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  1. 303881
    “…Therefore, effective and cost-effective novel, digital apps that will effectively and safely support care management are critical and timely. To inform development of such an app for children with CKD, a user requirements-gathering exercise was first needed. …”
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    Desirable Components for a Customized, Home-Based, Digital Care-Management App for Children and Young People With Long-Term, Chronic Conditions: A Qualitative Exploration
  2. 303882
    “…Sensitivity analysis identified ErbB3 as the most critical activator of phosphoinositide 3-kinase (PI3K) and Akt signaling, a key pro-survival pathway in cancer cells. …”
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    Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
  3. 303883
    “…Aggrecanase-mediated aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of synovial tissues to produce ADAMTS family that play important roles in the degradation of articular cartilage, examining the influence of Hb by synovial cells in vitro experimental system. …”
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    Hemoglobin Stimulates the Expression of Adamts-5 and -9 by Synovial Cells; A Possible Cause of Cartilage Damage after Intra-articular Bleeding
  4. 303884
    “…Therefore, this study was designed to test the hypothesis that BMAC treatment of large femoral condylar OCAs would be associated with superior radiographic OCA bone integration compared to non-treated allografts during the critical first 6 months after surgery. METHODS: An IRB-approved review of patients enrolled in a prospective registry who were treated with large OCA transplants to one or both femoral condyles at our institution from March 12, 2013 to March 14, 2016 was performed. …”
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    Effects of Bone Marrow Aspirate Concentrate on Radiographic Integration of Femoral Condylar Osteochondral Allografts
  5. 303885
    “…Each of these PROs have been touted for specific advantages and criticized for certain limitations. In addition, clinical results documented for each of these PROs cannot be easily compared with those from other measures employed in patients undergoing different procedures in varying anatomic locations. …”
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    Correlation of PROMIS CAT with Validated Hip Outcome Scores in Patients Undergoing Hip Arthroscopy
  6. 303886
    por Bowman, Clive E.
    Publicado 2017
    “…Nomograms to diagnose the feeding state of P. longicornis in field samples are presented and show that the timing of these four phases in the wild could be inferred by scoring 10–12 mites out of a sample of 20. Suggestions to critically confirm or refute the conclusions are included.…”
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    Gut contents, digestive half-lives and feeding state prediction in the soil predatory mite Pergamasus longicornis (Mesostigmata: Parasitidae)
  7. 303887
    “…BACKGROUND: Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investigate the association of imaging features derived from the first follow-up computed tomography (CT) on lung cancer patient outcomes following SBRT, and identify patients at high risk of recurrence. …”
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    CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy
  8. 303888
    “…CONCLUSIONS: Taken together, our data show that maintaining GSH homeostasis is not only important for quenching OS in the developing fetal brain, but equally critical to enhance M2 like microglia phenotype, thus suppressing inflammatory responses elicited by environmental stressors. …”
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    Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress
  9. 303889
    “…BACKGROUND: Although HIV disease stage at ART initiation critically determines ART outcomes, few reports have longitudinally monitored this within Asia. …”
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    Ten year experience with antiretroviral treatment in Cambodia: Trends in patient characteristics and treatment outcomes
  10. 303890
    “…Two independent reviewers identified eligible reports and conducted critical appraisal (based on the Joanna Briggs Institute Qualitative Assessment and Review Instrument: JBI-QARI). …”
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    End User and Implementer Experiences of mHealth Technologies for Noncommunicable Chronic Disease Management in Young Adults: Systematic Review
  11. 303891
    “…Among new findings with the capacity to gain clinical relevance is the detection of overexpressed snoRNAs known to regulate some critical cellular functions as ribosome biogenesis. …”
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    Comprehensive molecular biomarker identification in breast cancer brain metastases
  12. 303892
    “…Our innovative approach integrates gene co-expression modules with biomolecular interaction network analysis to identify network modules critical to the PD pathway and disease mechanism. We quantify the positive effects of drugs in a DESS score that is based on known drug-target activity profiles. …”
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    Repositioning drugs by targeting network modules: a Parkinson’s disease case study
  13. 303893
    “…Adolescent girls and young women (AGYW) in the age range of 15 to 24 years are twice as likely as their male peers to be infected, making females in sub-Saharan Africa the most at-risk group for HIV infection. It is therefore critical to prioritize access to HIV testing, prevention, and treatment for this vulnerable population. …”
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    High-Yield HIV Testing, Facilitated Linkage to Care, and Prevention for Female Youth in Kenya (GIRLS Study): Implementation Science Protocol for a Priority Population
  14. 303894
    “…OBJECTIVES: This study investigated the inhibition of viable adhering bacteria on novel antimicrobially coated surgical sutures using chlorhexidine or octenidine, a critical factor for proliferation at the onset of local infections. …”
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    Viable adhered Staphylococcus aureus highly reduced on novel antimicrobial sutures using chlorhexidine and octenidine to avoid surgical site infection (SSI)
  15. 303895
    “…A better understanding of malaria parasite population diversity and transmission dynamics is critical for assessing the effectiveness of malaria control measures. …”
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    Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT
  16. 303896
    “…BACKGROUND: For people to be able to access, understand, and benefit from the increasing digitalization of health services, it is critical that services are provided in a way that meets the user’s needs, resources, and competence. …”
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    A Multidimensional Tool Based on the eHealth Literacy Framework: Development and Initial Validity Testing of the eHealth Literacy Questionnaire (eHLQ)
  17. 303897
    “…Support and guidance on how to use these tools would be critical to achieve these goals. OBJECTIVE: The objective of this study was to develop evidence-based guidance and support for the use of P3C-PRMs in health and social care policy through identification of PRMs that can be used to enhance the development of P3C, mapping P3C-PRMs against an existing model of domains of P3C, and integration and organization of the information in a user-friendly Web-based database. …”
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    Patient-Reported Measures for Person-Centered Coordinated Care: A Comparative Domain Map and Web-Based Compendium for Supporting Policy Development and Implementation
  18. 303898
    “…Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic areas. …”
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    Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
  19. 303899
    “…RESULTS: The RDT probe reactions detected most RRDR mutations tested, although we found a few critical discrepancies between observed results and manufacturers’ claims. …”
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    Potential Application of Digitally Linked Tuberculosis Diagnostics for Real-Time Surveillance of Drug-Resistant Tuberculosis Transmission: Validation and Analysis of Test Results
  20. 303900
    “…BACKGROUND: Controlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core—including acetylation, phosphorylation, crotonylation, propionylation, butyrylation, formylation, and citrullination—can alter the strong electrostatic interactions between the oppositely charged nucleosomal DNA and the histone proteins and thus modulate accessibility of the nucleosomal DNA, affecting processes that depend on access to the genetic information, such as transcription. …”
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    Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core
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