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  1. 303901
    “…BACKGROUND: Schizophrenia is a chronic severe mental illness affecting 0.4% of the society with its early age of onset (generally between 15–25 years) which can be seen in people from all social strata, has recurrent episodes or relapses, and causes disability by deteriorating interpersonal and occupational functioning. Critical behavioral findings accelerated the efforts on understanding the neurobiology of this complex disorder. …”
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    F161. BRAIN VOLUME CHANGE IN PATIENTS WITH SCHIZOPHRENIA AND ITS RELATION WITH ANTIPSYCHOTIC DRUG USE
  2. 303902
    “…With the dearth of available treatments for negative symptoms, levodopa augmentation may represent a novel pharmacologic strategy to address this critical unmet therapeutic need for schizophrenia.…”
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    F225. LEVODOPA AUGMENTATION OF ANTIPSYCHOTICS FOR THE TREATMENT OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA
  3. 303903
    “…BACKGROUND: Social functioning deficits are of critical importance in patients with schizophrenia, because they affect the long-term outcomes and quality of life (QOL) of the patients. …”
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    F238. COMPETENCE-PERFORMANCE DISCREPANCY IN SOCIAL FUNCTIONING IN PATIENTS WITH SCHIZOPHRENIA: THE IMPACT OF SOCIAL ANXIETY
  4. 303904
    por Marzullo, Giovanni
    Publicado 2018
    “…Also, in a study suggested by associations of CADs with artistic abilities, we found the SCZ-liability, GP1-coincident seasonality among groups representing visual, performing and literary art “creators” (VPL-Artists) and the SCZ-resistance, GP2-coincident seasonality among groups representing art critics, historians, curators and other art “observers” (Para-Artists). …”
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    T198. A SCHIZOPHRENIA-LIKE BIRTH SEASONALITY AMONG MATHEMATICIANS AND AN OPPOSITE SEASONALITY AMONG BIOLOGISTS: MORE EVIDENCE IMPLICATING BIMODAL RHYTHMS OF GENERAL BIRTHS
  5. 303905
    “…Consistent with previous reports, patient iPSC-neurons displayed reduced synaptic protein expression compared with healthy iPSC-neurons. Critically, when patient iPSC-neurons were treated with 17β-estradiol or raloxifene, we observed an increase in synaptic protein expression to a level similar to that observed in untreated healthy iPSC-neurons. …”
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    O10.7. INVESTIGATING THE MECHANISMS UNDERLYING THE BENEFICIAL EFFECTS OF ESTROGENS IN SCHIZOPHRENIA
  6. 303906
    “…From a behavioural perspective both reduced glutamate and enhanced dopamine levels are currently discussed as critical contributing factors to generate aberrant beliefs (glutamate) during information sampling and to generate confidence or expected precision (dopamine) during action selection. …”
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    S231. THE ROLE OF DOPAMINERGIC AND GLUTAMATERGIC NEUROTRANSMISSION IN DELUSIONAL IDEATION AND SENSORY INFORMATION PROCESSING OF PATIENTS WITH SCHIZOPHRENIA IN COMPARISON TO HEALTHY HUMAN PARTICIPANTS
  7. 303907
    “…These findings provide, to our knowledge, the first evidence that brain glutamate levels are associated with emotional hyper-responsivity and volumetric changes in HS in brain regions thought to be critical in the pathophysiology of psychotic symptoms. …”
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    O6.2. NEUROBIOLOGY OF PSYCHOMETRIC SCHIZOTYPY: INSIGHTS FROM MULTIMODAL IMAGING RESEARCH
  8. 303908
    “…Social cue processing, particularly face perception, plays a critical role in social cognitive functioning. Patients with schizophrenia struggle to extract information from faces and interpret facial expressions (Kohler et al., 2010). …”
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    F77. OXYTOCIN ENHANCES VISUAL ATTENTION TO FACIAL STIMULI IN PATIENTS WITH SCHIZOPHRENIA: EVIDENCE FROM AN EYE-TRACKING STUDY
  9. 303909
    “…BACKGROUND: Participating in groups are a critical part of rehabilitation model in Early Psychosis Intervention. …”
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    T254. IMPACT OF A DROP IN, OPEN ENDED, PSYCHO EDUCATIONAL GROUP ON CLIENT ENGAGEMENT IN AN EARLY PSYCHOSIS INTERVENTION PROGRAM
  10. 303910
    “…Furthermore, this study highlighted the fact that cell–cell interaction using multicellular ALI-models combined with an in vivo-like inhalation exposure system is critical in better mimicking the airway physiology compared with traditional cell culture systems. …”
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    Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization
  11. 303911
    “…Using ARQ 092 to target AKT, a critical node connecting PI3K and mTOR pathways, we observed the following: (1) strong anti-proliferative activity [ARQ 092 at 0.5, 1, and 2.5 μM blunted phosphorylation of AKT and its downstream targets (in the presence or absence of serum) and inhibited proliferation after 72 h; rapamycin at 100 nM did not decrease AKT phosphorylation] and (2) less cytotoxicity as compared to rapamycin and wortmannin. …”
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    In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS)
  12. 303912
    “…Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. …”
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    The Detroit Young Adult Asthma Project: Proposal for a Multicomponent Technology Intervention for African American Emerging Adults With Asthma
  13. 303913
    “…BACKGROUND: Computational modeling of cardiovascular flow is a growing and useful field, but such simulations usually require the researcher to guess the flow’s inlet and outlet conditions since they are difficult and expensive to measure. It is critical to determine the amount of uncertainty introduced by these assumptions in order to evaluate the degree to which cardiovascular flow simulations are accurate. …”
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    The effect of inlet and outlet boundary conditions in image-based CFD modeling of aortic flow
  14. 303914
    “…Although all necessary steps lead to a prolonged treatment duration, this may be applied in selected cases where high doses to adjacent OARs are regarded as critical.…”
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    Combined Inter- and Intrafractional Plan Adaptation Using Fraction Partitioning in Magnetic Resonance-guided Radiotherapy Delivery
  15. 303915
    “…We provide a brief review of functional regression analysis and examples that illustrate the methodology. We highlight critical elements of model specification: (i) type and number of basis functions, (ii) the degree of the polynomial, and (iii) the methods used to estimate regression coefficients. …”
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    Bayesian functional regression as an alternative statistical analysis of high-throughput phenotyping data of modern agriculture
  16. 303916
    “…BACKGROUND: Plasmodium falciparum is the most virulent parasite of the five Plasmodium species that cause human malaria, and biological analysis of the parasite is critical for the development of novel strategies for disease control. …”
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    Identification and characterization of DNA endonucleases in Plasmodium falciparum 3D7 clone
  17. 303917
    “…We previously reported that p62 (sequestosome-1) in bone marrow stromal cells (BMSC) is critical for the formation of MM-induced signaling complexes that mediate OB suppression. …”
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    XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression
  18. 303918
    “…BACKGROUND: Elucidating developmental trajectories of white matter (WM) microstructure is critically important for understanding normal development and regional vulnerabilities in several brain disorders. …”
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    Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease
  19. 303919
    “…Apoptosis and macroautophagy/autophagy play critical roles in PD pathogenesis; as such, modulating their balance is a potential treatment strategy. …”
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    Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
  20. 303920
    “…METHODS: The Healthcare Information and Management Systems Society (HIMSS) Analytics’ Electronic Medical Record Adoption Model (EMRAM) dataset was used to track historic uptakes of various electronic health record functionalities considered critical to improving health care quality and efficiency in hospitals. …”
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    Forecasting the Maturation of Electronic Health Record Functions Among US Hospitals: Retrospective Analysis and Predictive Model
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