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  1. 303581
    “…BACKGROUND: Strategic implementation leadership is a critical determinant of successful implementation, hypothesized to create a more supportive implementation climate conducive to the adoption and use of evidence-based practices. …”
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    Online Artículo Texto
    Leading the charge in the education sector: development and validation of the School Implementation Leadership Scale (SILS)
  2. 303582
    “…BACKGROUND: Warning Labels (WL) highlight excessive amounts of critical nutrients in order to discourage consumption of unhealthful packaged food products. …”
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    Online Artículo Texto
    Objective understanding of front of pack warning labels among Mexican children of public elementary schools. A randomized experiment
  3. 303583
    “…BACKGROUND: Falls in older adults are a critical public health problem. As a means to assess fall risks, free-living digital biomarkers (FLDBs), including spatiotemporal gait measures, drawn from wearable inertial measurement unit (IMU) data have been investigated to identify those at high risk. …”
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    Online Artículo Texto
    Egocentric vision-based detection of surfaces: towards context-aware free-living digital biomarkers for gait and fall risk assessment
  4. 303584
    por Alam, Md. Zakiul, Islam, Md. Syful
    Publicado 2022
    “…BACKGROUND: Child health, especially childhood mortality, is one of the critical indicators of human development. No child mortality is desirable, but it is still high in Bangladesh. …”
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    Online Artículo Texto
    Is there any association between undesired children and health status of under-five children? Analysis of a nationally representative sample from Bangladesh
  5. 303585
    “…BACKGROUND: Financial risk protection (FRP), defined as households’ access to needed healthcare services without experiencing undue financial hardship, is a critical health systems target, particularly in low- and middle-income countries (LMICs). …”
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    Online Artículo Texto
    Financial risk protection from out-of-pocket health spending in low- and middle-income countries: a scoping review of the literature
  6. 303586
    “…Here, the lack of cancer-specific structures along with tumor heterogeneity represent a critical barrier to safety and efficacy. Modular CAR T cells indirectly binding the tumor antigen through CAR-adaptor molecules have the potential to reduce adverse events and to overcome antigen heterogeneity. …”
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    Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
  7. 303587
    “…Co-construction in research generates critical study design ideas through collective intelligence. …”
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    Online Artículo Texto
    Fantastic perspectives and where to find them: involving patients and citizens in digital health research
  8. 303588
    “…Microglia are important mediators of post-TBI neuroinflammation and critically impact TBI outcome. HDAC3 was reported to be essential to the inflammatory program of in vitro cultured macrophages, but its role in microglia and in the post-TBI brain has not been investigated in vivo. …”
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    Online Artículo Texto
    Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
  9. 303589
    “…BACKGROUND: Noninvasive ventilation (NIV) has been widely used in critically ill patients after extubation. However, NIV failure is associated with poor outcomes. …”
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    Online Artículo Texto
    Early prediction of noninvasive ventilation failure after extubation: development and validation of a machine-learning model
  10. 303590
    “…This paper summarises the company submission (CS), presents the ERG’s critical review of the clinical and cost-effectiveness evidence in the CS, highlights the key methodological considerations, and describes the development of the NICE guidance by the NICE Appraisal Committee. …”
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    Belimumab for Treating Active Autoantibody-Positive Systemic Lupus Erythematosus: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
  11. 303591
    “…BACKGROUND: Acute respiratory distress syndrome (ARDS) is a rapidly progressive and fatal respiratory failure disease that often occurs in critically ill patients. Since ARDS is associated with immune dysregulation and coagulation abnormalities, it is necessary to identify an appropriate predictor that can accurately predict ARDS mortality based on its pathophysiology. …”
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    Prognostic value of neutrophils to lymphocytes and platelets ratio for 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study
  12. 303592
    “…BACKGROUND: Functional capacity assessment is a critical step in the preoperative evaluation to identify patients at increased risk of cardiac complications and disability after major noncardiac surgery. …”
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    Smartphone-Based Gait Cadence to Identify Older Adults with Decreased Functional Capacity
  13. 303593
    “…BACKGROUND: A growing body of evidence suggests that T-cell responses against neoantigens are critical regulators of response to immune checkpoint blockade. …”
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    Single-cell analysis reveals clonally expanded tumor-associated CD57(+) CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
  14. 303594
    “…Here, we investigated whether biological response evaluated by ctDNA kinetics added critical information to the RECIST, and whether integrating on-treatment biological response information refined risk stratification of cancer patients. …”
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    Improving on-treatment risk stratification of cancer patients with refined response classification and integration of circulating tumor DNA kinetics
  15. 303595
    “…Few studies have examined differences in delirium severity between different populations of critically ill patients. The objective of the study was to compare delirium severity and the presence of the four core features between adults in the surgical intensive care unit (SICU) and medical intensive care unit (MICU) while controlling for variables known to be associated with delirium. …”
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    Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use
  16. 303596
    “…BACKGROUND: The first two weeks of post-hatch (PH) growth in broilers (meat-type birds) are critical for gut development and microbiota colonization. …”
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    Delayed access to feed early post-hatch affects the development and maturation of gastrointestinal tract microbiota in broiler chickens
  17. 303597
    “…This outcome suggests that counseling with couples, especially in critical life situations, can improve their relationship in the infertility treatment process and prevent emotional divorce and other negative impacts on their lives. …”
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    Investigating the effect of couple-centered counseling by Gottman method on the intimacy of infertile couples referring to the infertility Ward of Fatemieh hospital, Hamadan, Iran in 2020: a quasi-experimental study
  18. 303598
    “…Preliminary evidence suggests that including balance training and hospital versus home delivery may not be critical design elements for pre-operative TKR exercise interventions. …”
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    Content and delivery of pre-operative interventions for patients undergoing total knee replacement: a rapid review
  19. 303599
    “…Overall RoB was rated as serious/critical for 21 studies and as moderate for 2 studies. …”
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    Attributes in stated preference elicitation studies on colorectal cancer screening and their relative importance for decision-making among screenees: a systematic review
  20. 303600
    “…METHODS: In this study based on a well-characterized AD mouse model, we combined cell-specific laser capture microdissection and RNA-seq analysis to i) identify, without preconceived notions of the molecular and/or functional changes that would affect these cells, the genes and gene networks that are dysregulated in PAM or PCM at three critical stages of the disease, and ii) to investigate the potential contribution of both plaque-associated and plaque-distant microglia. …”
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    Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice
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