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  1. 303821
    “…RESULTS: We provide a review of published approaches for predicting RNA-binding residues in proteins and a systematic comparison and critical assessment of protein-RNA interface residue predictors trained using these approaches on three carefully curated non-redundant datasets. …”
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    Protein-RNA interface residue prediction using machine learning: an assessment of the state of the art
  2. 303822
    “…However, adherence to the intervention seems critical for effectiveness. Finally, our results also suggest that more research is needed to assess the optimum intervention dose. …”
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    Preventing Smoking Relapse via Web-Based Computer-Tailored Feedback: A Randomized Controlled Trial
  3. 303823
    “…These data led us to test the hypothesis that σR1 may be critical in forestalling chronic retinal stress; diabetes was used as the model of chronic stress. …”
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    Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1
  4. 303824
    “…CONCLUSIONS: Pathology image algorithm validation and comparison are essential to iterative algorithm development and refinement. One critical component is the support for queries involving spatial predicates and comparisons. …”
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    A high-performance spatial database based approach for pathology imaging algorithm evaluation
  5. 303825
    “…We believe that well-designed user interfaces and rigorous quality control strategy for entity annotation and linking were critical to the success of this work. Second, as a further contribution to the Internet-based crowdsourcing field, we will publicly release the JavaScript and CrowdFlower Markup Language infrastructure code that is necessary to utilize CrowdFlower’s quality control and crowdsourcing interfaces for named entity annotations. …”
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    Web 2.0-Based Crowdsourcing for High-Quality Gold Standard Development in Clinical Natural Language Processing
  6. 303826
    “…Ongoing support will be critical to overcome these unique challenges to ensure continual disease monitoring as interventions to disrupt PA exposure are implemented in the community.…”
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    Evaluation of the Pyrrolizidine Alkaloid Induced Liver Disease (PAILD) Active Surveillance System in Tigray, Ethiopia
  7. 303827
    por Corley, Courtney D., Pullum, Laura
    Publicado 2013
    “…INTRODUCTION: One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information to decision makers, in order to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews [1,2]. …”
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    Disease Models for Event Prediction
  8. 303828
    por Munene, Esther, Mottice, S., Reid, J.
    Publicado 2013
    “…To implement effective prevention and treatment strategies, it is critical to conduct timely contact tracing and evaluate people who may have come into contact with an infected person. …”
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    Evaluating a Social Network Analytic Tool to Support Outbreak Management and Contact Tracing in an Outbreak of Pertussis
  9. 303829
    “…BACKGROUND: The diverse microbial populations that inhabit pristine aquifers are known to catalyze critical in situ biogeochemical reactions, yet little is known about how the structure and diversity of this subsurface community correlates with and impacts upon groundwater chemistry. …”
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    Functional microbial diversity explains groundwater chemistry in a pristine aquifer
  10. 303830
    “…Results of this trial will provide critically needed guidance for clinicians in a variety of health professions who prescribe and oversee treatment and prevention of OA-related complications. …”
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    Strength Training for Arthritis Trial (START): design and rationale
  11. 303831
    “…PURPOSE: Knowledge on the normative growth of the spine is critical in the prenatal detection of its abnormalities. …”
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    Morphometric study of the T6 vertebra and its three ossification centers in the human fetus
  12. 303832
    “…Three reviewers were involved in study selection, data extraction and critical appraisal. For the meta-analysis, data on total T, free T and SHBG were extracted and combined using random effects analysis. …”
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    The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis
  13. 303833
    “…The substantia gelatinosa (lamina II) of the spinal dorsal horn plays a critical role in nociceptive transmission. An activated spinal microglia, which is believed to release pro-inflammatory cytokines including TNF-α, plays an important role in the development of neuropathic pain, and CCL2 is a key mediator for spinal microglia activation. …”
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    Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons
  14. 303834
    “…CONCLUSIONS: The first 3 days of an epidemic is a critical period for the authorities to take appropriate action through Internet surveillance to prevent and control the epidemic, including preparation of personnel, technology, and other resources; information release; collection of public opinion and reaction; and clarification, prevention, and control of rumors. …”
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    Importance of Internet Surveillance in Public Health Emergency Control and Prevention: Evidence From a Digital Epidemiologic Study During Avian Influenza A H7N9 Outbreaks
  15. 303835
    “…In some instances, these highly-stressed departments were also departments with higher staff turnover, attributed most consistently to the acuity of patient care. The critical mass of acquired HeartMath mastery by more than one thousand employees allowed the organization to introduce HeartMath's neutral technique as a nonpharmacological option for patients experiencing pain, anxiety, or sleeplessness. …”
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    Sustained Hospital-based Wellness Program
  16. 303836
    “…While the S and A components have been widely implemented, evidence and specific targets are lacking for the F and E components, of which water, sanitation, and hygiene (WASH) are critical elements. Data on the impact of WASH on trachoma are needed to support policy and program recommendations. …”
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    Effect of Water, Sanitation, and Hygiene on the Prevention of Trachoma: A Systematic Review and Meta-Analysis
  17. 303837
    por Grabham, Peter, Sharma, Preety
    Publicado 2014
    “…The human vasculature is critical to healthy functioning of the tissues of the body and a major factor in maintaining homeostasis is the endothelial barrier. …”
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    Acute effects of ionizing radiation on human endothelial barrier function
  18. 303838
    por Rossignol, D A, Genuis, S J, Frye, R E
    Publicado 2014
    “…The findings of this review suggest that the etiology of ASD may involve, at least in a subset of children, complex interactions between genetic factors and certain environmental toxicants that may act synergistically or in parallel during critical periods of neurodevelopment, in a manner that increases the likelihood of developing ASD. …”
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    Environmental toxicants and autism spectrum disorders: a systematic review
  19. 303839
    “…However, accurately and reliably annotating (ie, extracting information from) photographs remains difficult, a critical bottleneck inhibiting the use of photographs for systematic surveillance. …”
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    Cameras for Public Health Surveillance: A Methods Protocol for Crowdsourced Annotation of Point-of-Sale Photographs
  20. 303840
    “…Accurate and timely pain assessment is critical to pain management. In particular, pain needs to be consistently tracked over time in order to gauge the effectiveness of different treatments. …”
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    Pain-QuILT: Clinical Feasibility of a Web-Based Visual Pain Assessment Tool in Adults With Chronic Pain
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