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  1. 303761
    “…The patient was managed with a multidisciplinary approach involving endocrinology, gastroenterology, and critical care teams. Her abdominal pain initially improved, followed by worsening around the sixth hospital day. …”
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    THU365 Diabetic Ketoacidosis Unmasking Acute Pancreatitis With A Hidden Surprise
  2. 303762
    “…These effects of Gipr silencing on the SU response were associated with changes in cellular ATP contents, which is critical to SU effects. Because diabetic condition had been reported to induce Vdac1 expression and subsequent ATP release in insulin-secreting cells(3)), we examined them with regard to Gipr silencing. …”
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    SAT062 Inhibition Of GIPR Expression Enhances Sulfonylurea-induced Insulin Secretion, And It Was Associated With Changes In ATP Contents
  3. 303763
    “…Reference: Shah A, Alhusayen R, Amini-Nik S. The critical role of macrophages in the pathogenesis of hidradenitis suppurativa. …”
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    THU366 Type 1 Diabetes Complicated By Multiple Episodes Of Diabetic Ketoacidosis Secondary To Flares Of Hidradenitis Suppurativa
  4. 303764
    “…Our data supports FOXA1 as a critical tumor intrinsic regulator of the TIME. This will have important implications on the design of immunotherapeutic approaches for late-stage PCa often with FOXA1 loss. …”
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    THU479 FOXA1 Loss Remodels The Tumor Immune Microenvironment In Late-stage Prostate Cancer
  5. 303765
    “…Such changes in these BBB components could indicate critical roles for the uniquely dense PVN vasculature, increasing risk of damage to neural functions that could include obesity, cardiovascular autonomic regulation, or depression-like behaviors. …”
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    THU124 High Fat Diet Disrupts Blood-Brain Barrier Integrity In Adult Males And Females
  6. 303766
    “…Previous studies have shown hypocalcemia was associated with higher mortality and worse outcomes in hospitalized and critically ill patients (PMID: 32533508). This study aims to compare the outcomes of patients admitted with COVID-19 with and without a secondary diagnosis of hypercalcemia. …”
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    THU401 Impact Of Hypercalcemia On Outcomes Among Patients Admitted With COVID-19
  7. 303767
    “…After 7 months of holding Keytruda, on routine blood work he had a critically low calcium level of 5.5 mg/dl (8.4-10.2 mg/dl) with tingling and numbness in his hands, muscle spasms, generalized weakness, and fatigue for the past few weeks. …”
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    SAT220 Rare Case Of Pembrolizumab Induced Primary Hypoparathyroidism
  8. 303768
    “…Spermatozoa have now been shown to carry key RNAs that may play critical roles in the development of the embryo. In this contest, a potential key growth regulator is insulin-like growth factor 2 (IGF2) whose gene is highly conserved and paternally imprinted. …”
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    FRI459 Sperm-Carried IGF2: Towards The Discovery Of The Spark That Gives Rise To Life
  9. 303769
    “…Introduction: The pulsatile release of the hypothalamic decapeptide, GnRH, activates signal transduction cascades in pituitary gonadotropes to control the synthesis and secretion of LH and FSH, hormones critical for normal reproductive function and fertility. …”
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    FRI286 Stimulation Of Egr1 Expression Is Mediated By A Gα(q/11)-signaling Pathway In A Pattern Distinct From That Of MEK/ERK At High And Low GnRH Pulse Frequencies
  10. 303770
    “…Therapy for HC can be complex, involves short- and long-term interventions, and correction is critical. Serum Ca surveillance before and during CTX management of cancer patients may reveal more instances and provide insight into the exact mechanisms. …”
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    SAT219 Severe Isolated Hypocalcemia With Cetuximab & Irinotecan Chemotherapy
  11. 303771
    “…These findings support a critical role of the APP-derived Aβ(1-42) in mediating tonic PTH secretion in the normal physiological state and suggest a new mechanism driving PTH hypersecretion in PHPT due to vitamin D deficiency. …”
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    OR23-01 The Nonredundant Role Of Beta-Amyloid In Mediating Tonic PTH Secretion In Physiological And Pathological States
  12. 303772
    “…This was managed with more aggressive insulin doses and a higher carbohydrate intake which played a critical role in correction of the insulin deficit and repletion of glycogen stores for metabolic recovery. …”
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    THU389 Euglycemic Diabetic Ketoacidosis With Prolonged Ketosis Due To SGLT-2 Inhibitor
  13. 303773
    “…As the maternal endocrine milieu can have critical effects on pregnancy outcomes and the programming of later onset diseases in offspring, it is important to study the impact of real-life EC exposure, i.e., chronic low levels of mixtures of ECs, in pregnant women. …”
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    OR06-01 Pre-conceptional And Gestational Exposure To A Real-life Environmental Chemical Mixture Increases Maternal Oxidative Stress And Disrupts The Cytokine Milieu In Sheep
  14. 303774
    “…Our study shows that referrals lack critical information which makes appropriate prioritization difficult. …”
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    THU250 Therapeutic Inertia In Primary Care With Poor Information Transfer To Specialist Care - A Rural Irish Experience
  15. 303775
    “…The data highlight the critical need for intervention approaches to mitigate these risks in nonbinary individuals. …”
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    SAT417 Comparison Of Mental Health Status In Transgender And Gender Diverse Versus Cisgender People
  16. 303776
    “…Severe hypercortisolism in the critically ill prompts the use of noninvasive evaluation tools and alternative medical approaches. …”
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    THU577 Acth Dependent Cushing Syndrome Identification And Management Challenges
  17. 303777
    “…As obesity is well known to be associated with multiple comorbidities, programs implementing early recognition and treatment are critical. While dietary counseling, behavioral therapy, and lifestyle changes are important components of obesity management, they are often not enough. …”
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    SAT681 Obesity Is A Disease. Maximize Positive Patient Outcome With Medical Treatment
  18. 303778
    “…Kisspeptin neurons are critical upstream regulators of GnRH neurons, relaying hormone feedback and potently activating GnRH secretion, but their role in PCOS remains incompletely understood. …”
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    FRI278 Kisspeptin Neuron Projections And Expression Patterns Are Unaltered In Prenatally Androgenized Female Mice Modeling PCOS
  19. 303779
    por Kubo, Hana, Laronda, Monica M
    Publicado 2023
    “…Therefore, we propose to differentiate hiPSCs into granulosa like cells (GLCs) that are functionally the same as granulosa cells (GCs), which are responsible for aromatizing androgens into estrogens. One factor critical to steroidogenesis in GCs is FOXL2, which in mice is suppressed by DKK1, a WNT inhibitor. …”
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    OR19-05 Human Induced Pluripotent Stem Cell-derived Granulosa-like Cells From Ligand-based Differentiation Express FOXL2 After Inhibition Of DKK1
  20. 303780
    “…Due to the fact that the root dentin surface continues to interact with the irrigating solution during preparation, it's critical to evaluate the mechanical characteristics and smear layer removal. …”
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    Comparative Evaluation of Microhardness, Smear Layer Removal Efficacy and Depth of Penetration Using Punica granatum, Emblica officinalis and Sodium Hypochlorite As Endodontic Irrigants: An In Vitro Study
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