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  1. 304001
    “…Jak2 is a promiscuous kinase whose oncogenic actions are well-characterized, while Stat5a is a transcription factor whose activities are critical in attenuating the oncogenicity of Jak2. Following PRL stimulation, it was observed that hPRLrL/I co-expression induced approximately two-fold greater Jak2-Y1007/1008 phosphorylation (pJak2) compared to that induced by hPRLrL expression alone. …”
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    SAT-130 The Intermediate Prolactin Receptor Is a Breast Cancer Oncogene
  2. 304002
    “…The first 14 days of life were a critical period and nutrition is known to be mandatory to promote newborns’ growth (Asbury 2019). …”
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    SAT-103 Extrauterine Growth Restriction (EUGR) in Preterm Infants: Incidence, Risk Factors, Nutrition, Auxological and Neurological Outcome.A Retrospective Study from 2010 to 2016
  3. 304003
    “…Our work underscores the critical role that the HNF4α isoforms play in the metabolic switch, and suggests that the kidney as well as the liver could be involved.…”
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    SUN-LB119 Role of HNF4a Isoforms in the Carbohydrate/Lipid Switch in the Liver and Responsiveness to AMPK
  4. 304004
    “…Current treatments for type 2 diabetes (T2D) and obesity do not reliably achieve long-term weight-loss and up to 50% of patients experience nausea and vomiting. Thus, there is a critical need for obesity medications that provide glycemic control with enhanced hypophagic response without nausea. …”
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    SUN-660 Appetite Suppressing Effects of Glucoregulatory Chimeric Peptides Devoid of Nausea
  5. 304005
    “…Thus, we propose that one of the critical actions of androgens in regulating follicular function and female fertility is through the regulation of JMJD3 expression.…”
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    OR31-04 Androgen Signaling Regulates Female Fertility Through Modulation of H3K27me3 in Granulosa Cells
  6. 304006
    “…Sufficient nutrition is critical for reproduction. We have previously shown that leptin, a circulating indicator of fat stores, signals to pituitary gonadotropes to maintain gonadotropin releasing hormone receptor (GnRHR) protein levels in female mice. …”
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    SAT-292 Musashi: A Novel Regulator of the Gonadotrope Transcriptome
  7. 304007
    “…Conclusion: Our case highlights the importance of surgical management as an effective cure for parathyroid crisis and underscores the associated critical and significant rise in calcium and PTH levels, which was resistant to medical treatment.…”
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    MON-370 Treatment of Parathyroid Storm in a Patient with Traumatic Brain Injury: A Reversible Comatose State
  8. 304008
    “…Taken together, our data have identified multiple factors, including inhibition of FoxO1 and activation of GATA4-Nkx2.5, that can drive ex vivo human EE cell differentiation, with unique hormone production profiles, when targeted via small molecules. This is a critical first step towards understanding the role of enteroendocrine cells in disease and the development of EE cell-based therapies.…”
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    MON-726 Modifications of FOXO1 and GATA4-NKX2.5 Signaling Induce Human Enteroendocrine Differentiation
  9. 304009
    “…The effect of mild induced hypothermia on outcomes of patients after cardiac arrest: a systematic review and meta-analysis of randomized controlled trials. Zhang et al. Critical Care (2015) 19:417. 2. Therapeutic hypothermia for acute brain injuries. …”
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    AN ASSESSMENT OF CLINICAL EFFICACY OF HYPOTHERMIC THERAPY FOLLOWING MILD TRAUMATIC BRAIN INJURY IN THE ADOLESCENT ATHLETE AS COMPARED TO AN UNTREATED ACTIVE CONTROL POPULATION
  10. 304010
    “…A comprehensive classification system is critical to advance LDM research from single-center, level 4 studies to prospective multicenter efforts that will enhance improve communication, research, and evidence-based treatment of LDM pathology.…”
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    INTEROBSERVER RELIABILITY OF A COMPREHENSIVE LATERAL DISCOID MENISCUS CLASSIFICATION SYSTEM: A MULTICENTER ARTHROSCOPIC VIDEO ANALYSIS STUDY
  11. 304011
    “…These observations are critical in understanding how our micro- and macro-level environments can influence cognitive performance…”
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    S68. DIFFERENTIAL PATTERN OF SOCIAL COGNITION IMPAIRMENT BETWEEN RURAL AND URBAN DWELLING PATIENTS OF SCHIZOPHRENIA AND ITS FUNCTIONAL CORRELATES
  12. 304012
    “…The fact that early response was found to be a strong predictor of PS remission supports early and adequate symptom control for which medication is a critical issue. Further research applying data-driven trajectory analysis in FEP is warranted to facilitate better characterization of longer-term patterns of remission and development of targeted intervention to promote early recovery.…”
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    O3.5. EARLY TRAJECTORIES OF POSITIVE SYMPTOMS REMISSION IN FIRST EPISODE-PSYCHOSIS: A 2-YEAR FOLLOW-UP STUDY
  13. 304013
    “…Development of systematic incentive strategies to encourage regular aerobic exercise will be critical to successful dissemination of exercise programs as part of the treatment of schizophrenia.…”
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    O4.1. AEROBIC EXERCISE DOSE DETERMINES THE COGNITIVE GAIN IN FIRST-EPISODE SCHIZOPHRENIA, SO HOW DO WE ENCOURAGE SUFFICIENT EXERCISE?
  14. 304014
    “…Because CSS-M scores have been shown to predict recidivism, it is critical to further understand the foundation of these negative attitudes towards the criminal justice system to prevent the continued over-representation of people with serious mental illness in the criminal justice system.…”
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    M242. PREDICTORS OF CRIMINAL SENTIMENTS SCALE (CSS-M) SCORES AMONG OUTPATIENTS WITH PSYCHOTIC DISORDERS
  15. 304015
    “…The left STG may be a critical target for postmortem and neuromodulation studies in schizophrenia studies.…”
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    S165. GLUTAMATERGIC ABNORMALITIES IN EARLY SCHIZOPHRENIA AND BIPOLAR DISORDER MEASURED USING WHOLE-BRAIN SPECTROSCOPY
  16. 304016
    “…Results: Among the 37 patients, five had mild disease, 30 had moderate disease, one had severe disease, and one was critically ill. All of the patients were released from quarantine, and no mortality was observed. …”
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    Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China
  17. 304017
    “…MAIN OUTCOME MEASURES: Admission to critical care (high dependency unit or intensive care unit) and mortality in hospital. …”
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    Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study
  18. 304018
    “…CONCLUSIONS: Digital HIV care navigation fills a critical gap in public health and HIV care systems, making these systems more responsive and accountable to the needs of the most vulnerable individuals. …”
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    Efficacy and Impact of Digital HIV Care Navigation in Young People Living With HIV in San Francisco, California: Prospective Study
  19. 304019
    “…In general, based on existing data published to date, 80.9% of patients infected with the virus develop mild infection; 13.8% severe pneumonia; 4.7% respiratory failure, septic shock or multi-organ failure; 3% of these cases are fatal. Critical patients have been shown to develop acute respiratory distress syndrome (ARDS) and hospitalization in intensive care units. …”
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    A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application()()
  20. 304020
    “…CONCLUSIONS: The findings of this study will provide the critical next step in delivering early alcohol interventions to the youth, capitalizing on social media platforms, which could have significant public health impact by altering alcohol use trajectories of adolescents and emerging adults engaged in risky drinking. …”
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    Social Media Interventions for Risky Drinking Among Adolescents and Emerging Adults: Protocol for a Randomized Controlled Trial
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