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  1. 303621
    “…The red wolf (Canis rufus) is a critically endangered wolf endemic to the eastern United States, where all extant red wolves are descended from 14 founders which has led to elevated levels of inbreeding over time. …”
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    Genetic diversity and family groups detected in a coyote population with red wolf ancestry on Galveston Island, Texas
  2. 303622
    “…TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing variant, is constitutively expressed in the stem cell-containing basal layer of stratified epithelial tissues, including the mammary gland, where it plays a critical role in stemness and tissue development. ΔNp63α has been reported to transcriptionally inhibit the tumour suppression protein p53. …”
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    ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response: ΔNp63α may cause genomic instability in epithelial stem cells
  3. 303623
    “…BACKGROUND: Previous studies have indicated that the ratio of lactate/albumin (L/A) has predictive value for the prognosis of critically ill patients with heart failure. Some studies have also indicated that a low serum bicarbonate concentration is inversely related to the mortality risk of patients with cardiogenic shock. …”
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    Association of lactate to albumin ratio and bicarbonate with short-term mortality risk in patients with acute myocardial infarction
  4. 303624
    por Riera, Jordi, Barbeta, Enric, Tormos, Adrián, Mellado-Artigas, Ricard, Ceccato, Adrián, Motos, Anna, Fernández-Barat, Laia, Ferrer, Ricard, García-Gasulla, Darío, Peñuelas, Oscar, Lorente, José Ángel, Menéndez, Rosario, Roca, Oriol, Palomeque, Andrea, Ferrando, Carlos, Solé-Violán, Jordi, Novo, Mariana, Boado, María Victoria, Tamayo, Luis, Estella, Ángel, Galban, Cristóbal, Trenado, Josep, Huerta, Arturo, Loza, Ana, Aguilera, Luciano, García Garmendia, José Luís, Barberà, Carme, Gumucio, Víctor, Socias, Lorenzo, Franco, Nieves, Valdivia, Luis Jorge, Vidal, Pablo, Sagredo, Víctor, Ruiz-García, Ángela Leonor, Martínez Varela, Ignacio, López, Juan, Pozo, Juan Carlos, Nieto, Maite, Gómez, José M., Blandino, Aaron, Valledor, Manuel, Bustamante-Munguira, Elena, Sánchez-Miralles, Ángel, Peñasco, Yhivian, Barberán, José, Ubeda, Alejandro, Amaya-Villar, Rosario, Martín, María Cruz, Jorge, Ruth, Caballero, Jesús, Marin, Judith, Añón, José Manuel, Suárez Sipmann, Fernando, Albaiceta, Guillermo M., Castellanos-Ortega, Álvaro, Adell-Serrano, Berta, Catalán, Mercedes, Martínez de la Gándara, Amalia, Ricart, Pilar, Carbajales, Cristina, Rodríguez, Alejandro, Díaz, Emili, de la Torre, Mari C., Gallego, Elena, Cantón-Bulnes, Luisa, Carbonell, Nieves, González, Jessica, de Gonzalo-Calvo, David, Barbé, Ferran, Torres, Antoni
    Publicado 2023
    “…BACKGROUND: The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. …”
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    Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis
  5. 303625
    “…Identifying gaps in knowledge and access to frontline workers who oversee these integrations is critical for understanding the potential for integrated social protection programming to improve these outcomes. …”
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    Knowledge of and access to frontline workers among poor, rural households in Amhara region, Ethiopia: a mixed-methods study
  6. 303626
    por Ma, Qi, Sun, Changjiao, Gao, Hong, Cai, Xu
    Publicado 2022
    “…Four predictors, the critical shoulder angle (CSA), the acromion index (AI), the greater tuberosity angle (GTA) and the double-circle radius ratio (DRR) were picked to participate in the present study. …”
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    The combined utilization of predictors seems more suitable to diagnose and predict rotator cuff tears
  7. 303627
    “…However, there remain critical knowledge gaps on the biology of An. balabacensis, such as life history data and life table parameters. …”
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    Life table analysis of Anopheles balabacensis, the primary vector of Plasmodium knowlesi in Sabah, Malaysia
  8. 303628
    “…Therefore, it is also critically important to identifying those patients who remain at high risk after H. pylori eradication therapy. …”
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    Potential association of eEF1A dimethylation at lysine 55 in the basal area of Helicobacter pylori-eradicated gastric mucosa with the risk of gastric cancer: a retrospective observational study
  9. 303629
    “…The evaluation of the three-day nutrition records revealed an unfavorable supply situation for numerous critical nutrients. More than half of the women (53.5%) had depleted iron stores (serum ferritin < 15 µg/l). …”
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    Nutritional and health status of adult Syrian refugees in the early years of asylum in Germany: a cross-sectional pilot study
  10. 303630
    “…METHODS: The EMBASE, PubMed, and Cochrane Library databases were used to find confocal laser scanning microscopy studies evaluating percentage and maximum depth of sealer penetration following the use of SI or CNI in mature permanent teeth until October 2022. The critical estimative checklist of randomized controlled trials of the standardized Joanna Briggs Institute was adopted to independently score the quality of each study. …”
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    Comparison of sealer penetration of sonic activation versus conventional needle irrigation: a systematic review and meta-analysis of randomized controlled trials
  11. 303631
    “…CONCLUSIONS: We demonstrate for the first time a critical role for HOTAIR and identify the involvement of the EGFR-ProT-NF-κB-HOTAIR signaling axis in cisplatin-induced cachexia in bladder cancer and likely other cancers. …”
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    Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer
  12. 303632
    “…BACKGROUND & AIMS: N(6)-methyladenosine (m(6)A) modification plays a critical role in progression of hepatocellular carcinoma (HCC), and aerobic glycolysis is a hallmark of cancer including HCC. …”
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    A functional loop between YTH domain family protein YTHDF3 mediated m(6)A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinoma
  13. 303633
    “…BACKGROUND: Burn is one of the critical health problems worldwide. Developing countries with sub-Saharan and Asian populations are affected more. …”
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    Outcome of burn injury and associated factor among patient visited at Addis Ababa burn, emergency and trauma hospital: a two years hospital-based cross-sectional study
  14. 303634
    “…Early innate immune response to HMPV is focused on induction of antiviral interferons (IFNs) and other pro-inflammatory cytokines that are critical for the formation of adaptive immune responses. …”
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    Profiles and predictive value of cytokines in children with human metapneumovirus pneumonia
  15. 303635
    por Tao, Xingguang, Yang, Qing
    Publicado 2022
    “…Demographics, radiological data, callus formation, union time, and functional outcomes were critically compared between the two groups. RESULTS: Thirty-seven patients were included in the present study according to our inclusion/exclusion criteria, of whom 16 (43.2%) were stratified into the CW group, and 21 (56.8%) into the IMN group. …”
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    Use of minimally invasive cerclage wiring for displaced major fragments of femoral shaft fractures after intramedullary nailing promotes bone union and a functional outcome
  16. 303636
    “…The course of the disease in hospitalised older patients may show significant variation, from mild to severe illness, ultimately leading to death in the most critical cases. The analysis of circulating biomolecules involved in mechanisms of inflammation, cell damage and innate immunity could lead to identify new biomarkers of COVID-19 severity, aimed to improve the clinical management of subjects at higher risk of severe outcomes. …”
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    Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients
  17. 303637
    “…BACKGROUND: The death of a partner is a critical life event in later life, which requires grief work as well as the development of a new perspective for the future. …”
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    A Web-Based Self-help Intervention for Coping With the Loss of a Partner: Protocol for Randomized Controlled Trials in 3 Countries
  18. 303638
    “…METHOD: Two reviewers (A.P., L.L.) independently screened and selected studies, extracted key findings and assessed methodological quality of included papers using Joanna Briggs Institute Checklist for Systematic Reviews and Research Synthesis, Joanna Briggs Institute Critical Appraisal Checklist for Text and Opinion Papers, Mixed Methods Appraisal Tool and International Centre for Allied Health Evidence Guideline Quality Checklist. …”
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    Spinal manipulation and mobilisation in the treatment of infants, children, and adolescents: a systematic scoping review
  19. 303639
    “…RESULTS: In this study, we aimed to clarify the molecular mechanisms of miR-194-5p, which has critical roles during PDAC progression. We found that the expression of miR-194-5p was significantly upregulated in PDAC tissue compared to tumor-adjacent tissue and was highly related to age and nerve invasion according to RNAscope and RT‒qPCR. …”
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    Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway
  20. 303640
    “…The CHA2DS2Vasc score classifies the risk of stroke in patients with atrial fibrillation, one of the most critical complications of this arrhythmia, and assists decision-making. …”
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    Big data analytics to depict patient journey: demographics, calculation and the relative role of the CHA2DS2Vasc score components in patients diagnosed with atrial fibrillation in a tertiary hospital
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