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  1. 304481
    “…BACKGROUND: Medication adherence plays a critical role in controlling the evolution of chronic disease, as low medication adherence may lead to worse health outcomes, higher mortality, and morbidity. …”
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    Psychometric Properties of a Machine Learning–Based Patient-Reported Outcome Measure on Medication Adherence: Single-Center, Cross-Sectional, Observational Study
  2. 304482
    “…CONCLUSION: This study could potentially pave the way for groundbreaking insights into the relationship between SIRI and stroke patient outcomes, as it appears to be the first meta-analysis to explore this association. Given the critical role of the inflammatory response in stroke recovery, closely monitoring patients with high SIRI levels could represent a promising strategy for mitigating brain damage post-stroke. …”
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    Systemic inflammation response index as a clinical outcome evaluating tool and prognostic indicator for hospitalized stroke patients: a systematic review and meta-analysis
  3. 304483
    “…Moreover, the 81–120 amino acid (aa) region of NSP6 is critical for autophagy induction and STING1 degradation. …”
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    SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1
  4. 304484
    “…Moreover, the ruminal microorganisms’ homeostasis is a guarantee of beef steers’ growth and health. The most critical period for newly received cattle is the first-month post-transport. …”
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    Revealing the developmental characterization of rumen microbiome and its host in newly received cattle during receiving period contributes to formulating precise nutritional strategies
  5. 304485
    “…The mean LA50 values showed significant improvements following significant modifications in our critical care for burn victims, including augmented intensive care unit capacity, prompt relocation of inhalation burn cases to the intensive care unit, establishing a well-trained multidisciplinary team, and improved infection control. …”
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    Cohort analysis of 50% lethal area (LA50) and associating factors in burn patients based on quality improvements and health policies
  6. 304486
    “…Limited absolute cell yield due to low sample weight must be considered in early cell culture passages and might be critical for the range of clinical applications possible for BM-MSCs from this source. …”
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    Bone marrow from periacetabular osteotomies as a novel source for human mesenchymal stromal cells
  7. 304487
    “…These novel insights are critical to guide AD clinical trial design and research.…”
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    APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
  8. 304488
    “…Lastly, intercellular communication network analysis unveiled the critical roles of activated ECs, mesenchymal transitioning ECs, protomyofibroblasts, and VSMCs in upregulating signaling pathways associated with cellular proliferation (MDK, PDGF, VEGF), transdifferentiation (Notch), migration (ephrin, semaphorin), ECM remodeling (collagen, laminin, fibronectin), and inflammation (thrombospondin), following distension. …”
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    Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation
  9. 304489
    “…With additional prospective and external validation, such a model may assist risk assessment and optimize clinical decision-making in choosing the best care plan during the critical stages of COVID-19.…”
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    A Hybrid Decision Tree and Deep Learning Approach Combining Medical Imaging and Electronic Medical Records to Predict Intubation Among Hospitalized Patients With COVID-19: Algorithm Development and Validation
  10. 304490
    “…BACKGROUND: The prevalence of Acinetobacter baumannii in nosocomial infections and its remarkable ability to develop antimicrobial resistance have been a critical issue in hospital settings. Here, we examined the genomic features related to resistance phenotype displayed by carbapenem-resistant A. baumannii (CRAB) MTC1106 (ST2) and MTC0619 (ST25). …”
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    Comparative genotypic characterization related to antibiotic resistance phenotypes of clinical carbapenem-resistant Acinetobacter baumannii MTC1106 (ST2) and MTC0619 (ST25)
  11. 304491
    “…CONCLUSION: Weakly supervised segmentation is a viable approach by which explainable object detection models may be developed for medical imaging. CRITICAL RELEVANCE STATEMENT: WSUnet learns to segment images at voxel level, training only with image-level labels. …”
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    Weakly supervised segmentation models as explainable radiological classifiers for lung tumour detection on CT images
  12. 304492
    “…Removing the heaviest piglets from the litter for a short period during suckling (split-suckling) may allow the smallest and less viable piglets to have access to the udder during the critical initial hours after farrowing. This experiment has shown that mortality is not altered by split-suckling. …”
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    Short- and Long-Term Effects of Split-Suckling in Pigs According to Birth Weight
  13. 304493
    “…In this study, we explored a critical lncRNA, LOC339059, that can predict the clinical prognosis in GC related to the modulation of PD-L1 and determined its influence upon macrophage polarization via the IL-6/STAT3 pathway. …”
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    Long Non-Coding RNA LOC339059 Attenuates IL-6/STAT3-Signaling-Mediated PDL1 Expression and Macrophage M2 Polarization by Interacting with c-Myc in Gastric Cancer
  14. 304494
    “…SIMPLE SUMMARY: Acquired resistance of gastrointestinal stromal tumors (GISTs) to imatinib mesylate (IM) is one of the most critical challenges in GIST therapy. Here we show that a long-term culture of GIST T-1 cells with IM induces clonal heterogeneity resulting in the appearance of cancer cells exhibiting activation of the FGFR-signaling pathway which was associated with KIT loss. …”
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    Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations
  15. 304495
    “…The results demonstrated that the novel_circ_000838-ame-miR-6000a-3p axis may plays a critical regulatory part in the larval gut development and immunity. …”
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    Novel Insights into the circRNA-Modulated Developmental Mechanism of Western Honey Bee Larval Guts
  16. 304496
    “…CONCLUSION: The collection of NF-GNB pathogens tested in this study have been designated serious threats, so accurate AST results are critical for diagnostic stewardship. VITEK 2 EA/CA rates were > 90% for most of ATMs tested against this challenging collection of NF-GNB; however, β-lactam agents showed CA rates < 88% against PSA (80% of discordances were minor errors). …”
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    568. Evaluation of the VITEK 2 XL Antimicrobial Susceptibility Testing for Non-fermenter Gram-Negative Bacilli: The Importance of Continuing to Monitor AST Systems
  17. 304497
    “…[Figure: see text] [Figure: see text] CONCLUSION: These data demonstrate that, among US PWH on stable oral ART, switching to long-acting ART resulted in significantly higher adherence and persistence, a critical aspect of long-term success of HIV treatment, compared with remaining on oral ART. …”
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    1024. Real-world Adherence and Persistence with Long-Acting Cabotegravir Plus Rilpivirine (CAB+RPV LA) Compared to Oral Antiretroviral Therapy (ART) Among People with HIV (PWH) in the US: The ABOVE Study
  18. 304498
    “…BACKGROUND: Identifying predictors of COVID-19 vaccination receipt in servicemembers (SM) is critical for protecting US military health. We report active-duty (AD) SM vaccination across 20 months of eligibility and assess factors associated with adoption of the primary series vaccine pre/post the Department of Defense (DoD) mandate, 8/24/21. …”
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    2387. Assessment of COVID-19 primary series vaccination and factors associated with early and late uptake among Servicemembers in the Military Health System
  19. 304499
    “…The physician group deemed the timely reminder of HH compliance as the second most critical improvement measure (Figure 3). Hand hygiene and optimal hand hygiene compliance rate. …”
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    1439. Identifying Barriers and Improving Measures for Hand Hygiene Practices Among Healthcare Workers in Korea: A Cross-Sectional Survey
  20. 304500
    “…BACKGROUND: Given increasing resistance and incidence of Candida infections in acute care hospitals, it is critical to understand the epidemiology of healthcare-associated acquisition of these fungal pathogens. …”
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    2460. Understanding acquisition of Candida glabrata in the healthcare setting
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