Metin, Yıldız, Raif, Gümüş, Süheyla, Bal, Alkan, Bayturan, Semra Şen, Zengin, Neslihan, Atik, Sinem, Çiftdoğan, Dilek Yılmaz, Berksoy, Emel, Çiçek, Alper, Şahin, Sabiha, Kızıl, Mahmut Can, Kara, Yalçın, Apa, Hurşit, Ulusoy, Emel, Kara, Aybüke Akaslan, Yesil, Edanur, Erdem, Meltem, Turan, Caner, Arslanoglu, Sertac, Duyu, Muhterem, Besli, Gulser Esen, Arslan, Gazi, Oflu, Ayşe Tolunay, Çeleğen, Mehmet, Buldu, Ebru, Pişkin, İbrahim Etem, Kardeş, Hakan, Yılmaz, Hayri Levent, Yıldızdaş, Dinçer, Gökulu, Gamze, Çay, Pınar, Özer, Utku, Güleryüz, Okşan Derinöz, Çolak, Özlem, Güneysu, Songül Tomar
    Publicado 2022
    “…In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). …”
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    COVID-19 Disease in Presenting to the Pediatric Emergency Department: A Multicenter Study of 8886 Cases
  5. 303565
    “…This detailed process evaluation is critical to inform further implementation and be considered alongside the effectiveness outcomes.…”
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    Telephone and Web-Based Delivery of Healthy Eating and Active Living Interventions for Parents of Children Aged 2 to 6 Years: Mixed Methods Process Evaluation of the Time for Healthy Habits Translation Trial
  6. 303566
    por Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T., Liang, Chun-chi, Lin, Karin, Astarita, Giuseppe, Khoury, Nathalie, Zuchero, Joy Yu, Thorne, Robert G., Shen, Kevin, Miller, Stephanie, Palop, Jorge J., Garceau, Dylan, Sasner, Michael, Whitesell, Jennifer D., Harris, Julie A., Hummel, Selina, Gnörich, Johannes, Wind, Karin, Kunze, Lea, Zatcepin, Artem, Brendel, Matthias, Willem, Michael, Haass, Christian, Barnett, Daniel, Zimmer, Till S., Orr, Anna G., Scearce-Levie, Kimberly, Lewcock, Joseph W., Di Paolo, Gilbert, Sanchez, Pascal E.
    Publicado 2022
    “…With mounting evidence of the role played by microglia in AD, high-dimensional approaches to phenotype microglia in those models are critical to refine our understanding of the immune response in the brain. …”
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    Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
  7. 303567
    “…VAP was associated with almost doubled ICU and hospital LOS and invasive mechanical ventilation, and increased mortality (RR 1.64 [1.02–2.65], p = 0.040) with no differences among patients' groups. CONCLUSIONS: Critically ill COVID-19 patients are at high risk for VAP, frequently caused by multidrug-resistant bacteria, and the risk is increased by corticosteroid treatment. …”
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    Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study
  8. 303568
    “…BACKGROUND: Elevated temperature and drought stress have substantial impacts on fruit quality, especially in terms of sugar metabolism and content. β-Amylase (BAM) plays a critical role in regulating jujube fruit sugar levels and abiotic stress response. …”
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    Genome-wide identification of BAM (β-amylase) gene family in jujube (Ziziphus jujuba Mill.) and expression in response to abiotic stress
  9. 303569
    “…Consideration of equity in policy is critical so that it can be translated into equitable services. …”
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    Equity consideration in palliative care policies, programs, and evaluation: an analysis of selected federal and South Australian documents
  10. 303570
    “…CONCLUSIONS: The current findings strongly supported that the DCLK1-S isoform may play a crucial role in the invasion, aggressive tumor behavior, and worsened survival outcomes of CRC patients. However, further critical investigations related to the potential preclinical and clinical utilities of DCLK1-S as a specific CRC-CSC marker are warranted. …”
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    Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: a systematic review and meta-analysis
  11. 303571
    “…Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and effective treatment strategies. …”
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    Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α
  12. 303572
    “…BACKGROUND: More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis. As a gatekeeper of mitochondria, the voltage-dependent anion channel 1 (VDAC1) is associated with the development of breast cancer (BC). …”
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    Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates
  13. 303573
    “…When prescribed to AD patients for their normal clinical indications, two of the apoE4 inhibitors, imipramine and olanzapine, but not other (non-hit) antipsychotic or antidepressant medications, were associated with improvements in cognition and clinical diagnosis, especially among APOE4 carriers. CONCLUSIONS: The critical test of any proposed AD mechanism is whether it leads to effective treatments. …”
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    Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
  14. 303574
    “…The transition period from Child and Adolescent Mental Health Services (CAMHS) to AMHS is a critical time, with a high risk of disengagement from healthcare. …”
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    Adult and child and adolescent psychiatrists' experiences of transition in anorexia nervosa: a qualitative study
  15. 303575
    “…There were 28,580 COVID-19-related hospital admissions, 1980 COVID-19-related critical care admissions and 6435 COVID-19-related deaths; corresponding IRs 4.77 (95% CI 4.74–4.80), 0.33 (95% CI 0.32–0.34) and 1.07 (95% CI 1.06–1.09), respectively. …”
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    Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY
  16. 303576
    “…Survival tended to improve over time, reflecting a greater critical volume of cases and multi-disciplinary care with early involvement of the respiratory team resulting in improved transitioning from PICU. …”
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    Outcomes of neonatal congenital diaphragmatic hernia in a non-ECMO center in a middle-income country: a retrospective cohort study
  17. 303577
    “…CONCLUSIONS: Our studies reveal that RNF133 is a testis-expressed E3 ubiquitin-protein ligase that plays a critical role for sperm function during spermiogenesis. …”
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    The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
  18. 303578
    “…Therefore, there is need to improve prediction of high-risk individuals, which is critical for efficient management of patients with NVAF. …”
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    A nomogram to predict left atrial appendage thrombus and spontaneous echo contrast in non-valvular atrial fibrillation patients
  19. 303579
    “…BACKGROUND: A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. …”
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    Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction
  20. 303580
    “…Risk of bias was assessed using the Critical Appraisal Skills Program (CASP) tools. A synthesis was performed using effect direct plots and charts to visualise effect sizes. …”
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    Environmental and practice factors associated with children’s device-measured physical activity and sedentary time in early childhood education and care centres: a systematic review
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